PMID- 27854509
OWN - NLM
STAT- MEDLINE
DCOM- 20170630
LR  - 20181113
IS  - 1535-4989 (Electronic)
IS  - 1044-1549 (Print)
IS  - 1044-1549 (Linking)
VI  - 56
IP  - 4
DP  - 2017 Apr
TI  - Transforming Growth Factor beta1 Function in Airway Remodeling and 
      Hyperresponsiveness. The Missing Link?
PG  - 432-442
LID - 10.1165/rcmb.2016-0307TR [doi]
AB  - The pathogenesis of asthma includes a complex interplay among airway 
      inflammation, hyperresponsiveness, and remodeling. Current evidence suggests that 
      airway structural cells, including bronchial smooth muscle cells, myofibroblasts, 
      fibroblasts, and epithelial cells, mediate all three aspects of asthma 
      pathogenesis. Although studies show a connection between airway remodeling and 
      changes in bronchomotor tone, the relationship between the two remains unclear. 
      Transforming growth factor beta1 (TGF-beta1), a growth factor elevated in the airway of 
      patients with asthma, plays a role in airway remodeling and in the shortening of 
      various airway structural cells. However, the role of TGF-beta1 in mediating airway 
      hyperresponsiveness remains unclear. In this review, we summarize the literature 
      addressing the role of TGF-beta1 in airway remodeling and shortening. Through our 
      review, we aim to further elucidate the role of TGF-beta1 in asthma pathogenesis and 
      the link between airway remodeling and airway hyperresponsiveness in asthma and 
      to define TGF-beta1 as a potential therapeutic target for reducing asthma morbidity 
      and mortality.
FAU - Ojiaku, Christie A
AU  - Ojiaku CA
AUID- ORCID: 0000-0002-2592-6710
AD  - 1 Department of Systems Pharmacology and Translational Therapeutics, Perelman 
      School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.
AD  - 2 Rutgers Institute for Translational Medicine and Science, Child Health 
      Institute, Rutgers University, New Brunswick, New Jersey.
FAU - Yoo, Edwin J
AU  - Yoo EJ
AD  - 1 Department of Systems Pharmacology and Translational Therapeutics, Perelman 
      School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.
AD  - 2 Rutgers Institute for Translational Medicine and Science, Child Health 
      Institute, Rutgers University, New Brunswick, New Jersey.
FAU - Panettieri, Reynold A Jr
AU  - Panettieri RA Jr
AD  - 2 Rutgers Institute for Translational Medicine and Science, Child Health 
      Institute, Rutgers University, New Brunswick, New Jersey.
LA  - eng
GR  - P01 HL114471/HL/NHLBI NIH HHS/United States
GR  - T32 GM008076/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - Am J Respir Cell Mol Biol
JT  - American journal of respiratory cell and molecular biology
JID - 8917225
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - *Airway Remodeling
MH  - Animals
MH  - Humans
MH  - Lung/pathology
MH  - Models, Biological
MH  - Molecular Targeted Therapy
MH  - Respiratory Hypersensitivity/*metabolism/*physiopathology
MH  - Transforming Growth Factor beta1/*metabolism
PMC - PMC5449515
OTO - NOTNLM
OT  - airway epithelium
OT  - airway smooth muscle
OT  - bronchoconstriction
OT  - contraction
OT  - cytokines
EDAT- 2016/11/18 06:00
MHDA- 2017/07/01 06:00
PMCR- 2018/04/01
CRDT- 2016/11/18 06:00
PHST- 2016/11/18 06:00 [pubmed]
PHST- 2017/07/01 06:00 [medline]
PHST- 2016/11/18 06:00 [entrez]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 10.1165/rcmb.2016-0307TR [doi]
PST - ppublish
SO  - Am J Respir Cell Mol Biol. 2017 Apr;56(4):432-442. doi: 10.1165/rcmb.2016-0307TR.