PMID- 27832672
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20170313
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 49
IP  - 2
DP  - 2017 Feb
TI  - Tumor Necrosis Factor-alpha is Inversely Related to Free Thyroxine in Euthyroid 
      Subjects Without Diabetes.
PG  - 95-102
LID - 10.1055/s-0042-119211 [doi]
AB  - Lower thyroid functional status within the euthyroid range may confer increased 
      atherosclerosis susceptibility, as evidenced by increased intima media thickness 
      and coronary artery calcification. Associations of lower thyroid functional 
      status with pro-atherogenic (inflammatory) biomarkers may also extend into the 
      euthyroid range. Here we established relationships of plasma tumor necrosis 
      factor-alpha (TNF-alpha) with thyroid stimulating hormone (TSH) and free thyroxine (free 
      T(4)) in euthyroid subjects with and without Type 2 diabetes mellitus (T2DM). 
      Fasting TSH, free T(4), and TNF-alpha were measured in 81 nondiabetic subjects and in 
      73 T2DM subjects with Type 2 diabetes mellitus (T2DM; insulin using subjects were 
      excluded) with TSH and free T(4) levels each within the institutional reference 
      ranges. TSH was similar and free T(4) was slightly higher in T2DM (p<0.016). 
      Plasma TNF-alpha was increased in T2DM (p=0.007). In nondiabetic subjects, TNF-alpha was 
      correlated inversely with free T(4) (r=-0.25(4), p=0.022), whereas such a 
      relationship was absent in T2DM subjects (r=0.058, p=0.63). Multivariable linear 
      regression analysis showed that in nondiabetic subjects TNF-alpha remained inversely 
      associated with free T(4) after adjustment for age and sex (beta=-0.243, p=0.032) 
      and additionally for thyroid autoantibodies (beta=-0.251, p=0.027), contrasting the 
      lack of relationship in T2DM subjects (interaction: p=0.053). In T2DM subjects, 
      TNF-alpha was also unrelated to free T(4) taking account of possible confounders, as 
      well as after exclusion of subjects using metformin or antihypertensive 
      medication. In conclusion, higher levels of TNF-alpha relate to lower free T(4). 
      Low-normal thyroid function could influence pro-inflammatory pathways. This 
      relationship appears to be disturbed in T2DM.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - van Tienhoven-Wind, L J N
AU  - van Tienhoven-Wind LJ
AD  - Department of Endocrinology, University of Groningen and University Medical 
      Center Groningen, Groningen, The Netherlands.
FAU - Dullaart, R P F
AU  - Dullaart RP
AD  - Department of Endocrinology, University of Groningen and University Medical 
      Center Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20161110
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*blood/physiopathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Thyroid Function Tests
MH  - Thyroid Gland/*pathology/physiopathology
MH  - Thyroxine/*blood
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2016/11/11 06:00
MHDA- 2017/03/14 06:00
CRDT- 2016/11/11 06:00
PHST- 2016/11/11 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/11/11 06:00 [entrez]
AID - 10.1055/s-0042-119211 [doi]
PST - ppublish
SO  - Horm Metab Res. 2017 Feb;49(2):95-102. doi: 10.1055/s-0042-119211. Epub 2016 Nov 
      10.