PMID- 27847627
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2056-9920 (Print)
IS  - 2056-9920 (Electronic)
IS  - 2056-9920 (Linking)
VI  - 2
DP  - 2016
TI  - Visual response and anatomical changes on sequential spectral-domain optical 
      coherence tomography in birdshot chorioretinopathy treated with local 
      corticosteroid therapy.
PG  - 9
LID - 10.1186/s40942-016-0034-y [doi]
LID - 9
AB  - BACKGROUND: Birdshot chorioretinopathy is a chronic bilateral inflammatory 
      disease of unknown etiology characterized by bilateral retinal vasculitis, mild 
      to moderate vitritis, retinal vascular leakage, cystoid macular edema (CME), and 
      typical "birdshot" chorioretinal lesions. Typically, patients with birdshot 
      chorioretinopathy are treated with systemic immunosuppressive and/or 
      corticosteroid therapy in an effort to minimize loss of vision. Spectral-domain 
      OCT (SD-OCT) has shown regional or generalized photoreceptor loss in addition to 
      both retinal as well as choroidal thinning in these patients. The present study 
      describes anatomical changes of the retina and alterations in choroidal thickness 
      and vasculature on sequential spectral-domain optical coherence tomography 
      (SD-OCT) in 4 patients with birdshot chorioretinopathy treated with local 
      corticosteroids. METHODS: A retrospective observational case series identified 4 
      consecutive patients (8 eyes) at New England Eye Center, Boston diagnosed with 
      birdshot chorioretinopathy according to the research criteria of the 
      international consensus conference that were managed by a single retina 
      specialist and treated exclusively with local corticosteroid therapy 
      (intravitreal/sub-tenon injections) without systemic immunosuppression. All 
      patients underwent longitudinal SD-OCT imaging with both the 512 x 128 cube scan 
      and the 1-line raster protocol. A chart review was performed to review the visual 
      response to treatment. Two independent observers analyzed sequential SD-OCT 
      images for retinal parameters such as occurrence of CME at any time during the 
      course of disease, presence of retinal thinning and presence of hyper-reflective 
      foci within the retina, and choroidal parameters including its thickness and its 
      vasculature. RESULTS: Mean age of the patients at diagnosis was 47 years 
      (26-60 years). Mean duration of follow-up was 96 months. All patients were 
      HLA-A29 positive. Visual acuity remained stable in 75 % of eyes, 63 % eyes had 
      central retinal thinning, 75 % eyes had hyper reflective foci within the retina 
      and 75 % eyes had CME during follow-up. Mean total sub-foveal choroidal thickness 
      of all 8 eyes at the time of the last SD-OCT was significantly lower than at 
      initial SD-OCT (p = 0.03). CONCLUSIONS: This case series suggests that treatment 
      with local corticosteroids may have good visual outcome despite retinal and 
      choroidal thinning. Future longitudinal studies are necessary to further 
      determine the benefits of local corticosteroid therapy.
FAU - Gobuty, Marisa
AU  - Gobuty M
AD  - New England Eye Center, Tufts University School of Medicine, 800 Washington 
      Street, Boston, MA 02111 USA. GRID: grid.429997.8. ISNI: 0000000419367531
FAU - Adhi, Mehreen
AU  - Adhi M
AD  - New England Eye Center, Tufts University School of Medicine, 800 Washington 
      Street, Boston, MA 02111 USA. GRID: grid.429997.8. ISNI: 0000000419367531
AD  - Department of Electrical Engineering, Massachusetts Institute of Technology, 
      Cambridge, MA USA. GRID: grid.116068.8. ISNI: 0000000123412786
FAU - Read, Sarah P
AU  - Read SP
AD  - New England Eye Center, Tufts University School of Medicine, 800 Washington 
      Street, Boston, MA 02111 USA. GRID: grid.429997.8. ISNI: 0000000419367531
FAU - Duker, Jay S
AU  - Duker JS
AD  - New England Eye Center, Tufts University School of Medicine, 800 Washington 
      Street, Boston, MA 02111 USA. GRID: grid.429997.8. ISNI: 0000000419367531
LA  - eng
PT  - Journal Article
DEP - 20160220
PL  - England
TA  - Int J Retina Vitreous
JT  - International journal of retina and vitreous
JID - 101677897
PMC - PMC5088458
OTO - NOTNLM
OT  - Birdshot chorioretinopathy
OT  - Choroidal thickness
OT  - Choroidal thinning
OT  - Choroidal vasculature
OT  - Corticosteroids
OT  - Cystoid macular edema
OT  - Immunosuppression
OT  - Retinal thinning
OT  - Spectral-domain optical coherence tomography
EDAT- 2016/11/17 06:00
MHDA- 2016/11/17 06:01
PMCR- 2016/02/20
CRDT- 2016/11/17 06:00
PHST- 2015/12/08 00:00 [received]
PHST- 2016/02/06 00:00 [accepted]
PHST- 2016/11/17 06:00 [entrez]
PHST- 2016/11/17 06:00 [pubmed]
PHST- 2016/11/17 06:01 [medline]
PHST- 2016/02/20 00:00 [pmc-release]
AID - 34 [pii]
AID - 10.1186/s40942-016-0034-y [doi]
PST - epublish
SO  - Int J Retina Vitreous. 2016 Feb 20;2:9. doi: 10.1186/s40942-016-0034-y. 
      eCollection 2016.