PMID- 27853680
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2228-5652 (Print)
IS  - 2228-5660 (Electronic)
IS  - 2228-5652 (Linking)
VI  - 6
IP  - 3
DP  - 2016
TI  - Radiolabeled theranostics: magnetic and gold nanoparticles.
PG  - 169-181
AB  - Introduction: Growing advances in nanotechnology have facilitated the 
      applications of newly emerged nanomaterials in the field of 
      biomedical/pharmaceutical sciences. Following this trend, the multifunctional 
      nanoparticles (NPs) play a significant role in development of advanced drug 
      delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous 
      diagnosis and therapy. Multifunctional radiolabeled NPs with capability of 
      detecting, visualizing and destroying diseased cells with least side effects have 
      been considered as an emerging filed in presentation of the best choice in 
      solving the therapeutic problems. Functionalized magnetic and gold NPs (MNPs and 
      GNPs, respectively) have produced the potential of nanoparticles as sensitive 
      multifunctional probes for molecular imaging, photothermal therapy and drug 
      delivery and targeting. Methods: In this study, we review the most recent works 
      on the improvement of various techniques for development of radiolabeled magnetic 
      and gold nanoprobes, and discuss the methods for targeted imaging and therapies. 
      Results: The receptor-specific radiopharmaceuticals have been developed to 
      localized radiotherapy in disease sites. Application of advanced multimodal 
      imaging methods and related modality imaging agents labeled with various 
      radioisotopes (e.g., (125)I, (111)In, (64)Cu, (68)Ga, (99)mTc) and MNPs/GNPs have 
      significant effects on treatment and prognosis of cancer therapy. In addition, 
      the surface modification with biocompatible polymer such as polyethylene glycol 
      (PEG) have resulted in development of stealth NPs that can evade the opsonization 
      and immune clearance. These long-circulating agents can be decorated with homing 
      agents as well as radioisotopes for targeted imaging and therapy purposes. 
      Conclusion: The modified MNPs or GNPs have wide applications in concurrent 
      diagnosis and therapy of various malignancies. Once armed with radioisotopes, 
      these nanosystems (NSs) can be exploited for combined multimodality imaging with 
      photothermal/photodynamic therapy while delivering the loaded drugs or genes to 
      the targeted cells/tissues. These NSs will be a game changer in combating various 
      cancers.
FAU - Same, Saeideh
AU  - Same S
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Aghanejad, Ayuob
AU  - Aghanejad A
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Akbari Nakhjavani, Sattar
AU  - Akbari Nakhjavani S
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran ; Department of Molecular Medicine, School of Advanced 
      Technologies in Medicine, International Campus, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Barar, Jaleh
AU  - Barar J
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Omidi, Yadollah
AU  - Omidi Y
AD  - Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical 
      Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20160930
PL  - Iran
TA  - Bioimpacts
JT  - BioImpacts : BI
JID - 101558125
PMC - PMC5108989
OTO - NOTNLM
OT  - Nuclear imaging
OT  - PET/SPECT
OT  - Radiolabeled nanoparticles
OT  - Theranostics
EDAT- 2016/11/18 06:00
MHDA- 2016/11/18 06:01
PMCR- 2016/01/01
CRDT- 2016/11/18 06:00
PHST- 2016/08/12 00:00 [received]
PHST- 2016/09/21 00:00 [revised]
PHST- 2016/09/27 00:00 [accepted]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2016/11/18 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.15171/bi.2016.23 [doi]
PST - ppublish
SO  - Bioimpacts. 2016;6(3):169-181. doi: 10.15171/bi.2016.23. Epub 2016 Sep 30.