PMID- 27858748
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240324
IS  - 2214-3599 (Print)
IS  - 2214-3602 (Electronic)
IS  - 2214-3599 (Linking)
VI  - 2
IP  - 4
DP  - 2015 Oct 7
TI  - The Impact of Pregnancy on Myotonic Dystrophy: A Registry-Based Study.
PG  - 447-452
AB  - BACKGROUND: The rate of symptom progression during pregnancy in myotonic 
      dystrophy (DM) is not currently known. Further, there is little data regarding 
      the rate of pregnancy complications and neonatal outcomes in DM. OBJECTIVE: This 
      study assesses symptom progression and complication rates during pregnancy in 
      women with DM. METHODS: DM women completed surveys regarding their prior 
      pregnancies. Participants identified complications during their pregnancies and 
      completed the Myotonic Dystrophy Health Index-Short Form (MDHI-SF) to measure 
      their disease burden and identify the severity of select symptoms six-months 
      prior to, during, and six-months after their first pregnancy. RESULTS: 152 women 
      with DM reported on 375 pregnancies. Among these pregnancies, there was a 32.5% 
      miscarriage rate. Some complications were common including: pre-term labor 
      (27.8%), pre-eclampsia (10.4%), and peripartum hemorrhage (13.9%). Participants' 
      perception of their mobility and ability to perform activities, as measured by 
      the MDHI-SF, worsened during pregnancy and did not recover during the post-partum 
      period. DISCUSSION: Miscarriage, maternal disease progression during pregnancy, 
      and other pregnancy related complications may occur in DM. Women with DM should 
      be counseled on these potential risks prior to considering pregnancy.
FAU - Johnson, Nicholas E
AU  - Johnson NE
AD  - Department of Neurology, The University of Utah, UT, USA.
FAU - Hung, Man
AU  - Hung M
AD  - Department of Orthopaedics, The University of Utah, UT, USA.
AD  - Division of Epidemiology, The University of Utah, UT, USA.
AD  - Division of Public Health, The University of Utah, UT, USA.
FAU - Nasser, Eriko
AU  - Nasser E
AD  - The Myotonic Dystrophy Foundation, CA, USA.
FAU - Hagerman, Katharine A
AU  - Hagerman KA
AD  - The Department of Neurology, Stanford University, CA, USA.
FAU - Chen, Wei
AU  - Chen W
AD  - Division of Epidemiology, The University of Utah, UT, USA.
FAU - Ciafaloni, Emma
AU  - Ciafaloni E
AD  - The Department of Neurology, University of Rochester, NY, USA.
FAU - Heatwole, Chad R
AU  - Heatwole CR
AD  - The Department of Neurology, University of Rochester, NY, USA.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Neuromuscul Dis
JT  - Journal of neuromuscular diseases
JID - 101649948
PMC - PMC5240614
OTO - NOTNLM
OT  - Myotonic dystrophy
OT  - neuromuscular disease
OT  - patient reported outcomes
OT  - pregnancy complications
EDAT- 2016/11/20 06:00
MHDA- 2016/11/20 06:01
PMCR- 2015/10/07
CRDT- 2016/11/19 06:00
PHST- 2016/11/19 06:00 [entrez]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2016/11/20 06:01 [medline]
PHST- 2015/10/07 00:00 [pmc-release]
AID - JND150095 [pii]
AID - 10.3233/JND-150095 [doi]
PST - ppublish
SO  - J Neuromuscul Dis. 2015 Oct 7;2(4):447-452. doi: 10.3233/JND-150095.