PMID- 27843555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2052-4897 (Print)
IS  - 2052-4897 (Electronic)
IS  - 2052-4897 (Linking)
VI  - 4
IP  - 1
DP  - 2016
TI  - Evaluation of vitamin D relationship with type 2 diabetes and systolic blood 
      pressure.
PG  - e000285
LID - e000285
AB  - OBJECTIVE: To investigate whether relationships exist among vitamin D, type 2 
      diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. 
      RESEARCH DESIGN AND METHODS: This was a case-controlled study to determine if 
      vitamin D levels were lower in patients with T2DM. After data analysis, an 
      exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) 
      was developed. Plasma calcifediol (25(OH)D) concentrations were used as a 
      measurement for vitamin D levels and were determined by ELISA. Cholesterol levels 
      were measured by an automated dry chemistry analyzer and blood pressure was 
      measured using an automatic blood pressure monitor. RESULTS: There was no 
      significant difference (p=0.139, n=76) in 25(OH)D levels between patients with 
      T2DM and controls. Subjects with SBP above 130 mm Hg were 8 times more likely to 
      have a 25(OH)D plasma concentration above 25 ng/mL (OR 7.9 (2.2 to 28.7)), and 
      were 5 times (OR 4.7 (1.7 to 15.1)) more likely to have a 25(OH)D plasma 
      concentration above 30 ng/mL (OR 7.5 (2.3-24.2)). Vitamin D levels moderately and 
      positively correlated with SBP (r(s)=0.38, p=0.001). CONCLUSIONS: There was no 
      significant difference in the 25(OH)D levels between patients with T2DM and 
      controls (p=0.139). Patients with SBP under 130 mm Hg were 8 times more likely to 
      have a vitamin D level above 25 ng/mL (OR 7.9 (2.2 to 28.7)). Further 
      investigations are required to examine the relationship between vitamin D and 
      SBP.
FAU - Nayak, Shivananda Bijoor
AU  - Nayak SB
AD  - Faculty of Medical Sciences, Department of Preclinical Sciences, St Augustine , 
      Trinidad.
FAU - Ramnanansingh, Terry Gavaskar
AU  - Ramnanansingh TG
AUID- ORCID: 0000-0002-4518-7337
AD  - Faculty of Medical Sciences, Department of Preclinical Sciences, St Augustine , 
      Trinidad.
LA  - eng
PT  - Journal Article
DEP - 20161010
PL  - England
TA  - BMJ Open Diabetes Res Care
JT  - BMJ open diabetes research & care
JID - 101641391
PMC - PMC5073486
OTO - NOTNLM
OT  - Blood Pressure
OT  - Type 2 Diabetes
OT  - Vitamin D
COIS- Conflicts of Interest: None declared.
EDAT- 2016/11/16 06:00
MHDA- 2016/11/16 06:01
PMCR- 2016/10/10
CRDT- 2016/11/16 06:00
PHST- 2016/06/20 00:00 [received]
PHST- 2016/08/19 00:00 [revised]
PHST- 2016/09/05 00:00 [accepted]
PHST- 2016/11/16 06:00 [entrez]
PHST- 2016/11/16 06:00 [pubmed]
PHST- 2016/11/16 06:01 [medline]
PHST- 2016/10/10 00:00 [pmc-release]
AID - bmjdrc-2016-000285 [pii]
AID - 10.1136/bmjdrc-2016-000285 [doi]
PST - epublish
SO  - BMJ Open Diabetes Res Care. 2016 Oct 10;4(1):e000285. doi: 
      10.1136/bmjdrc-2016-000285. eCollection 2016.