PMID- 27859804
OWN - NLM
STAT- MEDLINE
DCOM- 20180404
LR  - 20180412
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
VI  - 29
IP  - 3
DP  - 2017 May
TI  - Gastric mucosal cracked and cobblestone-like changes resulting from proton pump 
      inhibitor use.
PG  - 307-313
LID - 10.1111/den.12765 [doi]
AB  - BACKGROUND AND AIM: Use of proton pump inhibitors (PPI) is histologically 
      associated with oxyntic gland dilatations. Two interesting mucosal changes are 
      often detected endoscopically in patients who use PPI: gastric cracked mucosa 
      (GCM) and gastric cobblestone-like mucosa (GCSM). The aim of the present study 
      was to clarify the relationship between PPI use and these mucosal changes. 
      METHODS: This was a single-center observational study. All successive subjects 
      who underwent a routine esophagogastroduodenoscopy (EGD) between August and 
      November 2014 in Hokkaido University Hospital were enrolled. Endoscopists carried 
      out the assessment blinded to the use of PPI and checked for GCSM and GCM using 
      original diagnostic criteria for GCM and GCSM. Subjects were divided into two 
      groups: those who used PPI (PPI group) and those who did not (control group). 
      Endoscopic findings and backgrounds were compared between the two groups. 
      RESULTS: A total of 538 patients were analyzed (control group: 374 patients, 
      men/women: 204/170, median age: 65.2 years; PPI group: 164 patients, men/women: 
      89/75, median age: 67.1 years). GCM was detected in 54 (10.0%) subjects, and GCSM 
      was detected in 18 (3.3%) subjects. There was a significant difference in the 
      prevalence rate of GCM between the control group (14/374, 3.7%) and the PPI group 
      (40/164, 24.4%) (P < 0.01). GCSM was significantly more prevalent in the PPI 
      group (15/164, 9.1%) than in the control group (3/374, 0.8%) (P < 0.01). 
      CONCLUSION: Novel GCM and GCSM endoscopic findings in the corpus area seem to be 
      strongly associated with PPI use.
CI  - (c) 2016 Japan Gastroenterological Endoscopy Society.
FAU - Miyamoto, Shuichi
AU  - Miyamoto S
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Kato, Mototsugu
AU  - Kato M
AD  - National Hospital Organization Hakodate Hospital, Hakodate, Japan.
FAU - Tsuda, Momoko
AU  - Tsuda M
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Matsuda, Kana
AU  - Matsuda K
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Muranaka, Tetsuhito
AU  - Muranaka T
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Abiko, Satoshi
AU  - Abiko S
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Ono, Masayoshi
AU  - Ono M
AD  - Hakodate Municipal Hospital, Hakodate, Japan.
FAU - Mizushima, Takeshi
AU  - Mizushima T
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Omori, Saori
AU  - Omori S
AD  - Iwamizawa Municipal General Hospital, Iwamizawa, Japan.
FAU - Yamamoto, Keiko
AU  - Yamamoto K
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Mabe, Katsuhiro
AU  - Mabe K
AD  - National Hospital Organization Hakodate Hospital, Hakodate, Japan.
FAU - Ono, Shoko
AU  - Ono S
AD  - Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan.
FAU - Kudo, Takahiko
AU  - Kudo T
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
FAU - Shimizu, Yuichi
AU  - Shimizu Y
AD  - Division of Endoscopy, Hokkaido University Hospital, Sapporo, Japan.
FAU - Sakamoto, Naoya
AU  - Sakamoto N
AD  - Department of Gastroenterology and Hepatology, Hokkaido University Graduate 
      School of Medicine, Sapporo, Japan.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170122
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
CIN - Dig Endosc. 2017 May;29(3):294-296. PMID: 28199735
MH  - Aged
MH  - Biopsy
MH  - Dilatation, Pathologic
MH  - Endoscopy, Digestive System
MH  - Female
MH  - Gastric Mucosa/*drug effects/pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parietal Cells, Gastric/drug effects/pathology
MH  - Proton Pump Inhibitors/*adverse effects
MH  - Retrospective Studies
MH  - Stomach Diseases/*drug therapy/pathology
OTO - NOTNLM
OT  - gastric cobblestone-like mucosa
OT  - gastric cracked mucosa
OT  - helicobacter pylori
OT  - parietal cell
OT  - proton pump inhibitor
EDAT- 2016/11/20 06:00
MHDA- 2018/04/05 06:00
CRDT- 2016/11/19 06:00
PHST- 2016/09/21 00:00 [received]
PHST- 2016/11/14 00:00 [accepted]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2018/04/05 06:00 [medline]
PHST- 2016/11/19 06:00 [entrez]
AID - 10.1111/den.12765 [doi]
PST - ppublish
SO  - Dig Endosc. 2017 May;29(3):307-313. doi: 10.1111/den.12765. Epub 2017 Jan 22.