PMID- 27833074
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 49
DP  - 2016 Dec 6
TI  - The prognostic value of long non coding RNAs in non small cell lung cancer: A 
      meta-analysis.
PG  - 81292-81304
LID - 10.18632/oncotarget.13223 [doi]
AB  - BACKGROUND: Reports have demonstrated the prognostic function of long non-coding 
      RNAS (lncRNAS) in patients with cancer. However, their prognostic functions in 
      non small cell lung cancer (NSCLC) remain controversial. We therefore performed a 
      meta-analysis on six lncRNAs (PVT1, AFAP1-AS1, LINC01133, ANRIL, MEG3 and UCA1) 
      to clarify their prognostic roles in NSCLC. RESULTS: Thirty-six studies involving 
      6267 patients with NSCLC and 34 lncRNAs were included. Of the listed lncRNAs, 20 
      were shown to negatively affect patients' overall survival while the high 
      expression of 13 lncRNAs indicated better survival outcomes. MATERIALS AND 
      METHODS: The log-rank p value and Kaplan-Meier survival curves of survival 
      outcomes were extracted for hazard ratio (HR) calculation. Survival outcomes were 
      measured by overall survival (OS) and event free survival (EFS) which were then 
      analyzed by calculating pooled hazard ratios. The heterogeneity was detected by Q 
      statistic and I-squared statistic. CONCLUSIONS: The abnormal expression of 
      lncRNAs may significantly affect NSCLC patients' survival and may serve as a 
      novel predictive factor for prognosis of NSCLC patients.
FAU - Wang, Manni
AU  - Wang M
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University, Chengdu, PR China.
FAU - Ma, Xuelei
AU  - Ma X
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University, Chengdu, PR China.
FAU - Zhu, Chenjing
AU  - Zhu C
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University, Chengdu, PR China.
FAU - Guo, Linghong
AU  - Guo L
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University, Chengdu, PR China.
FAU - Li, Qingfang
AU  - Li Q
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University, Chengdu, PR China.
FAU - Liu, Ming
AU  - Liu M
AD  - State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, 
      Sichuan University, Chengdu, PR China.
FAU - Zhang, Jing
AU  - Zhang J
AD  - West China Hospital, Sichuan University, Chengdu, PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/mortality/pathology/therapy
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*genetics/mortality/pathology/therapy
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Proportional Hazards Models
MH  - RNA, Long Noncoding/*genetics
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC5348393
OTO - NOTNLM
OT  - NSCLC
OT  - lncRNAs
OT  - meta-analysis
OT  - prognosis
COIS- CONFLICTS OF INTEREST None.
EDAT- 2016/11/12 06:00
MHDA- 2018/02/24 06:00
PMCR- 2016/12/06
CRDT- 2016/11/12 06:00
PHST- 2016/07/13 00:00 [received]
PHST- 2016/09/29 00:00 [accepted]
PHST- 2016/11/12 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
PHST- 2016/11/12 06:00 [entrez]
PHST- 2016/12/06 00:00 [pmc-release]
AID - 13223 [pii]
AID - 10.18632/oncotarget.13223 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Dec 6;7(49):81292-81304. doi: 10.18632/oncotarget.13223.