PMID- 27840827
OWN - NLM
STAT- MEDLINE
DCOM- 20170210
LR  - 20181113
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2016
DP  - 2016
TI  - Prevalence and Prognosis of Anemia in Dogs with Degenerative Mitral Valve 
      Disease.
PG  - 4727054
LID - 4727054
AB  - In humans, heart failure (HF) and renal insufficiency (RI) have negative 
      reciprocal effects, and anemia can exacerbate their progression. In this 
      retrospective study, the prevalence and prognostic significance of anemia in 114 
      dogs with degenerative mitral valve disease (DMVD) was investigated. Pretreatment 
      clinical parameters, prevalence of anemia and azotemia, and survival time were 
      analyzed in relation to HF severity. The prevalence of anemia was highest in dogs 
      with the modified New York Heart Association (NYHA) class IV HF (33.3%), followed 
      by classes III (15.2%) and II (0%; p < 0.001). The presence of anemia was 
      associated with HF severity and blood creatinine > 1.6 mg/dL (both p < 0.001). 
      Anemic dogs had a shorter median survival [13 months; 95% confidence interval 
      (CI): 0.7-19.1] than nonanemic dogs (28 months; 95% CI: 15.3-40.7; p < .001). 
      NYHA class IV (hazard ratio (HR): 3.1, 95% CI: 2.2-4.3; p < 0.001), left 
      atrium/aorta ratio > 1.7 (HR: 2.7, 95% CI: 1.7-4.2; p = 0.001), and presence of 
      anemia (HR: 1.43, 95% CI: 1.1-1.9; p = 0.004) emerged as predictors of mortality. 
      A cardiorenal-anemia syndrome-like triangle was observed and anemia was a 
      prognostic factor for survival in dogs with DMVD.
FAU - Yu, Ivarosa Bing-Ye
AU  - Yu IB
AD  - Institute of Veterinary Clinical Science, Veterinary School, National Taiwan 
      University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan.
FAU - Huang, Hui-Pi
AU  - Huang HP
AUID- ORCID: 0000-0001-5497-0158
AD  - Institute of Veterinary Clinical Science, Veterinary School, National Taiwan 
      University, No. 1, Section 4, Roosevelt Road, Taipei 100, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20161020
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
SB  - IM
MH  - *Anemia/blood/epidemiology/etiology/veterinary
MH  - Animals
MH  - *Dog Diseases/blood/epidemiology
MH  - Dogs
MH  - Female
MH  - *Heart Valve Diseases/blood/complications/epidemiology/veterinary
MH  - Humans
MH  - Male
MH  - Prevalence
PMC - PMC5093253
EDAT- 2016/11/15 06:00
MHDA- 2017/02/12 06:00
PMCR- 2016/10/20
CRDT- 2016/11/15 06:00
PHST- 2016/04/20 00:00 [received]
PHST- 2016/09/27 00:00 [accepted]
PHST- 2016/11/15 06:00 [entrez]
PHST- 2016/11/15 06:00 [pubmed]
PHST- 2017/02/12 06:00 [medline]
PHST- 2016/10/20 00:00 [pmc-release]
AID - 10.1155/2016/4727054 [doi]
PST - ppublish
SO  - Biomed Res Int. 2016;2016:4727054. doi: 10.1155/2016/4727054. Epub 2016 Oct 20.