PMID- 27858854
OWN - NLM
STAT- MEDLINE
DCOM- 20170223
LR  - 20210109
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 44
DP  - 2016 Nov
TI  - Prevalence and associated factors of retinal vein occlusion in the Korean 
      National Health and Nutritional Examination Survey, 2008-2012: A cross-sectional 
      observational study.
PG  - e5185
LID - 10.1097/MD.0000000000005185 [doi]
LID - e5185
AB  - Retinal vein occlusion (RVO) is the second most common retinal vascular diseases 
      and there are only a few Asian population-based studies with small samples. 
      Hypertension is one of a modifiable risk factor of RVO, but no recent studies 
      have shown the relationship between RVO and hypertension control status. We aimed 
      to investigate the prevalence of RVO and its associated factors in an adult 
      Korean population.A nationwide population-based, cross-sectional study. We 
      enrolled 37,982 participants from the Korea National Health and Nutrition 
      Examination Survey who were 19 years or older and who had undergone 
      ophthalmologic exams from 2008 through 2012. All participants underwent a 
      comprehensive ophthalmic examination, standardized ophthalmic and health 
      interviews, and laboratory investigations. Digital fundus photographs were 
      interpreted by retinal specialists who investigated for the presence of RVO. The 
      prevalence of RVO was then estimated. RVO-associated factors were determined 
      using step-wise logistic regression analyses. We also performed a subgroup 
      analysis to evaluate the association between hypertension and RVO according to 
      hypertension control status and antihypertensive medication use.Of those enrolled 
      participants, 25,765 participants met our study criteria and were included in the 
      analyses. The overall RVO prevalence (n = 205) was 0.6 +/- 0.1% (0.6 +/- 0.1% for 
      branch RVO and <0.1% for central RVO), and no sex differences were observed. In 
      multivariate logistic regression analyses after adjusting for all potential risk 
      factors, we found the following factors to be significantly associated with RVO: 
      old age (odds ratio (OR) = 1.72, 95% CI: 1.27-2.34), hypertension (OR = 2.56, 95% 
      CI: 1.31-5.08), history of stroke (OR = 2.08, 95% CI: 1.01-4.45), and 
      hypercholesterolemia (OR = 1.84, 95% CI: 1.01-3.35). In a subset of participants 
      with hypertension, participants with uncontrolled hypertension (OR = 3.46, 95% 
      CI: 1.72-6.94) and unmedicated hypertension (OR = 4.12, 95% CI: 2.01-8.46) were 
      more significantly associated with RVO than participants without hypertension.RVO 
      prevalence in Korea was moderate relative to that in the rest of the world, and 
      RVO-associated factors were similar to those identified in other population-based 
      studies. Well-controlled hypertension and antihypertensive medication showed 
      inverse association with RVO.
FAU - Shin, Yong Un
AU  - Shin YU
AD  - Department of Ophthalmology, Hanyang University College of Medicine Department of 
      Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul Department of Ophthalmology, Kyungpook National University School 
      of Medicine, Daegu Biostatistical Consulting and Research Lab, Hanyang 
      University, Seoul, Korea.
FAU - Cho, Heeyoon
AU  - Cho H
FAU - Kim, Jong Min
AU  - Kim JM
FAU - Bae, Kunho
AU  - Bae K
FAU - Kang, Min Ho
AU  - Kang MH
FAU - Shin, Jae Pil
AU  - Shin JP
FAU - Nam, Eunwoo
AU  - Nam E
FAU - Kang, Se Woong
AU  - Kang SW
CN  - Epidemiologic Survey Committee of the Korean Ophthalmological Society
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypertension/complications
MH  - Male
MH  - Middle Aged
MH  - Nutrition Surveys
MH  - Prevalence
MH  - Republic of Korea
MH  - Retinal Vein Occlusion/complications/*epidemiology
MH  - Risk Factors
MH  - Young Adult
PMC - PMC5591102
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/11/20 06:00
MHDA- 2017/02/24 06:00
PMCR- 2016/11/04
CRDT- 2016/11/19 06:00
PHST- 2016/11/19 06:00 [entrez]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/02/24 06:00 [medline]
PHST- 2016/11/04 00:00 [pmc-release]
AID - 00005792-201611010-00019 [pii]
AID - 10.1097/MD.0000000000005185 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Nov;95(44):e5185. doi: 10.1097/MD.0000000000005185.