PMID- 27839822
OWN - NLM
STAT- MEDLINE
DCOM- 20171106
LR  - 20220408
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 227
DP  - 2017 Jan 15
TI  - HMGA1 is a novel candidate gene for myocardial infarction susceptibility.
PG  - 331-334
LID - S0167-5273(16)33544-6 [pii]
LID - 10.1016/j.ijcard.2016.11.088 [doi]
AB  - BACKGROUND: Acute Myocardial infarction (AMI), a leading cause of morbidity and 
      mortality worldwide, is a dreadful acute complication of coronary 
      atherosclerosis. Type 2 diabetes mellitus (T2DM) is associated with an increased 
      risk of developing AMI. The architectural transcription factor 
      high-mobility-group AT-hook 1 (HMGA1) has been involved in atherosclerosis, 
      plaque formation, inflammation, and in the pathogenesis of insulin resistance and 
      T2DM. An association of the HMGA1 rs146052672 variant with T2DM has been recently 
      reported. Thus, our aim was to evaluate whether this variant was also associated 
      with AMI. METHODS AND RESULTS: In a case-control study from Calabria (Southern 
      Italy), we enrolled 254 consecutive, unrelated, patients with first diagnosis of 
      AMI, and 508 age, sex-matched controls. Genotyping of the rs146052672 was 
      performed using the TaqMan allelic discrimination method. We found that this 
      variant was present in 7.9% of AMI patients and in 3.1% of controls (p=0.003). 
      Multiple logistic regression confirmed that the rs146052672 was significantly 
      associated with AMI (OR=2.54; p=0.002), and this association was independent of 
      classical cardiovascular risk factors such as gender, hypertension, obesity and 
      T2DM (for all, p<0.05). CONCLUSIONS: Our findings demonstrate that a relationship 
      exists between the HMGA1 rs146052672 variant and AMI, suggesting that defects at 
      the HMGA1 locus may play a pathogenetic role in AMI, in the absence of T2DM and 
      other cardiovascular risk factors.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - De Rosa, Salvatore
AU  - De Rosa S
AD  - Division of Cardiology, Department of Medical and Surgical Sciences, "Magna 
      Graecia" University, Catanzaro, Italy.
FAU - Chiefari, Eusebio
AU  - Chiefari E
AD  - Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Salerno, Nadia
AU  - Salerno N
AD  - Division of Cardiology, Department of Medical and Surgical Sciences, "Magna 
      Graecia" University, Catanzaro, Italy.
FAU - Ventura, Valeria
AU  - Ventura V
AD  - Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - D'Ascoli, Greta Luana
AU  - D'Ascoli GL
AD  - Division of Cardiology, Department of Medical and Surgical Sciences, "Magna 
      Graecia" University, Catanzaro, Italy.
FAU - Arcidiacono, Biagio
AU  - Arcidiacono B
AD  - Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Ambrosio, Giuseppe
AU  - Ambrosio G
AD  - Division of Cardiology, Department of Medical and Surgical Sciences, "Magna 
      Graecia" University, Catanzaro, Italy.
FAU - Bilotta, Francesco Luciano
AU  - Bilotta FL
AD  - Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Torella, Daniele
AU  - Torella D
AD  - Division of Cardiology, Department of Medical and Surgical Sciences, "Magna 
      Graecia" University, Catanzaro, Italy.
FAU - Foti, Daniela
AU  - Foti D
AD  - Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 
      Catanzaro, Italy.
FAU - Indolfi, Ciro
AU  - Indolfi C
AD  - Division of Cardiology, Department of Medical and Surgical Sciences, "Magna 
      Graecia" University, Catanzaro, Italy; URT-CNR, Department of Medicine, Consiglio 
      Nazionale delle Ricerche of IFC, Catanzaro, Italy. Electronic address: 
      indolfi@unicz.it.
FAU - Brunetti, Antonio
AU  - Brunetti A
AD  - Department of Health Sciences, University "Magna Graecia" of Catanzaro, 88100 
      Catanzaro, Italy. Electronic address: brunetti@unicz.it.
LA  - eng
PT  - Journal Article
DEP - 20161109
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 124544-67-8 (HMGA1a Protein)
SB  - IM
CIN - Int J Cardiol. 2018 Apr 1;256:37. PMID: 29454416
CIN - Int J Cardiol. 2018 Apr 1;256:38. PMID: 29454417
MH  - Aged
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genotype
MH  - HMGA1a Protein/*genetics
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*genetics
MH  - Polymorphism, Genetic/genetics
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Diabetes
OT  - Polymorphism
OT  - Risk factors
EDAT- 2016/11/15 06:00
MHDA- 2017/11/07 06:00
CRDT- 2016/11/15 06:00
PHST- 2016/08/02 00:00 [received]
PHST- 2016/11/06 00:00 [accepted]
PHST- 2016/11/15 06:00 [pubmed]
PHST- 2017/11/07 06:00 [medline]
PHST- 2016/11/15 06:00 [entrez]
AID - S0167-5273(16)33544-6 [pii]
AID - 10.1016/j.ijcard.2016.11.088 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Jan 15;227:331-334. doi: 10.1016/j.ijcard.2016.11.088. Epub 
      2016 Nov 9.