PMID- 27858671
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20181113
IS  - 1878-5034 (Electronic)
IS  - 0006-355X (Print)
IS  - 0006-355X (Linking)
VI  - 53
IP  - 5-6
DP  - 2016
TI  - Effect of circulating tissue factor on hypercoagulability in type 2 diabetes 
      mellitus studied by rheometry and dielectric blood coagulometry.
PG  - 209-219
LID - 10.3233/BIR-16107 [doi]
AB  - BACKGROUND: Hypercoagulability in type 2 diabetes mellitus (T2DM) patients 
      increases their risk of cardiovascular diseases. OBJECTIVE: The aim of this work 
      was to investigate the hypercoagulation mechanism in T2DM patients in terms of 
      circulating tissue factor (TF). METHODS: Whole blood coagulation tests by damped 
      oscillation rheometry and dielectric blood coagulometry (DBCM) were performed. 
      RESULTS: The average coagulation time was significantly shorter for T2DM patients 
      than for healthy controls. In vitro addition of either anti-TF or anti-activated 
      factor VII (FVIIa) antibody to hypercoagulable blood samples prolonged 
      coagulation times for one group of patients, while coagulation times remained 
      short for another group. The levels of circulating TF were estimated in the 
      former group by measuring the coagulation times for blood samples from healthy 
      subjects with addition of various concentrations of TF and comparing them with 
      the coagulation times for the group. The results indicated that the levels of 
      circulating TF were on the order of subpicomolar at most. CONCLUSIONS: 
      Circulating TF is at least partially responsible for a hypercoagulable group of 
      T2DM patients, while an abnormality in the intrinsic coagulation pathway probably 
      occurs in the other group.
FAU - Uchimura, Isao
AU  - Uchimura I
AD  - Department of Endocrinology and Metabolism, Tokyo Medical and Dental University, 
      Tokyo, Japan.
FAU - Kaibara, Makoto
AU  - Kaibara M
AD  - RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan.
FAU - Nagasawa, Masayuki
AU  - Nagasawa M
AD  - Department of Pediatrics, Tokyo Medical and Dental University, Tokyo, Japan.
AD  - Department of Pediatrics, Musashino Red Cross Hospital, Musashino-city, Tokyo, 
      Japan.
FAU - Hayashi, Yoshihito
AU  - Hayashi Y
AD  - LE Development Department, R&D Division, Medical Business Unit, Imaging Products 
      & Solutions Sector, Sony Corporation, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biorheology
JT  - Biorheology
JID - 0372526
RN  - 9035-58-9 (Thromboplastin)
SB  - IM
MH  - Blood Coagulation
MH  - Blood Coagulation Tests/*methods
MH  - Diabetes Complications/*diagnosis/pathology
MH  - Diabetes Mellitus, Type 2/*diagnosis/pathology
MH  - Dielectric Spectroscopy/*methods
MH  - Humans
MH  - Thrombophilia/*complications
MH  - Thromboplastin/*metabolism
PMC - PMC5389046
OTO - NOTNLM
OT  - Dielectric spectroscopy
OT  - coagulation time
OT  - extrinsic/intrinsic coagulation pathway
OT  - hypercoagulable state
EDAT- 2016/11/20 06:00
MHDA- 2017/07/18 06:00
CRDT- 2016/11/19 06:00
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
PHST- 2016/11/19 06:00 [entrez]
AID - BIR16107 [pii]
AID - 10.3233/BIR-16107 [doi]
PST - ppublish
SO  - Biorheology. 2016;53(5-6):209-219. doi: 10.3233/BIR-16107.