PMID- 27838632
OWN - NLM
STAT- MEDLINE
DCOM- 20170620
LR  - 20181202
IS  - 1758-1133 (Electronic)
IS  - 0049-4755 (Linking)
VI  - 47
IP  - 2
DP  - 2017 Apr
TI  - Paradoxical reactions in children with tuberculosis.
PG  - 109-113
LID - 10.1177/0049475516676388 [doi]
AB  - We sought to determine the incidence and clinical spectrum of the paradoxical 
      reaction (PR) to treatment in 1000 children with tuberculosis (TB). Its incidence 
      was 3.3%, presenting as mediastinal adenopathy (n = 12), central nervous system 
      (CNS) tuberculoma (n = 8), increasing size of lymph nodes (n = 8) and serositis 
      (n = 5). Symptoms included breathlessness (n = 7, 21.2%), neck swellings (n = 5, 
      15.2%), hemiplegia (n = 3, 9.1%), raised intracranial tension (n = 2, 6.1%) and 
      fever or diabetes insipidus (n = 1, 3% each). The mean age of onset of PR was 3.5 
      months after the start of anti-TB medication. PR was seen predominantly in boys. 
      Mediastinal lymphadenopathy was more common in children aged <2 years. 
      Tuberculomas were more common in children aged 2-5 years. Nodal enlargement and 
      serositis were seen equally in all age groups.
FAU - Shah, Ira
AU  - Shah I
AD  - Paediatric TB Clinic, BJ Wadia Hospital for Children, Mumbai, India.
FAU - Bhaskar, M V
AU  - Bhaskar MV
AD  - Paediatric TB Clinic, BJ Wadia Hospital for Children, Mumbai, India.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20161112
PL  - England
TA  - Trop Doct
JT  - Tropical doctor
JID - 1301706
RN  - 0 (Antitubercular Agents)
SB  - IM
MH  - Adolescent
MH  - Antitubercular Agents/adverse effects/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Fever/drug therapy
MH  - Humans
MH  - Incidence
MH  - Lymph Nodes/*pathology
MH  - Male
MH  - Pericardial Effusion/etiology/pathology
MH  - Pleural Effusion/etiology/pathology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tuberculoma/pathology
MH  - Tuberculosis/*drug therapy/pathology
OTO - NOTNLM
OT  - Tuberculosis
OT  - children
OT  - diabetes insipidus
OT  - paradoxical reaction
OT  - serositis
OT  - tuberculoma
EDAT- 2016/11/14 06:00
MHDA- 2017/06/21 06:00
CRDT- 2016/11/14 06:00
PHST- 2016/11/14 06:00 [pubmed]
PHST- 2017/06/21 06:00 [medline]
PHST- 2016/11/14 06:00 [entrez]
AID - 0049475516676388 [pii]
AID - 10.1177/0049475516676388 [doi]
PST - ppublish
SO  - Trop Doct. 2017 Apr;47(2):109-113. doi: 10.1177/0049475516676388. Epub 2016 Nov 
      12.