PMID- 27832642
OWN - NLM
STAT- MEDLINE
DCOM- 20170206
LR  - 20220321
IS  - 1421-9778 (Electronic)
IS  - 1015-8987 (Linking)
VI  - 39
IP  - 6
DP  - 2016
TI  - Cell-Derived Microparticles in Patients with Type 2 Diabetes Mellitus: a 
      Systematic Review and Meta-Analysis.
PG  - 2439-2450
AB  - BACKGROUND/AIMS: The aim of this study was to assess the association between 
      circulating cell-derived microparticles (MPs) and type 2 diabetes mellitus 
      (T2DM). METHODS: A literature search was performed systematically in PubMed and 
      Embase to identify available case-control or cross-sectional studies that 
      compared different types of cell-derived MPs in patients with T2DM and 
      non-diabetic controls. Pooled standardized mean differences (SMDs) of each MP 
      type were pooled using meta-analysis. RESULTS: Forty-eight studies involving 
      2,460 patients with T2DM and 1,880 non-diabetic controls were included for 
      systematic review and 34 of which were included for quantitative study by 
      meta-analysis. In the overall analysis, the levels of circulating total MPs 
      (TMPs), platelet-derived MPs (PMPs), monocyte-derived MPs (MMPs) and 
      endothelium-derived MPs (EMPs) were significantly higher in T2DM patients than 
      those in controls (TMPs: SMD, 0.64; 95%CI, 0.12 approximately 1.15; P=0.02; PMPs: SMD, 1.19; 
      95%CI, 0.88 approximately 1.50; P <0.00001; MMPs: SMD, 0.92; 95%CI, 0.66 approximately 1.17; P <0.00001; 
      EMPs: SMD, 0.73; 95%CI, 0.50 approximately 0.96; P <0.00001). Meanwhile, no significant 
      difference was shown in leukocyte-derived MPs (LMPs) level between diabetic and 
      non-diabetic groups (SMD, 0.37; 95%CI, -0.15 approximately 0.89; P=0.17). CONCLUSIONS: The 
      counts of TMPs, PMPs, MMPs and EMPs elevated in patients with T2DM. And 
      cell-derived MPs may play a role in the pathogenesis of T2DM.
CI  - (c) 2016 The Author(s) Published by S. Karger AG, Basel.
FAU - Li, Sheyu
AU  - Li S
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu, China.
FAU - Wei, Jia
AU  - Wei J
FAU - Zhang, Chenghui
AU  - Zhang C
FAU - Li, Xiaodan
AU  - Li X
FAU - Meng, Wentong
AU  - Meng W
FAU - Mo, Xianming
AU  - Mo X
FAU - Zhang, Qianying
AU  - Zhang Q
FAU - Liu, Qilin
AU  - Liu Q
FAU - Ren, Kaiyun
AU  - Ren K
FAU - Du, Rong
AU  - Du R
FAU - Tian, Haoming
AU  - Tian H
FAU - Li, Jianwei
AU  - Li J
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20161111
PL  - Germany
TA  - Cell Physiol Biochem
JT  - Cellular physiology and biochemistry : international journal of experimental 
      cellular physiology, biochemistry, and pharmacology
JID - 9113221
SB  - IM
MH  - Case-Control Studies
MH  - Cell-Derived Microparticles/*metabolism
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Humans
MH  - Publication Bias
MH  - Regression Analysis
EDAT- 2016/11/11 06:00
MHDA- 2017/02/07 06:00
CRDT- 2016/11/11 06:00
PHST- 2016/09/14 00:00 [accepted]
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2017/02/07 06:00 [medline]
PHST- 2016/11/11 06:00 [entrez]
AID - 000452512 [pii]
AID - 10.1159/000452512 [doi]
PST - ppublish
SO  - Cell Physiol Biochem. 2016;39(6):2439-2450. doi: 10.1159/000452512. Epub 2016 Nov 
      11.