PMID- 27855806 OWN - NLM STAT- MEDLINE DCOM- 20170630 LR - 20180927 IS - 1558-3597 (Electronic) IS - 0735-1097 (Linking) VI - 68 IP - 20 DP - 2016 Nov 15 TI - Long-Term Prognostic Value of Cardiac Magnetic Resonance in Left Ventricle Noncompaction: A Prospective Multicenter Study. PG - 2166-2181 LID - S0735-1097(16)35318-9 [pii] LID - 10.1016/j.jacc.2016.08.053 [doi] AB - BACKGROUND: Cardiac magnetic resonance (CMR) is useful for the diagnosis of left ventricular noncompaction (LVNC). However, there are limited data regarding its prognostic value. OBJECTIVES: The goal of this study was to evaluate the prognostic relevance of CMR findings in patients with LVNC. METHODS: A total of 113 patients with an echocardiographic diagnosis of LVNC underwent CMR at 5 referral centers. CMR diagnostic criterion of LVNC (noncompacted/compacted ratio >2.3 in end-diastole) was confirmed in all patients. We performed left ventricular (LV) and right ventricular quantitative analysis and late gadolinium enhancement (LGE) assessments and analyzed the following LVNC diagnostic criteria: left ventricular noncompacted myocardial mass (LV-ncMM) >20% and >25%, total LV-ncMM index >15 g/m(2), noncompacted/compacted ratio >/=3:1 >/=1 of segments 1 to 3 and 7 to 16 or >/=2:1 in at least 1 of segments 4 to 6 of the American Heart Association model. Outcome was a composite of thromboembolic events, heart failure hospitalizations, ventricular arrhythmias, and cardiac death. RESULTS: At a mean follow-up of 48 +/- 24 months, cardiac events (CEs) occurred in 36 patients (16 heart failure hospitalizations, 10 ventricular arrhythmias, 5 cardiac deaths, and 5 thromboembolic events). LV dilation, impaired LV ejection fraction, and LV-ncMM >20% was significantly more frequent in patients with CEs. LV fibrosis was detected by using LGE in 11 cases. CMR predictors of CEs were LV dilation and LGE. LGE was associated with improved prediction of CEs, compared with clinical data and CMR functional parameters in all 3 models. No CEs occurred in patients without dilated cardiomyopathy and/or LGE. CONCLUSIONS: In patients with LVNC evaluated by using CMR, the degree of LV trabeculation seems to have no prognostic impact over and above LV dilation, LV systolic dysfunction, and presence of LGE. CI - Copyright (c) 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Andreini, Daniele AU - Andreini D AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. Electronic address: daniele.andreini@ccfm.it. FAU - Pontone, Gianluca AU - Pontone G AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Bogaert, Jan AU - Bogaert J AD - Gasthuisberg University Hospital, Leuven, Belgium. FAU - Roghi, Alberto AU - Roghi A AD - Niguarda Ca Granda Hospital, Milan, Italy. FAU - Barison, Andrea AU - Barison A AD - Niguarda Ca Granda Hospital, Milan, Italy. FAU - Schwitter, Juerg AU - Schwitter J AD - Centre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland. FAU - Mushtaq, Saima AU - Mushtaq S AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Vovas, Georgios AU - Vovas G AD - Gasthuisberg University Hospital, Leuven, Belgium. FAU - Sormani, Paola AU - Sormani P AD - Niguarda Ca Granda Hospital, Milan, Italy. FAU - Aquaro, Giovanni D AU - Aquaro GD AD - Fondazione CNR-Regione Toscana 'G.Monasterio,' Pisa, Italy. FAU - Monney, Pierre AU - Monney P AD - Centre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland. FAU - Segurini, Chiara AU - Segurini C AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Guglielmo, Marco AU - Guglielmo M AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Conte, Edoardo AU - Conte E AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Fusini, Laura AU - Fusini L AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Dello Russo, Antonio AU - Dello Russo A AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Lombardi, Massimo AU - Lombardi M AD - Multimodality Cardiac Imaging Section, Policlinico San Donato, Milan, Italy. FAU - Gripari, Paola AU - Gripari P AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Baggiano, Andrea AU - Baggiano A AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Fiorentini, Cesare AU - Fiorentini C AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy. FAU - Lombardi, Federico AU - Lombardi F AD - Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy; Department of Cardiovascular Disease, Ospedale Maggiore Policlinico, Milan, Italy. FAU - Bartorelli, Antonio L AU - Bartorelli AL AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy; Department of Biomedical and Clinical Sciences "Luigi Sacco," University of Milan, Milan, Italy. FAU - Pepi, Mauro AU - Pepi M AD - Centro Cardiologico Monzino, IRCCS, Milan, Italy. FAU - Masci, Pier Giorgio AU - Masci PG AD - Centre for Cardiac MR, Cardiology Department, University Hospital Lausanne, Lausanne, Switzerland. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't PL - United States TA - J Am Coll Cardiol JT - Journal of the American College of Cardiology JID - 8301365 SB - IM CIN - J Am Coll Cardiol. 2016 Nov 15;68(20):2182-2184. PMID: 27855807 MH - Adult MH - Disease Progression MH - Echocardiography MH - Female MH - Follow-Up Studies MH - Heart Ventricles/*diagnostic imaging MH - Humans MH - Isolated Noncompaction of the Ventricular Myocardium/*diagnosis MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - Reproducibility of Results MH - Time Factors OTO - NOTNLM OT - cardiac magnetic resonance OT - dilated cardiomyopathy OT - late gadolinium enhancement OT - left ventricular noncompaction OT - prognosis EDAT- 2016/11/20 06:00 MHDA- 2017/07/01 06:00 CRDT- 2016/11/19 06:00 PHST- 2016/04/02 00:00 [received] PHST- 2016/08/23 00:00 [revised] PHST- 2016/08/31 00:00 [accepted] PHST- 2016/11/19 06:00 [entrez] PHST- 2016/11/20 06:00 [pubmed] PHST- 2017/07/01 06:00 [medline] AID - S0735-1097(16)35318-9 [pii] AID - 10.1016/j.jacc.2016.08.053 [doi] PST - ppublish SO - J Am Coll Cardiol. 2016 Nov 15;68(20):2166-2181. doi: 10.1016/j.jacc.2016.08.053.