PMID- 27857871
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240326
IS  - 2193-6331 (Print)
IS  - 2193-634X (Electronic)
IS  - 2193-634X (Linking)
VI  - 77
IP  - 6
DP  - 2016 Dec
TI  - Sinonasal Carcinomas with Neuroendocrine Features: Histopathological 
      Differentiation and Treatment Outcomes.
PG  - 456-465
AB  - Objectives Sinonasal cancers with neuroendocrine features share similar clinical, 
      radiological, and histopathological features; however, these tumors often exhibit 
      varying degrees of aggressive behavior presenting significant treatment 
      challenges. The objective of this study was to report our experience with these 
      rare malignancies and to present a review of current literature. 
      Methods Following institutional review board approval, the records of all 
      patients with biopsy-proven sinonasal malignancies over a 5-year period were 
      reviewed. Results The study included 14 patients with olfactory neuroblastomas 
      (ONBs), 7 patients with sinonasal undifferentiated carcinomas (SNUC), and 2 
      patients with sinonasal neuroendocrine carcinomas (SNEC). Histopathologic markers 
      aided in final diagnosis, but showed variable specificity. In patients with 
      sufficient follow-up, the 2-year disease-free survival rate was 81% (9/11) for 
      ONB and 75% (3/4) for SNUC. Three patients developed a regional or distant 
      recurrence (two with ONBs and one with SNUC). Two patients, one with SNEC and one 
      with ONB, succumbed to brain radionecrosis related to proton radiation therapy. 
      Conclusions Overlapping clinical and histopathological features in poorly 
      differentiated sinonasal cancers with neuroendocrine features continue to present 
      a diagnostic challenge. Individualized assessment and treatment strategies can 
      improve the accuracy of the initial assessment and the treatment outcomes.
FAU - Soldatova, Liuba
AU  - Soldatova L
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Wexner Medical Center, Columbus, Ohio, United States.
FAU - Campbell, Raewyn G
AU  - Campbell RG
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Wexner Medical Center, Columbus, Ohio, United States.
FAU - Carrau, Ricardo L
AU  - Carrau RL
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Wexner Medical Center, Columbus, Ohio, United States; Department of Neurological 
      Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United 
      States.
FAU - Prevedello, Daniel M
AU  - Prevedello DM
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Wexner Medical Center, Columbus, Ohio, United States; Department of Neurological 
      Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United 
      States.
FAU - Wakely, Paul Jr
AU  - Wakely P Jr
AD  - Department of Pathology, The Ohio State University Wexner Medical Center, 
      Columbus, Ohio, United States.
FAU - Otto, Bradley A
AU  - Otto BA
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Wexner Medical Center, Columbus, Ohio, United States; Department of Neurological 
      Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United 
      States.
FAU - Filho, Leo F Ditzel
AU  - Filho LF
AD  - Department of Otolaryngology-Head and Neck Surgery, The Ohio State University 
      Wexner Medical Center, Columbus, Ohio, United States.
LA  - eng
PT  - Journal Article
DEP - 20160426
PL  - Germany
TA  - J Neurol Surg B Skull Base
JT  - Journal of neurological surgery. Part B, Skull base
JID - 101580780
PMC - PMC5112165
OTO - NOTNLM
OT  - esthesioneuroblastoma
OT  - olfactory neuroblastoma
OT  - sinonasal cancers of neuroectodermal origin
OT  - sinonasal cancers with neuroendocrine features
OT  - sinonasal carcinoid
OT  - sinonasal large cell cancer
OT  - sinonasal neuroendocrine carcinoma
OT  - sinonasal small cell cancer
OT  - sinonasal undifferentiated carcinoma
EDAT- 2016/11/20 06:00
MHDA- 2016/11/20 06:01
PMCR- 2017/12/01
CRDT- 2016/11/19 06:00
PHST- 2016/01/29 00:00 [received]
PHST- 2016/02/26 00:00 [accepted]
PHST- 2016/11/19 06:00 [entrez]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2016/11/20 06:01 [medline]
PHST- 2017/12/01 00:00 [pmc-release]
AID - 160018 [pii]
AID - 10.1055/s-0036-1582432 [doi]
PST - ppublish
SO  - J Neurol Surg B Skull Base. 2016 Dec;77(6):456-465. doi: 10.1055/s-0036-1582432. 
      Epub 2016 Apr 26.