PMID- 27841974
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20220331
IS  - 1759-9873 (Electronic)
IS  - 0964-5284 (Print)
IS  - 0964-5284 (Linking)
VI  - 34
IP  - 6
DP  - 2016 Dec
TI  - Effect of acupuncture 'dose' on modulation of the default mode network of the 
      brain.
PG  - 425-432
LID - 10.1136/acupmed-2016-011071 [doi]
AB  - OBJECTIVE: Recent functional MRI (fMRI) studies show that brain activity, 
      including the default mode network (DMN), can be modulated by acupuncture. 
      Conventional means to enhance the neurophysiological 'dose' of acupuncture, 
      including an increased number of needles and manual needle manipulation, are 
      expected to enhance its physiological effects. The aim of this study was to 
      compare the effects of both methods on brain activity. METHODS: 58 healthy 
      volunteers were randomly assigned into four groups that received single needle 
      acupuncture (SNA, n=15) or transcutaneous electrical nerve stimulation (TENS, 
      n=13) as active controls, or enhanced acupuncture by way of three needle 
      acupuncture (TNA, n=17) or SNA plus manual stimulation (SNA+MS, n=13). 
      Treatment-associated sensations were evaluated using a visual analogue scale. 
      Central responses were recorded before, during, and after treatment at LI4 on the 
      left hand using resting state fMRI. RESULTS: TNA and SNA+MS induced DMN-insula 
      activity and extensive DMN activity compared to SNA, despite comparable levels of 
      de qi sensation. The TNA and SNA+MS groups exhibited a delayed and enhanced 
      modulation of the DMN, which was not observed followed SNA and TENS. Furthermore, 
      TNA increased precuneus activity and increased the DMN-related activity of the 
      cuneus and left insula, while SNA+MS increased activity in the right insula. 
      CONCLUSIONS: The results showed that conventional methods to enhance the 
      acupuncture dose induce different DMN modulatory effects. TNA induces the most 
      extensive DMN modulation, compared with other methods. Conventional methods of 
      enhancing the acupuncture dose could potentially be applied as a means of 
      modulating brain activity.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://www.bmj.com/company/products-services/rights-and-licensing/.
FAU - Lin, Yii-Jeng
AU  - Lin YJ
AD  - Institute of Traditional Medicine, school of medicine, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Kung, Yen-Ying
AU  - Kung YY
AD  - Institute of Traditional Medicine, school of medicine, National Yang-Ming 
      University, Taipei, Taiwan.
AD  - Center for Traditional Medicine, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
FAU - Kuo, Wen-Jui
AU  - Kuo WJ
AD  - Institute of Neuroscience, school of medicine, National Yang-Ming University, 
      Taipei, Taiwan.
AD  - Laboratory of Integrated Brain Research, Department of Medical Research and 
      Education, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Niddam, David M
AU  - Niddam DM
AD  - Laboratory of Integrated Brain Research, Department of Medical Research and 
      Education, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - Institute of Brain Science, School of Medicine, National Yang-Ming, University, 
      Taipei, Taiwan.
FAU - Chou, Chih-Che
AU  - Chou CC
AD  - Laboratory of Integrated Brain Research, Department of Medical Research and 
      Education, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Cheng, Chou-Ming
AU  - Cheng CM
AD  - Laboratory of Integrated Brain Research, Department of Medical Research and 
      Education, Taipei Veterans General Hospital, Taipei, Taiwan.
FAU - Yeh, Tzu-Chen
AU  - Yeh TC
AD  - Laboratory of Integrated Brain Research, Department of Medical Research and 
      Education, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - Institute of Brain Science, School of Medicine, National Yang-Ming, University, 
      Taipei, Taiwan.
FAU - Hsieh, Jen-Chuen
AU  - Hsieh JC
AD  - Laboratory of Integrated Brain Research, Department of Medical Research and 
      Education, Taipei Veterans General Hospital, Taipei, Taiwan.
AD  - Institute of Brain Science, School of Medicine, National Yang-Ming, University, 
      Taipei, Taiwan.
FAU - Chiu, Jen-Hwey
AU  - Chiu JH
AD  - Institute of Traditional Medicine, school of medicine, National Yang-Ming 
      University, Taipei, Taiwan.
AD  - Division of General Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161006
PL  - England
TA  - Acupunct Med
JT  - Acupuncture in medicine : journal of the British Medical Acupuncture Society
JID - 9304117
SB  - IM
MH  - Acupuncture Therapy/instrumentation/*methods
MH  - Adult
MH  - Brain/diagnostic imaging/physiology
MH  - Brain Mapping/methods
MH  - Female
MH  - Hand/diagnostic imaging/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Needles
MH  - Nerve Net/*physiology
MH  - Rest/physiology
MH  - Sensation/*physiology
MH  - Transcutaneous Electric Nerve Stimulation/methods
MH  - Visual Analog Scale
PMC - PMC5256125
OTO - NOTNLM
OT  - *ACUPUNCTURE
OT  - *NEUROLOGY
COIS- Conflicts of Interest: None declared.
EDAT- 2016/11/15 06:00
MHDA- 2017/02/24 06:00
PMCR- 2017/01/23
CRDT- 2016/11/15 06:00
PHST- 2016/09/17 00:00 [accepted]
PHST- 2016/11/15 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
PHST- 2016/11/15 06:00 [entrez]
PHST- 2017/01/23 00:00 [pmc-release]
AID - acupmed-2016-011071 [pii]
AID - 10.1136/acupmed-2016-011071 [doi]
PST - ppublish
SO  - Acupunct Med. 2016 Dec;34(6):425-432. doi: 10.1136/acupmed-2016-011071. Epub 2016 
      Oct 6.