PMID- 27837558
OWN - NLM
STAT- MEDLINE
DCOM- 20170912
LR  - 20170912
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 951
DP  - 2016
TI  - Menstrual Blood-Derived Stem Cells: In Vitro and In Vivo Characterization of 
      Functional Effects.
PG  - 111-121
AB  - Accumulating evidence has demonstrated that menstrual blood stands as a viable 
      source of stem cells. Menstrual blood-derived stem cells (MenSCs) are 
      morphologically and functionally similar to cells directly extracted from the 
      endometrium, and present dual expression of mesenchymal and embryonic cell 
      markers, thus becoming interesting tools for regenerative medicine. Functional 
      reports show higher proliferative and self-renewal capacities than bone 
      marrow-derived stem cells, as well as successful differentiation into 
      hepatocyte-like cells, glial-like cells, endometrial stroma-like cells, among 
      others. Moreover, menstrual blood stem cells may be used with increased 
      efficiency in reprogramming techniques for induced Pluripotent Stem cell (iPS) 
      generation. Experimental studies have shown successful treatment of stroke, 
      colitis, limb ischemia, coronary disease, Duchenne's muscular atrophy and 
      streptozotocin-induced type 1 diabetes animal models with MenSCs. As we envision 
      an off-the-shelf product for cell therapy, cryopreserved MenSCs appear as a 
      feasible clinical product. Clinical applications, although still very limited, 
      have great potential and ongoing studies should be disclosed in the near future.
FAU - Rodrigues, Maria Carolina Oliveira
AU  - Rodrigues MC
AD  - Division of Clinical Immunology, Ribeirao Preto Medical School, University of Sao 
      Paulo, Ribeirao Preto, Brazil. mcarolor@usp.br.
FAU - Lippert, Trenton
AU  - Lippert T
AD  - Department of Neurosurgery and Brain Repair, Morsani College of Medicine, 
      University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.
FAU - Nguyen, Hung
AU  - Nguyen H
AD  - Department of Neurosurgery and Brain Repair, Morsani College of Medicine, 
      University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.
FAU - Kaelber, Sussannah
AU  - Kaelber S
AD  - Department of Neurosurgery and Brain Repair, Morsani College of Medicine, 
      University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.
FAU - Sanberg, Paul R
AU  - Sanberg PR
AD  - Department of Neurosurgery and Brain Repair, Morsani College of Medicine, 
      University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA.
FAU - Borlongan, Cesar V
AU  - Borlongan CV
AD  - Department of Neurosurgery and Brain Repair, Morsani College of Medicine, 
      University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA. 
      cborlong@health.usf.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Proliferation
MH  - Cell Separation/methods
MH  - Clinical Trials as Topic
MH  - Colitis/pathology/*therapy
MH  - Cryopreservation/ethics/*methods
MH  - Diabetes Mellitus, Experimental/pathology/therapy
MH  - Disease Models, Animal
MH  - Endometrium/*cytology/physiology
MH  - Female
MH  - Humans
MH  - Induced Pluripotent Stem Cells/*cytology/physiology
MH  - Menstruation/physiology
MH  - Mice
MH  - Muscular Dystrophy, Duchenne/pathology/*therapy
MH  - Stroke/pathology/*therapy
OTO - NOTNLM
OT  - Endometrial stem cells
OT  - Endometrium
OT  - Immunomodulation
OT  - Menstrual blood stem cells
OT  - Pluripotent stem cells
OT  - Regenerative medicine
OT  - Stem cell therapy
EDAT- 2016/11/12 06:00
MHDA- 2017/09/13 06:00
CRDT- 2016/11/13 06:00
PHST- 2016/11/13 06:00 [entrez]
PHST- 2016/11/12 06:00 [pubmed]
PHST- 2017/09/13 06:00 [medline]
AID - 10.1007/978-3-319-45457-3_9 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2016;951:111-121. doi: 10.1007/978-3-319-45457-3_9.