PMID- 27861154
OWN - NLM
STAT- MEDLINE
DCOM- 20180220
LR  - 20181113
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 7
IP  - 48
DP  - 2016 Nov 29
TI  - Presence of lacunar infarctions is associated with the spatial navigation 
      impairment in patients with mild cognitive impairment: a DTI study.
PG  - 78310-78319
LID - 10.18632/oncotarget.13409 [doi]
AB  - Lacunar cerebral infarction (LI) is one of risk factors of vascular dementia and 
      correlates with progression of cognitive impairment including the executive 
      functions. However, little is known on spatial navigation impairment and its 
      underlying microstructural alteration of white matter in patients with LI and 
      with or without mild cognitive impairment (MCI). Our aim was to investigate 
      whether the spatial navigation impairment correlated with the white matter 
      integrity in LI patients with MCI (LI-MCI). Thirty patients with LI were included 
      in the study and were divided into LI-MCI (n=17) and non MCI (LI-Non MCI) groups 
      (n=13) according neuropsychological tests.The microstructural integrity of white 
      matter was assessed by calculating a fractional anisotropy (FA) and mean 
      diffusivity (MD) from diffusion tensor imaging (DTI) scans. The spatial 
      navigation accuracy, separately evaluated as egocentric and allocentric, was 
      assessed by a computerized human analogue of the Morris Water Maze tests Amunet. 
      LI-MCI performed worse than the CN and LI-NonMCI groups on egocentric and delayed 
      spatial navigation subtests. LI-MCI patients have spatial navigation deficits. 
      The microstructural abnormalities in diffuse brain regions, including 
      hippocampus, uncinate fasciculus and other brain regions may contribute to the 
      spatial navigation impairment in LI-MCI patients at follow-up.
FAU - Wu, Yan-Feng
AU  - Wu YF
AD  - Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
AD  - Department of Neurology, The Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
FAU - Wu, Wen-Bo
AU  - Wu WB
AD  - Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
FAU - Liu, Qing-Ping
AU  - Liu QP
AD  - Department of Neurology, The Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
FAU - He, Wen-Wen
AU  - He WW
AD  - Department of Radiology, The Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
FAU - Ding, Hong
AU  - Ding H
AD  - Department of Neurology, The Second Affiliated Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
FAU - Nedelska, Zuzana
AU  - Nedelska Z
AD  - Department of Neurology, Memory Disorders Clinic, Charles University in Prague, 
      2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
FAU - Hort, Jakub
AU  - Hort J
AD  - Department of Neurology, Memory Disorders Clinic, Charles University in Prague, 
      2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic.
FAU - Zhang, Bing
AU  - Zhang B
AD  - Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University 
      Medical School, Nanjing, Jiangsu, P. R. China.
FAU - Xu, Yun
AU  - Xu Y
AD  - Department of Neurology, The Affiliated Drum Tower Hospital of Nanjing Medical 
      University, Nanjing, Jiangsu, P. R. China.
AD  - Jiangsu Key Laboratory for Molecular Medicine, Nanjing University Medical School, 
      Nanjing, China.
AD  - Nanjing Medical Research Center on Neurology and Psychiatry, Jiangsu, P. R. 
      China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
SB  - IM
MH  - Aged
MH  - Anisotropy
MH  - Case-Control Studies
MH  - *Cognition
MH  - Cognitive Dysfunction/*diagnostic imaging/physiopathology/psychology
MH  - *Diffusion Magnetic Resonance Imaging
MH  - *Diffusion Tensor Imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - *Space Perception
MH  - *Spatial Behavior
MH  - Stroke, Lacunar/*diagnostic imaging/physiopathology/psychology
MH  - White Matter/*diagnostic imaging/physiopathology
PMC - PMC5346640
OTO - NOTNLM
OT  - Gerotarget
OT  - diffusion tensor imaging
OT  - lacunar infarction
OT  - mild cognitive impairment
OT  - spatial navigation
COIS- CONFLICTS OF INTEREST The authors declare no conflict of interest.
EDAT- 2016/11/20 06:00
MHDA- 2018/02/21 06:00
PMCR- 2016/11/29
CRDT- 2016/11/19 06:00
PHST- 2016/08/02 00:00 [received]
PHST- 2016/11/06 00:00 [accepted]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2018/02/21 06:00 [medline]
PHST- 2016/11/19 06:00 [entrez]
PHST- 2016/11/29 00:00 [pmc-release]
AID - 13409 [pii]
AID - 10.18632/oncotarget.13409 [doi]
PST - ppublish
SO  - Oncotarget. 2016 Nov 29;7(48):78310-78319. doi: 10.18632/oncotarget.13409.