PMID- 27852303
OWN - NLM
STAT- MEDLINE
DCOM- 20170116
LR  - 20191210
IS  - 1472-6882 (Electronic)
IS  - 1472-6882 (Linking)
VI  - 16
IP  - 1
DP  - 2016 Nov 16
TI  - The effects of Nigella sativa on thyroid function, serum Vascular Endothelial 
      Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with 
      Hashimoto's thyroiditis: a randomized controlled trial.
PG  - 471
LID - 471
AB  - BACKGROUND: Hashimoto's thyroiditis is an autoimmune disorder and the most common 
      cause of hypothyroidism. The use of Nigella sativa, a potent herbal medicine, 
      continues to increase worldwide as an alternative treatment of several chronic 
      diseases including hyperlipidemia, hypertension and type 2 diabetes mellitus 
      (T2DM). The aim of the current study was to evaluate the effects of Nigella 
      sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, 
      Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis. 
      METHODS: Forty patients with Hashimoto's thyroiditis, aged between 22 and 
      50 years old, participated in the trial and were randomly allocated into two 
      groups of intervention and control receiving powdered Nigella sativa or placebo 
      daily for 8 weeks. Changes in anthropometric variables, dietary intakes, thyroid 
      status, serum VEGF and Nesfatin-1 concentrations after 8 weeks were measured. 
      RESULTS: Treatment with Nigella sativa significantly reduced body weight and body 
      mass index (BMI). Serum concentrations of thyroid stimulating hormone (TSH) and 
      anti-thyroid peroxidase (anti-TPO) antibodies decreased while serum T3 
      concentrations increased in Nigella sativa-treated group after 8 weeks. There was 
      a significant reduction in serum VEGF concentrations in intervention group. None 
      of these changes had been observed in placebo treated group. In stepwise multiple 
      regression model, changes in waist to hip ratio (WHR) and thyroid hormones were 
      significant predictors of changes in serum VEGF and Nesgfatin-1 values in Nigella 
      sativa treated group (P < 0.05). CONCLUSIONS: Our data showed a potent beneficial 
      effect of powdered Nigella sativa in improving thyroid status and anthropometric 
      variables in patients with Hashimoto's thyroiditis. Moreover, Nigella sativa 
      significantly reduced serum VEGF concentrations in these patients. Considering 
      observed health- promoting effect of this medicinal plant in ameliorating the 
      disease severity, it can be regarded as a useful therapeutic approach in 
      management of Hashimoto's thyroiditis. TRIAL REGISTRATION: Iranian registry of 
      clinical trials (registration number IRCT2015021719082N4 - Registered 
      March-15-2015).
FAU - Farhangi, Mahdieh Abbasalizad
AU  - Farhangi MA
AD  - Nutrition Research Center, Department of Community Nutrition, School of 
      Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. 
      abbasalizad_m@yahoo.com.
FAU - Dehghan, Parvin
AU  - Dehghan P
AD  - Nutrition Research Center, Department of Community Nutrition, School of 
      Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Tajmiri, Siroos
AU  - Tajmiri S
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Abbasi, Mehran Mesgari
AU  - Abbasi MM
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20161116
PL  - England
TA  - BMC Complement Altern Med
JT  - BMC complementary and alternative medicine
JID - 101088661
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NUCB2 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nucleobindins)
RN  - 0 (Plant Extracts)
RN  - 0 (Thyroid Hormones)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Anthropometry
MH  - Body Weight
MH  - Calcium-Binding Proteins/*blood
MH  - DNA-Binding Proteins/*blood
MH  - Female
MH  - Hashimoto Disease/blood/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*blood
MH  - Nigella sativa/*chemistry
MH  - Nucleobindins
MH  - Plant Extracts/*administration & dosage
MH  - Thyroid Gland/*metabolism
MH  - Thyroid Hormones/blood
MH  - Vascular Endothelial Growth Factor A/*blood
MH  - Waist-Hip Ratio
MH  - Young Adult
PMC - PMC5112739
OTO - NOTNLM
OT  - Hashimoto's thyroiditis
OT  - Nesfatin-1
OT  - Nigella sativa
OT  - VEGF
EDAT- 2016/11/18 06:00
MHDA- 2017/01/17 06:00
PMCR- 2016/11/16
CRDT- 2016/11/18 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/11/02 00:00 [accepted]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2017/01/17 06:00 [medline]
PHST- 2016/11/16 00:00 [pmc-release]
AID - 10.1186/s12906-016-1432-2 [pii]
AID - 1432 [pii]
AID - 10.1186/s12906-016-1432-2 [doi]
PST - epublish
SO  - BMC Complement Altern Med. 2016 Nov 16;16(1):471. doi: 10.1186/s12906-016-1432-2.