PMID- 27854313
OWN - NLM
STAT- MEDLINE
DCOM- 20170724
LR  - 20221207
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 13
IP  - 11
DP  - 2016 Nov 15
TI  - Association between the Angiotensin-Converting Enzyme (ACE) Genetic Polymorphism 
      and Diabetic Retinopathy-A Meta-Analysis Comprising 10,168 Subjects.
LID - 1142
AB  - Aims-to address the inconclusive findings of the association of 
      angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism on risk 
      of diabetic retinopathy (DR), a meta-analysis was conducted. Methods-we conducted 
      a meta-analysis on 4252 DR cases and 5916 controls from 40 published studies by 
      searching electronic databases and reference lists of relevant articles. A 
      random-effects or fixed-effects model was used to estimate the overall and 
      stratification effect sizes on ACE I/D polymorphism on the risk of DR. Results-we 
      found a significant association between the ACE I/D polymorphism and the risk of 
      DR for all genetic model (ID vs. II: OR = 1.14, 95% CI: 1.00-1.30; DD vs. II: OR 
      = 1.38, 95% CI: 1.11-1.71; Allele contrast: OR = 1.17, 95% CI: 1.05-1.30; 
      recessive model: OR = 1.24, 95% CI: 1.02-1.51 and dominant model: OR = 1.21, 95% 
      CI: 1.06-1.38, respectively). In stratified analysis by ethnicity and DM type, we 
      further found that the Asian group with T2DM showed a significant association for 
      all genetic models (ID vs. II: OR = 1.14, 95% CI: 1.01-1.30; DD vs. II: OR = 
      1.54, 95% CI: 1.14-2.08; Allele contrast: OR = 1.26, 95% CI: 1.09-1.47; recessive 
      model: OR = 1.42, 95% CI: 1.07-1.88 and dominant model: OR = 1.26, 95% CI: 
      1.07-1.49, respectively). Conclusion-our study suggested that the ACE I/D 
      polymorphism may contribute to DR development, especially in the Asian group with 
      type 2 diabetes mellitus (T2DM). Prospective and more genome-wide association 
      studies (GWAS) are needed to clarify the real role of the ACE gene in determining 
      susceptibility to DR.
FAU - Luo, Shasha
AU  - Luo S
AD  - Department of Ophthalmology, Nanjing Medical University Affiliated Wuxi Second 
      Hospital, 68 Zhongshan Road, Wuxi 214002, China. luoshasha403@163.com.
FAU - Shi, Chao
AU  - Shi C
AD  - Wuxi Center for Disease Control and Prevention, 499 Jincheng Road, Wuxi 214023, 
      China. shichao.xo@163.com.
FAU - Wang, Furu
AU  - Wang F
AD  - Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, 
      Nanjing 210029, China. furuwang83@163.com.
FAU - Wu, Zhifeng
AU  - Wu Z
AD  - Department of Ophthalmology, Nanjing Medical University Affiliated Wuxi Second 
      Hospital, 68 Zhongshan Road, Wuxi 214002, China. zhifengwu2013@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20161115
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - EC 3.4.15.1 (ACE protein, human)
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Diabetic Retinopathy/*enzymology/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - Polymorphism, Genetic
MH  - Prospective Studies
MH  - Risk Assessment
PMC - PMC5129352
OTO - NOTNLM
OT  - ACE I/D
OT  - DM type
OT  - diabetic retinopathy
OT  - ethnicity
OT  - polymorphism
COIS- The authors declare no conflict of interest.
EDAT- 2016/11/18 06:00
MHDA- 2017/07/25 06:00
PMCR- 2016/11/01
CRDT- 2016/11/18 06:00
PHST- 2016/08/11 00:00 [received]
PHST- 2016/11/02 00:00 [revised]
PHST- 2016/11/02 00:00 [accepted]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2017/07/25 06:00 [medline]
PHST- 2016/11/01 00:00 [pmc-release]
AID - ijerph13111142 [pii]
AID - ijerph-13-01142 [pii]
AID - 10.3390/ijerph13111142 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2016 Nov 15;13(11):1142. doi: 
      10.3390/ijerph13111142.