PMID- 27859422
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20210109
IS  - 1099-0844 (Electronic)
IS  - 0263-6484 (Print)
IS  - 0263-6484 (Linking)
VI  - 34
IP  - 8
DP  - 2016 Dec
TI  - Follistatin-like protein 1 contributes to dendritic cell and T-lymphocyte 
      activation in nasopharyngeal carcinoma patients by altering nuclear factor kappab and 
      Jun N-terminal kinase expression.
PG  - 554-562
LID - 10.1002/cbf.3227 [doi]
AB  - Follistatin-like protein 1 (FSTL1) is a newly characterized protein that can 
      regulate the immune response in various ways. Dendritic cells (DCs) are central 
      to immune regulation. In this study, we explored the impact of FSTL1 on DC 
      activity in nasopharyngeal carcinoma (NPC) patients. The surface expression of 
      CD40, CD86, and HLA-DR on DCs was analyzed and showed significantly elevated 
      expression levels, indicating DC maturity. After FSTL1 was added to DCs collected 
      from NPC patients (n = 50), controls (n = 47), and healthy donors (n = 10), 
      interferon gamma secretion and T-cell receptor expression in cytotoxic T lymphocytes 
      were also investigated. In the experimental groups, the expression of the 
      critical immune protein nuclear factor (NF)-kappab was upregulated, whereas Jun 
      N-terminal kinase (JNK) was downregulated. Our findings demonstrate that FSTL1 
      plays a critical role in immune regulation, enhancing the antigen presentation 
      ability of DCs by up-regulating NF-kappab expression and down-regulating JNK 
      expression.
CI  - Copyright (c) 2016 The Authors Cell Biochemistry and Function published by John 
      Wiley & Sons Ltd.
FAU - Wang, Hong
AU  - Wang H
AD  - Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated 
      Hospital of Guangxi Medical University, Nanning, Guangxi, China.
FAU - Wu, Senyong
AU  - Wu S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital, 
      Guigang, Guangxi, China.
FAU - Huang, Shiping
AU  - Huang S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital, 
      Guigang, Guangxi, China.
FAU - Yin, Shaolin
AU  - Yin S
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital, 
      Guigang, Guangxi, China.
AD  - Department of Otolaryngology, The Cooperation of Chinese and Western Medicine 
      Hospital in Guangzhou, Guangzhou, China.
FAU - Zou, Guilong
AU  - Zou G
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital, 
      Guigang, Guangxi, China.
AD  - Department of Otolaryngology, The People's Hospital of Hezhou, Guangxi, China.
FAU - Huang, Kuan'en
AU  - Huang K
AD  - Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated 
      Hospital of Guangxi Medical University, Nanning, Guangxi, China.
AD  - Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital, 
      Guigang, Guangxi, China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated 
      Hospital of Guangxi Medical University, Nanning, Guangxi, China.
AD  - Department of Otolaryngology, The Cooperation of Chinese and Western Medicine 
      Hospital in Guangzhou, Guangzhou, China.
FAU - Tang, Anzhou
AU  - Tang A
AD  - Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated 
      Hospital of Guangxi Medical University, Nanning, Guangxi, China.
FAU - Wen, Wensheng
AU  - Wen W
AD  - Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated 
      Hospital of Guangxi Medical University, Nanning, Guangxi, China.
LA  - eng
PT  - Journal Article
DEP - 20161116
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Follistatin-Related Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 158709-61-6 (FSTL1 protein, human)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Adult
MH  - Blotting, Western
MH  - Carcinoma
MH  - Cells, Cultured
MH  - Dendritic Cells/*metabolism
MH  - Female
MH  - Follistatin-Related Proteins/*metabolism
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - JNK Mitogen-Activated Protein Kinases/*metabolism
MH  - *Lymphocyte Activation
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - NF-kappa B/*metabolism
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*immunology
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, Antigen, T-Cell/metabolism
MH  - T-Lymphocytes/*metabolism
PMC - PMC5215428
OTO - NOTNLM
OT  - Jun N-terminal kinase
OT  - T lymphocyte
OT  - dendritic cell
OT  - follistatin-like protein 1
OT  - nasopharyngeal carcinoma
OT  - nuclear factor kappab
EDAT- 2016/11/20 06:00
MHDA- 2017/02/01 06:00
PMCR- 2017/01/05
CRDT- 2016/11/19 06:00
PHST- 2016/07/06 00:00 [received]
PHST- 2016/09/01 00:00 [revised]
PHST- 2016/09/14 00:00 [accepted]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
PHST- 2016/11/19 06:00 [entrez]
PHST- 2017/01/05 00:00 [pmc-release]
AID - CBF3227 [pii]
AID - 10.1002/cbf.3227 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 2016 Dec;34(8):554-562. doi: 10.1002/cbf.3227. Epub 2016 Nov 
      16.