PMID- 27853243
OWN - NLM
STAT- MEDLINE
DCOM- 20180501
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Nov 17
TI  - Axin2-expressing cells execute regeneration after skeletal injury.
PG  - 36524
LID - 10.1038/srep36524 [doi]
LID - 36524
AB  - The mammalian skeleton performs a diverse range of vital functions, requiring 
      mechanisms of regeneration that restore functional skeletal cell populations 
      after injury. We hypothesized that the Wnt pathway specifies distinct functional 
      subsets of skeletal cell types, and that lineage tracing of Wnt-responding cells 
      (WRCs) using the Axin2 gene in mice identifies a population of long-lived 
      skeletal cells on the periosteum of long bone. Ablation of these WRCs disrupts 
      healing after injury, and three-dimensional finite element modeling of the 
      regenerate delineates their essential role in functional bone regeneration. These 
      progenitor cells in the periosteum are activated upon injury and give rise to 
      both cartilage and bone. Indeed, our findings suggest that WRCs may serve as a 
      therapeutic target in the setting of impaired skeletal regeneration.
FAU - Ransom, R C
AU  - Ransom RC
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
AD  - Institute for Stem Cell Biology and Regenerative Medicine, Stanford University 
      School of Medicine, Stanford, CA 94305, USA.
FAU - Hunter, D J
AU  - Hunter DJ
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Hyman, S
AU  - Hyman S
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Singh, G
AU  - Singh G
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Ransom, S C
AU  - Ransom SC
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Shen, E Z
AU  - Shen EZ
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Perez, K C
AU  - Perez KC
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Gillette, M
AU  - Gillette M
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Li, J
AU  - Li J
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Liu, B
AU  - Liu B
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Brunski, J B
AU  - Brunski JB
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
FAU - Helms, J A
AU  - Helms JA
AD  - Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and 
      Reconstructive Surgery, Department of Surgery, Stanford University School of 
      Medicine, Stanford, CA 94305-5148, USA.
LA  - eng
PT  - Journal Article
DEP - 20161117
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Axin Protein)
RN  - 0 (Axin2 protein, mouse)
SB  - IM
MH  - Animals
MH  - Axin Protein/genetics/*metabolism
MH  - Bone and Bones/*cytology/*injuries
MH  - Cell Lineage
MH  - Cell Proliferation
MH  - Finite Element Analysis
MH  - *Liver Regeneration
MH  - Mice
MH  - Models, Theoretical
MH  - Wnt Signaling Pathway
PMC - PMC5113299
EDAT- 2016/11/18 06:00
MHDA- 2018/05/02 06:00
PMCR- 2016/11/17
CRDT- 2016/11/18 06:00
PHST- 2016/01/30 00:00 [received]
PHST- 2016/10/18 00:00 [accepted]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2018/05/02 06:00 [medline]
PHST- 2016/11/17 00:00 [pmc-release]
AID - srep36524 [pii]
AID - 10.1038/srep36524 [doi]
PST - epublish
SO  - Sci Rep. 2016 Nov 17;6:36524. doi: 10.1038/srep36524.