PMID- 27833702
OWN - NLM
STAT- MEDLINE
DCOM- 20170313
LR  - 20221207
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2016
DP  - 2016
TI  - Serum Lipoprotein (a) Levels in Black South African Type 2 Diabetes Mellitus 
      Patients.
PG  - 5743838
LID - 5743838
AB  - Lipoprotein (a) (Lp(a)) which is a low-density lipoprotein-like particle 
      containing apo(a) is considered as an emergent cardiovascular risk factor. Type 2 
      diabetes mellitus (T2DM) is associated with a two- to threefold increase in the 
      risk of cardiovascular disease (CVD). The aim of this study was to investigate 
      the levels of Lp(a) in Black South African T2DM patients and its association with 
      other metabolic factors. 67 T2DM patients and 48 healthy control participants 
      were recruited for the cross-sectional study. The Lp(a) level was determined by 
      ELISA and the result was analyzed using SPSS. The Lp(a) level in diabetics was 
      found to be significantly increased (P = 0.001) when compared to the normal 
      healthy group. In the diabetic group, the Lp(a) levels correlated significantly 
      with the duration of diabetes (P = 0.008) and oxidized LDL (ox-LDL) levels (P = 
      0.03) and decreased total antioxidant capacity (P = 0.001). The third tertile of 
      Lp(a) was significantly correlated with increased ox-LDL, C-reactive protein, and 
      triglycerides and decreased total antioxidant capacity.
FAU - Joseph, Jim
AU  - Joseph J
AUID- ORCID: 0000-0001-7404-4178
AD  - Division of Medical Biochemistry, Department of Human Biology, Faculty of Health 
      Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 
      5100, South Africa.
FAU - Ganjifrockwala, Farzana
AU  - Ganjifrockwala F
AUID- ORCID: 0000-0003-2647-8056
AD  - Division of Medical Biochemistry, Department of Human Biology, Faculty of Health 
      Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 
      5100, South Africa.
FAU - George, Grace
AU  - George G
AUID- ORCID: 0000-0002-4662-720X
AD  - Division of Medical Biochemistry, Department of Human Biology, Faculty of Health 
      Sciences, Walter Sisulu University, Mthatha Campus, Nelson Mandela Drive, Mthatha 
      5100, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20161019
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
RN  - 0 (Antioxidants)
RN  - 0 (Lipoprotein(a))
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Triglycerides)
RN  - 0 (oxidized low density lipoprotein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Antioxidants/metabolism
MH  - *Black People
MH  - C-Reactive Protein/metabolism
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Lipoprotein(a)/*blood
MH  - Lipoproteins, LDL/blood
MH  - Male
MH  - Middle Aged
MH  - South Africa
MH  - Triglycerides/blood
PMC - PMC5090092
EDAT- 2016/11/12 06:00
MHDA- 2017/03/14 06:00
PMCR- 2016/10/19
CRDT- 2016/11/12 06:00
PHST- 2016/06/29 00:00 [received]
PHST- 2016/09/08 00:00 [revised]
PHST- 2016/09/25 00:00 [accepted]
PHST- 2016/11/12 06:00 [entrez]
PHST- 2016/11/12 06:00 [pubmed]
PHST- 2017/03/14 06:00 [medline]
PHST- 2016/10/19 00:00 [pmc-release]
AID - 10.1155/2016/5743838 [doi]
PST - ppublish
SO  - Oxid Med Cell Longev. 2016;2016:5743838. doi: 10.1155/2016/5743838. Epub 2016 Oct 
      19.