PMID- 27837101
OWN - NLM
STAT- MEDLINE
DCOM- 20170606
LR  - 20210109
IS  - 1468-330X (Electronic)
IS  - 0022-3050 (Linking)
VI  - 88
IP  - 3
DP  - 2017 Mar
TI  - Phase II randomised controlled trial of a 6-month self-managed community exercise 
      programme for people with Parkinson's disease.
PG  - 204-211
LID - 10.1136/jnnp-2016-314508 [doi]
AB  - BACKGROUND: Evidence for longer term exercise delivery for people with 
      Parkinson's disease (PwP) is deficient. AIM: Evaluate safety and adherence to a 
      minimally supported community exercise intervention and estimate effect sizes 
      (ES). METHODS: 2-arm parallel phase II randomised controlled trial with blind 
      assessment. PwP able to walk >/=100 m and with no contraindication to exercise were 
      recruited from the Thames valley, UK, and randomised (1:1) to intervention 
      (exercise) or control (handwriting) groups, via a concealed computer-generated 
      list. Groups received a 6-month, twice weekly programme. Exercise was undertaken 
      in community facilities (30 min aerobic and 30 min resistance) and handwriting at 
      home, both were delivered through workbooks with monthly support visits. Primary 
      outcome was a 2 min walk, with motor symptoms (Movement Disorder Society Unified 
      Parkinson's Disease Rating Scale, MDS-UPDRS III), fitness, health and well-being 
      measured. RESULTS: Between December 2011 and August 2013, n=53 (n=54 analysed) 
      were allocated to exercise and n=52 (n=51 analysed) to handwriting. N=37 adhered 
      to the exercise, most attending >/=1 session/week. Aerobic exercise was performed 
      in 99% of attended sessions and resistance in 95%. Attrition and adverse events 
      (AEs) were similar between groups, no serious AEs (n=2 exercise, n=3 handwriting) 
      were related, exercise group-related AEs (n=2) did not discontinue intervention. 
      Largest effects were for motor symptoms (2 min walk ES=0.20 (95% CI -0.44 to 
      0.45) and MDS-UPDRS III ES=-0.30 (95% CI 0.07 to 0.54)) in favour of exercise 
      over the 12-month follow-up period. Some small effects were observed in fitness 
      and well-being measures (ES>0.1). CONCLUSIONS: PwP exercised safely and the 
      possible long-term benefits observed support a substantive evaluation of this 
      community programme. TRIAL REGISTRATION NUMBER: NCT01439022.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Collett, Johnny
AU  - Collett J
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
FAU - Franssen, Marloes
AU  - Franssen M
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
AD  - Nuffield Department of Primary Care Health Sciences, University of Oxford, 
      Oxford, UK.
FAU - Meaney, Andy
AU  - Meaney A
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
FAU - Wade, Derick
AU  - Wade D
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
AD  - Oxford Centre for Enablement, Oxford University Hospitals, Oxford, UK.
FAU - Izadi, Hooshang
AU  - Izadi H
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
AD  - Department of Mechanical Engineering and Mathematical Sciences, Oxford Brookes 
      University, Oxford, UK.
FAU - Tims, Martin
AU  - Tims M
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
FAU - Winward, Charlotte
AU  - Winward C
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
AD  - Department of Infectious Disease, Churchill Hospital, Oxford University 
      Hospitals, Oxford, UK.
FAU - Bogdanovic, Marko
AU  - Bogdanovic M
AD  - Department of Neurology, Royal Berkshire Hospital, Reading, UK.
FAU - Farmer, Andrew
AU  - Farmer A
AD  - Nuffield Department of Primary Care Health Sciences, University of Oxford, 
      Oxford, UK.
FAU - Dawes, Helen
AU  - Dawes H
AD  - Movement Science Group, OxINAHR, Oxford Brookes University, Oxford, UK.
AD  - Department of Clinical Neurology, University of Oxford, Oxford, UK.
LA  - eng
SI  - ClinicalTrials.gov/NCT01439022
GR  - PB-PG-0110-20250/DH_/Department of Health/United Kingdom
PT  - Clinical Trial, Phase II
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161111
PL  - England
TA  - J Neurol Neurosurg Psychiatry
JT  - Journal of neurology, neurosurgery, and psychiatry
JID - 2985191R
SB  - IM
MH  - Aged
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Muscle Strength/physiology
MH  - Parkinson Disease/*therapy
MH  - Quality of Life
MH  - Self Care/*methods
MH  - United Kingdom
EDAT- 2016/11/12 06:00
MHDA- 2017/06/07 06:00
CRDT- 2016/11/13 06:00
PHST- 2016/07/22 00:00 [received]
PHST- 2016/09/26 00:00 [revised]
PHST- 2016/10/21 00:00 [accepted]
PHST- 2016/11/12 06:00 [pubmed]
PHST- 2017/06/07 06:00 [medline]
PHST- 2016/11/13 06:00 [entrez]
AID - jnnp-2016-314508 [pii]
AID - 10.1136/jnnp-2016-314508 [doi]
PST - ppublish
SO  - J Neurol Neurosurg Psychiatry. 2017 Mar;88(3):204-211. doi: 
      10.1136/jnnp-2016-314508. Epub 2016 Nov 11.