PMID- 27859947
OWN - NLM
STAT- MEDLINE
DCOM- 20171004
LR  - 20220409
IS  - 1099-1557 (Electronic)
IS  - 1053-8569 (Print)
IS  - 1053-8569 (Linking)
VI  - 26
IP  - 1
DP  - 2017 Jan
TI  - Long-term use of proton pump inhibitors and prevalence of disease- and 
      drug-related reasons for gastroprotection-a cross-sectional population-based 
      study.
PG  - 9-16
LID - 10.1002/pds.4135 [doi]
AB  - PURPOSE: To analyse the prevalence of long-term use of proton pump inhibitors 
      (PPI) with respect to underlying diseases and drugs, and to find predictors for 
      such treatment when an evident rationale for the PPI treatment is lacking. 
      METHODS: The study cohort consisted of individuals, >/=65 years in 2010, residing 
      in the Region Vastra Gotaland during 2005-2010. For individuals with and without 
      long-term use of PPI in 2010, we investigated the prevalence of an underlying 
      diagnosis, that is, an acid-related disease during the five preceding years, as 
      well as concomitant long-term use of antiplatelet agents or cyclooxygenase 
      inhibitors. RESULTS: In all, 278 205 individuals (median age: 74 years; 55% 
      female; median 3 drugs per person; 5% nursing home residents, 11% with multi-dose 
      drug dispensing) were included in the analyses, 32 421 (12%) of whom were on 
      long-term treatment with PPI in 2010. For 12 253 individuals (38%) with such 
      treatment, no underlying rationale was found. In individuals without a disease- 
      or a drug-related reason for PPI use, nursing home residence, number of drugs, 
      female sex, but not multi-dose drug dispensing, were associated with long-term 
      use of PPI; adjusted odds ratios (95% confidence interval): 1.63 (1.49; 1.78), 
      1.27 (1.26; 1.28), 1.24 (1.19; 1.29), and 0.94 (0.88; 1.01), respectively. 
      CONCLUSIONS: Long-term use of PPI occurs in one out of nine individuals in the 
      older population. For four out of ten of these, no reason for PPI use can be 
      identified. Nursing home residence, female sex, and greater number of drugs 
      predict non-rational long-term use of PPI. (c) 2016 The Authors. 
      Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.
CI  - (c) 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley 
      & Sons Ltd.
FAU - Wallerstedt, Susanna M
AU  - Wallerstedt SM
AD  - Department of Pharmacology, Sahlgrenska Academy, University of Gothenburg, 
      Sweden.
AD  - Department of Clinical Pharmacology, Sahlgrenska University Hospital, Sweden.
FAU - Fastbom, Johan
AU  - Fastbom J
AD  - Aging Research Center, Karolinska Institutet and Stockholm University, Sweden.
FAU - Linke, Johannes
AU  - Linke J
AD  - Department of Geriatrics and Internal Medicine, Sodertalje Hospital, Sodertalje, 
      Sweden.
FAU - Vitols, Sigurd
AU  - Vitols S
AD  - Department of Medicine, Clinical Pharmacology Unit, Karolinska Institutet, 
      Stockholm, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161116
PL  - England
TA  - Pharmacoepidemiol Drug Saf
JT  - Pharmacoepidemiology and drug safety
JID - 9208369
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Gastrointestinal Diseases/*drug therapy
MH  - Homes for the Aged/statistics & numerical data
MH  - Humans
MH  - Inappropriate Prescribing/*statistics & numerical data
MH  - Male
MH  - Nursing Homes/statistics & numerical data
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Prevalence
MH  - Proton Pump Inhibitors/administration & dosage/*therapeutic use
MH  - Sex Factors
MH  - Time Factors
PMC - PMC5248645
OTO - NOTNLM
OT  - overuse
OT  - pharmacoepidemiology
OT  - proton pump inhibitor
EDAT- 2016/11/20 06:00
MHDA- 2017/10/05 06:00
PMCR- 2017/01/20
CRDT- 2016/11/19 06:00
PHST- 2016/06/28 00:00 [received]
PHST- 2016/10/04 00:00 [revised]
PHST- 2016/10/18 00:00 [accepted]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/10/05 06:00 [medline]
PHST- 2016/11/19 06:00 [entrez]
PHST- 2017/01/20 00:00 [pmc-release]
AID - PDS4135 [pii]
AID - 10.1002/pds.4135 [doi]
PST - ppublish
SO  - Pharmacoepidemiol Drug Saf. 2017 Jan;26(1):9-16. doi: 10.1002/pds.4135. Epub 2016 
      Nov 16.