PMID- 27853993
OWN - NLM
STAT- MEDLINE
DCOM- 20170414
LR  - 20210320
IS  - 1995-820X (Electronic)
IS  - 1674-0769 (Print)
IS  - 1995-820X (Linking)
VI  - 32
IP  - 1
DP  - 2017 Feb
TI  - The roles of ebolavirus glycoproteins in viral pathogenesis.
PG  - 3-15
LID - 10.1007/s12250-016-3850-1 [doi]
AB  - Ebolaviruses are highly dangerous pathogens exhibiting extreme virulence in 
      humans and nonhuman primates. The majority of ebolavirus species, most notably 
      Zaire ebolavirus, can cause Ebola virus disease (EVD), formerly known as Ebola 
      hemorrhagic fever, in humans. EVD is associated with case-fatality rates as high 
      as 90%, and there is currently no specific treatment or licensed vaccine 
      available against EVD. Understanding the molecular biology and pathogenesis of 
      ebolaviruses is important for the development of antiviral therapeutics. 
      Ebolavirus encodes several forms of glycoproteins (GPs), which have some 
      interesting characteristics, including the transcriptional editing coding 
      strategy and extensive O-glycosylation modification, clustered in the mucin-like 
      domain of GP1, full-length GP (GP(1,2)), and shed GP. In addition to the 
      canonical role of the spike protein, GP(1,2), in viral entry, ebolavirus GPs 
      appear to have multiple additional functions, likely contributing to the complex 
      pathogenesis of the virus. Here, we review the roles of ebolavirus GPs in viral 
      pathogenesis.
FAU - Ning, Yun-Jia
AU  - Ning YJ
AD  - State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of 
      Sciences, Wuhan, 430071, China.
FAU - Deng, Fei
AU  - Deng F
AD  - State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of 
      Sciences, Wuhan, 430071, China.
FAU - Hu, Zhihong
AU  - Hu Z
AD  - State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of 
      Sciences, Wuhan, 430071, China.
FAU - Wang, Hualin
AU  - Wang H
AD  - State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of 
      Sciences, Wuhan, 430071, China. h.wang@wh.iov.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161114
PL  - Netherlands
TA  - Virol Sin
JT  - Virologica Sinica
JID - 101514185
RN  - 0 (Glycoproteins)
RN  - 0 (Viral Structural Proteins)
SB  - IM
MH  - Animals
MH  - Ebolavirus/*physiology
MH  - Glycoproteins/*metabolism
MH  - Hemorrhagic Fever, Ebola/*pathology/*virology
MH  - *Host-Pathogen Interactions
MH  - Humans
MH  - Viral Structural Proteins/*metabolism
MH  - Virus Internalization
MH  - Virus Replication
PMC - PMC6791933
OTO - NOTNLM
OT  - cytotoxicity
OT  - ebolavirus
OT  - glycoprotein (GP)
OT  - immune evasion
OT  - inflammation
OT  - mucin-like domain (MLD)
OT  - pathogenesis
EDAT- 2016/11/18 06:00
MHDA- 2017/04/15 06:00
PMCR- 2016/11/14
CRDT- 2016/11/18 06:00
PHST- 2016/08/03 00:00 [received]
PHST- 2016/10/09 00:00 [accepted]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2017/04/15 06:00 [medline]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2016/11/14 00:00 [pmc-release]
AID - 10.1007/s12250-016-3850-1 [pii]
AID - 3850 [pii]
AID - 10.1007/s12250-016-3850-1 [doi]
PST - ppublish
SO  - Virol Sin. 2017 Feb;32(1):3-15. doi: 10.1007/s12250-016-3850-1. Epub 2016 Nov 14.