PMID- 27852304
OWN - NLM
STAT- MEDLINE
DCOM- 20170407
LR  - 20181113
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 15
IP  - 1
DP  - 2016 Nov 16
TI  - Echocardiographic epicardial fat thickness is a predictor for target vessel 
      revascularization in patients with ST-elevation myocardial infarction.
PG  - 194
LID - 194
AB  - BACKGROUND: The amount of epicardial adipose tissue (EAT) has been demonstrated 
      to correlate with the severity of coronary artery disease (CAD) and the CAD 
      activity. The aim of this study is to assess the impact of EAT on long term 
      clinical outcomes in patients with ST elevation myocardial infarction (STEMI) 
      after percutaneous coronary intervention (PCI). METHODS: We analyzed the data and 
      clinical outcomes of 761 patients (614 males, 57 +/- 12 year-old) with STEMI who 
      underwent successful primary PCI from 2003 to 2009. All patients were divided 
      into two groups: thick EAT group, EAT >/= 3.5 mm and thin EAT group, EAT < 3.5 mm. 
      The primary end points were all-cause death, recurrent MI, target vessel 
      revascularization (TVR) and major cardiac adverse events (MACEs), composite of 
      all-cause death, recurrent MI and TVR, within 5 years. RESULTS: Median and mean 
      EAT of 761 patients were 3.3 mm and 3.6 +/- 1.7 mm, respectively. Mean follow up 
      period was 46 +/- 18 months. MACE-free survival rate in the thick EAT group was 
      significantly lower than in the thin EAT group (log-rank P = 0.001). The 
      event-free survival rate of all-cause death of the thick EAT group was 
      significantly lower than that of the thin EAT group (log-rank P = 0.005). The 
      TVR-free survival rate in the thick EAT group was significantly lower than in the 
      thin EAT group (log-rank P = 0.007). The event-free survival rate of recurrent MI 
      were not significantly different between the groups (log-rank P = 0.206). In the 
      Cox's proportional hazard model, the adjusted hazard ratio of thick EAT thickness 
      for TVR was 1.868 (95% confidence interval 1.181-2.953, P = 0.008). CONCLUSION: 
      This study demonstrates that the EAT thickness is related with long term clinical 
      outcome in patients with STEMI. The EAT thickness might provide additional 
      information for future clinical outcome, especially TVR.
FAU - Park, Jin-Sun
AU  - Park JS
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Lee, You-Hong
AU  - Lee YH
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Seo, Kyoung-Woo
AU  - Seo KW
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Choi, Byoung-Joo
AU  - Choi BJ
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Choi, So-Yeon
AU  - Choi SY
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Yoon, Myeong-Ho
AU  - Yoon MH
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Hwang, Gyo-Seung
AU  - Hwang GS
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Tahk, Seung-Jea
AU  - Tahk SJ
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea.
FAU - Shin, Joon-Han
AU  - Shin JH
AD  - Department of Cardiology, Ajou University School of Medicine, 164 Worldcup-ro, 
      Yeongtong-gu, Suwon, 16499, Korea. shinjh@ajou.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20161116
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
SB  - IM
MH  - Adipose Tissue/*diagnostic imaging/pathology
MH  - Adult
MH  - Aged
MH  - Disease-Free Survival
MH  - Echocardiography
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Percutaneous Coronary Intervention
MH  - Pericardium/*diagnostic imaging/pathology
MH  - Proportional Hazards Models
MH  - ST Elevation Myocardial Infarction/diagnostic imaging/pathology/*surgery
MH  - Treatment Outcome
PMC - PMC5112651
OTO - NOTNLM
OT  - Epicardial adipose tissue
OT  - Myocardial Infarction
OT  - Prognosis
EDAT- 2016/11/18 06:00
MHDA- 2017/04/08 06:00
PMCR- 2016/11/16
CRDT- 2016/11/18 06:00
PHST- 2016/08/06 00:00 [received]
PHST- 2016/11/10 00:00 [accepted]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2017/04/08 06:00 [medline]
PHST- 2016/11/16 00:00 [pmc-release]
AID - 10.1186/s12944-016-0371-8 [pii]
AID - 371 [pii]
AID - 10.1186/s12944-016-0371-8 [doi]
PST - epublish
SO  - Lipids Health Dis. 2016 Nov 16;15(1):194. doi: 10.1186/s12944-016-0371-8.