PMID- 27837279
OWN - NLM
STAT- MEDLINE
DCOM- 20170809
LR  - 20181113
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 255
IP  - 3
DP  - 2017 Mar
TI  - Optic disc and peripapillary retinal nerve fiber layer characteristics associated 
      with glaucomatous optic disc in young myopia.
PG  - 591-598
LID - 10.1007/s00417-016-3542-4 [doi]
AB  - PURPOSE: To explore optic disc and peripapillary retinal nerve fiber layer (RNFL) 
      features associated with glaucomatous optic disc (GOD) in young myopia. METHODS: 
      Presence of GOD, optic disc tilt, and disc torsion were determined using fundus 
      photographs. If the measured disc tilt ratio was >1.3, the optic disc was 
      classified as tilted. Optic disc torsion was defined as a >15 degrees  deviation in the 
      long axis of the optic disc from the vertical meridian. The average and four 
      quadrants RNFL thicknesses were assessed using spectral domain optical coherence 
      tomography (SD-OCT). Logistic regression analyses were performed to identify 
      factors associated with the presence of GOD. RESULTS: Nine hundred and sixty 
      myopic subjects were recruited from four refractive surgery clinic databases. The 
      mean age was 26.6 +/- 5.7 years and spherical equivalent (SE) was -5.5 +/- 2.5 
      diopters. Among 960 eyes, 26 (2.7%) received GOD group classification. Among 934 
      normal eyes, 290 (31.0%) had titled optic discs. Eighteen eyes (69.2%) in the GOD 
      group had tilted optic discs. When compared to normal eyes, the GOD group had 
      significantly higher tilt ratios (1.4 +/- 0.2 vs. 1.2 +/- 0.1, p < 0.001) and less SE 
      (-7.8 +/- 2.7 vs. -5.4 +/- 2.5 diopters, p < 0.001). Greater tilt ratio (odds ratio 
      (OR) = 4.9, p < 0.001), less SE (OR = 0.708, p < 0.001), and thinner average RNFL 
      (OR = 0.910, p = 0.001) were significantly associated with GOD. Among 934 normal 
      eyes, 366 (39.2%) displayed disc torsion, while among 26 glaucomatous eyes, eight 
      (30.8%) displayed disc torsion. CONCLUSIONS: Optic disc tilt was found in 
      approximately one-third of young myopic eyes and was independently associated 
      with the presence of GOD.
FAU - Lee, Jong Eun
AU  - Lee JE
AD  - Department of Ophthalmology, College of Medicine, Asan Medical Center, University 
      of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea.
FAU - Sung, Kyung Rim
AU  - Sung KR
AD  - Department of Ophthalmology, College of Medicine, Asan Medical Center, University 
      of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea. 
      sungeye@gmail.com.
FAU - Park, Ji Min
AU  - Park JM
AD  - Department of Ophthalmology, College of Medicine, Asan Medical Center, University 
      of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea.
FAU - Yoon, Joo Young
AU  - Yoon JY
AD  - Department of Ophthalmology, College of Medicine, Asan Medical Center, University 
      of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea.
FAU - Kang, Sung Yong
AU  - Kang SY
AD  - Eyereum Eye Clinic, Seoul, Korea.
FAU - Park, Sung Bae
AU  - Park SB
AD  - SU Yonsei Eye Clinic, Seoul, Korea.
FAU - Koo, Hyung Jin
AU  - Koo HJ
AD  - Nunemiso Eye Clinic, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20161111
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adult
MH  - Female
MH  - Glaucoma/complications/*diagnosis/physiopathology
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Myopia/complications/*diagnosis/physiopathology
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis/etiology/physiopathology
MH  - Photography
MH  - Refraction, Ocular
MH  - Retinal Ganglion Cells/*pathology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Visual Field Tests
MH  - Visual Fields
OTO - NOTNLM
OT  - Glaucoma
OT  - Myopia
OT  - Optic disc tilt
OT  - Optical coherence tomography
OT  - Retinal nerve fiber layer
EDAT- 2016/11/12 06:00
MHDA- 2017/08/10 06:00
CRDT- 2016/11/13 06:00
PHST- 2016/04/15 00:00 [received]
PHST- 2016/10/31 00:00 [accepted]
PHST- 2016/10/19 00:00 [revised]
PHST- 2016/11/12 06:00 [pubmed]
PHST- 2017/08/10 06:00 [medline]
PHST- 2016/11/13 06:00 [entrez]
AID - 10.1007/s00417-016-3542-4 [pii]
AID - 10.1007/s00417-016-3542-4 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2017 Mar;255(3):591-598. doi: 
      10.1007/s00417-016-3542-4. Epub 2016 Nov 11.