PMID- 27833598
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1664-302X (Print)
IS  - 1664-302X (Electronic)
IS  - 1664-302X (Linking)
VI  - 7
DP  - 2016
TI  - Alteration of Fecal Microbiota Profiles in Juvenile Idiopathic Arthritis. 
      Associations with HLA-B27 Allele and Disease Status.
PG  - 1703
LID - 1703
AB  - Alteration of gut microbiota is involved in several chronic inflammatory and 
      autoimmune diseases, including rheumatoid arthritis, and gut microbial 
      "pro-arthritogenic" profiles have been hypothesized. Intestinal inflammation may 
      be involved in spondyloarthropathies and in a subset of patients affected by 
      Juvenile Idiopathic Arthritis (JIA), the most common chronic rheumatic disease of 
      childhood. We compared the fecal microbiota composition of JIA patients with 
      healthy subjects (HS), evaluating differences in microbial profiles between 
      sub-categories of JIA, such as enthesitis-related arthritis (JIA-ERA), in which 
      inflammation of entheses occurs, and polyarticular JIA, non-enthesitis related 
      arthritis (JIA-nERA). Through taxon-level analysis, we discovered alteration of 
      fecal microbiota components that could be involved in subclinical gut 
      inflammation, and promotion of joint inflammation. We observed abundance in 
      Ruminococcaceae in both JIA categories, reduction in Clostridiaceae and 
      Peptostreptococcaceae in JIA-ERA, and increase in Veillonellaceae in JIA-nERA, 
      respectively, compared with HS. Among the more relevant genera, we found an 
      increase in Clostridium cluster XIVb, involved in colitis and arthritis, in 
      JIA-ERA patients compared with HS, and a trend of decrease in Faecalibacterium, 
      known for anti-inflammatory properties, in JIA-nERA compared with JIA-ERA and HS. 
      Differential abundant taxa identified JIA patients for the HLA-B27 allele, 
      including Bilophila, Clostridium cluster XIVb, Oscillibacter, and Parvimonas. 
      Prediction analysis of metabolic functions showed that JIA-ERA metagenome was 
      differentially enriched in bacterial functions related to cell motility and 
      chemotaxis, suggesting selection of potential virulence traits. We also 
      discovered differential microbial profiles and intra-group variability among 
      active disease and remission, suggesting instability of microbial ecosystem in 
      autoimmune diseases with respect to healthy status. Similarly to other chronic 
      autoimmune and inflammatory diseases, different microbial profiles, as observed 
      among different JIA subgroups compared to HS, and potential functional 
      acquisition related to migration, could promote inflammation and contribute to 
      the disease pathogenesis.
FAU - Di Paola, Monica
AU  - Di Paola M
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer 
      Children's Hospital, University of Florence Florence, Italy.
FAU - Cavalieri, Duccio
AU  - Cavalieri D
AD  - Department of Biology, University of Florence Florence, Italy.
FAU - Albanese, Davide
AU  - Albanese D
AD  - Fondazione E. Mach, Research and Innovation Center Trento, Italy.
FAU - Sordo, Maddalena
AU  - Sordo M
AD  - Fondazione E. Mach, Research and Innovation Center Trento, Italy.
FAU - Pindo, Massimo
AU  - Pindo M
AD  - Fondazione E. Mach, Research and Innovation Center Trento, Italy.
FAU - Donati, Claudio
AU  - Donati C
AD  - Fondazione E. Mach, Research and Innovation Center Trento, Italy.
FAU - Pagnini, Ilaria
AU  - Pagnini I
AD  - Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence 
      Florence, Italy.
FAU - Giani, Teresa
AU  - Giani T
AD  - Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence 
      Florence, Italy.
FAU - Simonini, Gabriele
AU  - Simonini G
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer 
      Children's Hospital, University of FlorenceFlorence, Italy; Rheumatology Unit, 
      Anna Meyer Children's Hospital, University of FlorenceFlorence, Italy.
FAU - Paladini, Alessia
AU  - Paladini A
AD  - Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence 
      Florence, Italy.
FAU - Lionetti, Paolo
AU  - Lionetti P
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer 
      Children's Hospital, University of Florence Florence, Italy.
FAU - De Filippo, Carlotta
AU  - De Filippo C
AD  - Institute of Biometeorology, National Research Council Florence, Italy.
FAU - Cimaz, Rolando
AU  - Cimaz R
AD  - Department of Neuroscience, Psychology, Drug Research and Child Health, Meyer 
      Children's Hospital, University of FlorenceFlorence, Italy; Rheumatology Unit, 
      Anna Meyer Children's Hospital, University of FlorenceFlorence, Italy.
LA  - eng
PT  - Journal Article
DEP - 20161026
PL  - Switzerland
TA  - Front Microbiol
JT  - Frontiers in microbiology
JID - 101548977
PMC - PMC5080347
OTO - NOTNLM
OT  - HLA-B27 allele
OT  - enthesitis-related arthritis
OT  - gut microbiota
OT  - juvenile idiopathic arthritis
OT  - metagenomics
EDAT- 2016/11/12 06:00
MHDA- 2016/11/12 06:01
PMCR- 2016/10/26
CRDT- 2016/11/12 06:00
PHST- 2016/07/15 00:00 [received]
PHST- 2016/10/12 00:00 [accepted]
PHST- 2016/11/12 06:00 [entrez]
PHST- 2016/11/12 06:00 [pubmed]
PHST- 2016/11/12 06:01 [medline]
PHST- 2016/10/26 00:00 [pmc-release]
AID - 10.3389/fmicb.2016.01703 [doi]
PST - epublish
SO  - Front Microbiol. 2016 Oct 26;7:1703. doi: 10.3389/fmicb.2016.01703. eCollection 
      2016.