PMID- 2784072
OWN - NLM
STAT- MEDLINE
DCOM- 19890418
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 63
IP  - 7
DP  - 1989 Apr 1
TI  - Immunogenetic and immunologic studies of differentiated thyroid cancer.
PG  - 1318-26
AB  - The authors have studied in detail human leukocyte antigen (HLA) association in 
      87 Hungarian patients with thyroid epithelial carcinoma. The authors also 
      examined in a small group of patients, five parameters of cell-mediated immunity 
      and related them to HLA as well as to lymphocytic infiltration of the 
      tumor/normal tissue interface. HLA-DR1 was significantly associated with thyroid 
      carcinoma; the strongest association was in patients with follicular histologic 
      features and DR1 homozygotes were not at greater risk for thyroid cancer. The 
      HLA-DR3 was nonsignificantly increased in patients with papillary or mixed 
      histologic features. The HLA-DR1, 3 heterozygotes were highly associated with 
      follicular carcinoma, carried no risk for papillary carcinoma, and an 
      intermediate risk for tumors with mixed histologic features. Because of the small 
      proportion of DR1, 3 heterozygotes in the follicular and mixed histologic group, 
      its predictive value at the population level was low. Better predictive potential 
      was shown for the phenotype DR1 and/or DR3. Neither metastatic disease nor age at 
      diagnosis (less than 45 years) could be related to HLA phenotypes. Patients in 
      all histologic variants showed some measure of cell-mediated immunity compared to 
      controls. Patients with papillary carcinoma showed an overall better response 
      than those with tumors with follicular or mixed histology. The HLA-DR could not 
      be related to cell-mediated immune response. Patients with papillary carcinoma 
      with a good cell-mediated immune response occurred with much lower infiltration 
      of the tumor boundary with lymphocyte whereas the follicular carcinoma less 
      cell-mediated immunity was associated with dense lymphocytic infiltration, 
      suggesting the biological relevance of lymphocytic infiltration may be different 
      for the two histologic variants.
FAU - Juhasz, F
AU  - Juhasz F
AD  - Department of Surgery, Medical University, Debrecen, Hungary.
FAU - Boros, P
AU  - Boros P
FAU - Szegedi, G
AU  - Szegedi G
FAU - Balazs, G
AU  - Balazs G
FAU - Suranyi, P
AU  - Suranyi P
FAU - Kraszits, E
AU  - Kraszits E
FAU - Stenszky, V
AU  - Stenszky V
FAU - Farid, N R
AU  - Farid NR
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adenocarcinoma/immunology
MH  - Adult
MH  - Alleles
MH  - Antigens, Neoplasm/analysis
MH  - Carcinoma/genetics/*immunology
MH  - Carcinoma, Papillary/immunology
MH  - Disease Susceptibility
MH  - Female
MH  - HLA Antigens/*analysis/genetics
MH  - Humans
MH  - Immunity, Cellular
MH  - Male
MH  - Middle Aged
MH  - T-Lymphocytes/immunology
MH  - Thyroid Neoplasms/genetics/*immunology
EDAT- 1989/04/01 00:00
MHDA- 1989/04/01 00:01
CRDT- 1989/04/01 00:00
PHST- 1989/04/01 00:00 [pubmed]
PHST- 1989/04/01 00:01 [medline]
PHST- 1989/04/01 00:00 [entrez]
AID - 10.1002/1097-0142(19890401)63:7<1318::aid-cncr2820630716>3.0.co;2-r [doi]
PST - ppublish
SO  - Cancer. 1989 Apr 1;63(7):1318-26. doi: 
      10.1002/1097-0142(19890401)63:7<1318::aid-cncr2820630716>3.0.co;2-r.