PMID- 27831922
OWN - NLM
STAT- MEDLINE
DCOM- 20170420
LR  - 20171116
IS  - 2191-0251 (Electronic)
IS  - 0334-018X (Linking)
VI  - 29
IP  - 12
DP  - 2016 Dec 1
TI  - The association between single nucleotide polymorphisms of the Apelin gene and 
      diabetes mellitus in a Chinese population.
PG  - 1397-1402
LID - 10.1515/jpem-2015-0441 [doi]
AB  - BACKGROUND: The objective of the study was to analyze the association of apelin 
      gene (APLN) single nucleotide polymorphisms (SNPs) and type 2 diabetes mellitus 
      (T2DM). METHODS: A total of 1966 subjects were enrolled in this study, including 
      168 cases (first batch), 330 cases (second batch), and 1468 nondiabetic controls. 
      The SNPs in the HapMap-HCB of APLN were detected using Sequenom MassARRAY SNP 
      technology and included rs2281068, rs3115757, rs2235309, and rs2235310. The 
      related clinical characteristics with glucose metabolism were tested, including 
      the fasting blood glucose (FPG), insulin (INS), C-peptide, glycosylated 
      hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-C), total 
      cholesterol (TC), triglycerides (TG), and high-density lipoprotein cholesterol 
      (HDL-C). RESULTS: A correlation between rs3115757 and rs2281068 and diabetes was 
      observed in first batch. Thus, we compared the SNPs (rs3115757 and rs2281068) 
      between the cases and controls after more cases were enrolled. In addition, the 
      results showed a significant correlation between APLN rs2281068 and diabetes 
      (p<0.05). However, age, BMI, WC, blood pressure, and serum markers in T2DM had no 
      relationship with APLN rs2281068. CONCLUSIONS: The SNP rs2281068 in APLN is 
      significantly related to diabetes mellitus in a Chinese population.
FAU - Zheng, Hui
AU  - Zheng H
FAU - Fan, Xiaofang
AU  - Fan X
FAU - Li, Xuesong
AU  - Li X
FAU - Zhang, Yu
AU  - Zhang Y
FAU - Fan, Yujuan
AU  - Fan Y
FAU - Zhang, Ning
AU  - Zhang N
FAU - Song, Yuping
AU  - Song Y
FAU - Ren, Fengdong
AU  - Ren F
FAU - Shen, Chunfang
AU  - Shen C
FAU - Shen, Jiayi
AU  - Shen J
FAU - Yang, Jialin
AU  - Yang J
AUID- ORCID: 0000-0002-9224-8278
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - J Pediatr Endocrinol Metab
JT  - Journal of pediatric endocrinology & metabolism : JPEM
JID - 9508900
RN  - 0 (APLN protein, human)
RN  - 0 (Apelin)
RN  - 0 (Biomarkers)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Apelin
MH  - Biomarkers/*analysis
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Genotype
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*genetics
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prognosis
EDAT- 2016/11/11 06:00
MHDA- 2017/04/21 06:00
CRDT- 2016/11/11 06:00
PHST- 2015/11/12 00:00 [received]
PHST- 2016/10/05 00:00 [accepted]
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2017/04/21 06:00 [medline]
PHST- 2016/11/11 06:00 [entrez]
AID - /j/jpem.ahead-of-print/jpem-2015-0441/jpem-2015-0441.xml [pii]
AID - 10.1515/jpem-2015-0441 [doi]
PST - ppublish
SO  - J Pediatr Endocrinol Metab. 2016 Dec 1;29(12):1397-1402. doi: 
      10.1515/jpem-2015-0441.