PMID- 27853149
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20191008
IS  - 1476-5527 (Electronic)
IS  - 0950-9240 (Print)
IS  - 0950-9240 (Linking)
VI  - 31
IP  - 5
DP  - 2017 May
TI  - Factors associated with false-positive self-reported adherence to 
      antihypertensive drugs.
PG  - 320-326
LID - 10.1038/jhh.2016.80 [doi]
AB  - Self-reported medication adherence is known to overestimate true adherence. 
      However, little is known about patient factors that may contribute to the upward 
      bias in self-reported medication adherence. The objective of this study is to 
      examine whether demographic, behavioral, medication and mood factors are 
      associated with being a false-positive self-reported adherer (FPA) to 
      antihypertensive drug treatment. We studied 175 patients (mean age: 50 years; 57% 
      men) from primary-care clinics starting antihypertensive drug treatment. 
      Self-reported adherence (SRA) was measured with the Medication Adherence Report 
      Scale (MARS) and by the number of drug doses missed in the previous week/month, 
      and compared with pill count adherence ratio (PCAR) as gold standard. Data on 
      adherence, demographic, behavioral, medication and mood factors were collected at 
      baseline and every 3 months up to 1 year. FPA was defined as being a non-adherer 
      by PCAR and an adherer by self-report. Mixed effect logistic regression was used 
      for the analysis. Twenty percent of participants were FPA. Anxiety increased 
      (odds ratio (OR): 3.00; P=0.01), whereas smoking (OR: 0.40; P=0.03) and drug side 
      effects (OR: 0.46, P=0.03) decreased the probability for FPA by MARS. Education 
      below high-school completion increased the probability of being an FPA as 
      measured by missing doses in the last month (OR: 1.66; P=0.04) and last week (OR: 
      1.88; P=0.02). The validity of SRA varies significantly according to drug side 
      effects, behavioral factors and patient's mood. Careful consideration should be 
      given to the use of self-reported measures of adherence among patients likely to 
      be false-positive adherers.
FAU - Tedla, Y G
AU  - Tedla YG
AD  - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern 
      University, Chicago, IL, USA.
FAU - Bautista, L E
AU  - Bautista LE
AD  - Department of Population Health Sciences, University of Wisconsin at Madison, 
      Madison, WI, USA.
LA  - eng
GR  - P2C HD047873/HD/NICHD NIH HHS/United States
GR  - UL1 RR025011/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20161117
PL  - England
TA  - J Hum Hypertens
JT  - Journal of human hypertension
JID - 8811625
RN  - 0 (Antihypertensive Agents)
SB  - IM
MH  - *Affect
MH  - Antihypertensive Agents/*therapeutic use
MH  - Demography
MH  - Educational Status
MH  - Female
MH  - Humans
MH  - *Hypertension/drug therapy/epidemiology/psychology
MH  - Male
MH  - *Medication Adherence/psychology/statistics & numerical data
MH  - Middle Aged
MH  - Observer Variation
MH  - Risk Factors
MH  - Self Report
MH  - United States/epidemiology
PMC - PMC6062205
MID - NIHMS981805
COIS- Conflicting Interests: The authors declared no potential conflicts of interest.
EDAT- 2016/11/18 06:00
MHDA- 2018/02/21 06:00
PMCR- 2018/07/26
CRDT- 2016/11/18 06:00
PHST- 2016/05/08 00:00 [received]
PHST- 2016/09/30 00:00 [revised]
PHST- 2016/10/10 00:00 [accepted]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2018/07/26 00:00 [pmc-release]
AID - jhh201680 [pii]
AID - 10.1038/jhh.2016.80 [doi]
PST - ppublish
SO  - J Hum Hypertens. 2017 May;31(5):320-326. doi: 10.1038/jhh.2016.80. Epub 2016 Nov 
      17.