PMID- 27861567
OWN - NLM
STAT- MEDLINE
DCOM- 20170626
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 11
IP  - 11
DP  - 2016
TI  - Age-Related Cataract Is Associated with Elevated Serum Immunoglobulin E Levels in 
      the South Korean Population: A Cross-Sectional Study.
PG  - e0166331
LID - 10.1371/journal.pone.0166331 [doi]
LID - e0166331
AB  - BACKGROUND: Previous research has suggested that immunoglobulin E (IgE)-mediated 
      events lead to several chronic diseases. We investigated the association between 
      allergic conditions and age-related cataracts in the South Korean adult 
      population. METHODS: A cross-sectional study was performed using data obtained 
      from 1,170 participants aged 40 years or older who were enrolled in the Korean 
      National Health and Nutrition Examination Survey 2010. Multivariable logistic 
      regression was used to examine the relationship between age-related cataracts and 
      allergic conditions, including total serum IgE and allergen-specific serum IgE 
      levels, after adjustment for potential confounders (age, sex, alcohol 
      consumption, smoking, sun exposure, blood pressure, plasma glucose and 
      cholesterol levels, as well as histories of asthma, atopic dermatitis, and 
      rheumatoid arthritis). RESULTS: After adjusting for potential confounders, the 
      odds ratio (OR) for age-related cataract was greater in participants with higher 
      total serum IgE levels (OR = 1.37; P = 0.044). In particular, increased IgE 
      levels were significantly associated with nuclear cataract (OR = 1.42; P = 
      0.032). However, allergen-specific serum IgE levels did not differ significantly 
      between groups. In the trend analysis, no significant relationship was observed 
      between serum IgE and any type of age-related cataract. CONCLUSION: Increased 
      total serum IgE level is independently associated with age-related cataracts 
      after adjustment for confounding factors.
FAU - Yoo, Tae Keun
AU  - Yoo TK
AD  - Institute of Vision Research, Department of Ophthalmology, Yonsei University 
      College of Medicine, Seoul, South Korea.
FAU - Kim, Sun Woong
AU  - Kim SW
AD  - Department of Ophthalmology, Yonsei University Wonju College of Medicine, Wonju, 
      South Korea.
FAU - Seo, Kyoung Yul
AU  - Seo KY
AD  - Institute of Vision Research, Department of Ophthalmology, Yonsei University 
      College of Medicine, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20161118
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Biomarkers
MH  - Cataract/*blood/epidemiology/*etiology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood/immunology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - Population Surveillance
MH  - Prevalence
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Socioeconomic Factors
PMC - PMC5115736
COIS- The authors have declared that no competing interests exist.
EDAT- 2016/11/20 06:00
MHDA- 2017/06/27 06:00
PMCR- 2016/11/18
CRDT- 2016/11/19 06:00
PHST- 2016/07/30 00:00 [received]
PHST- 2016/10/26 00:00 [accepted]
PHST- 2016/11/19 06:00 [entrez]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/06/27 06:00 [medline]
PHST- 2016/11/18 00:00 [pmc-release]
AID - PONE-D-16-30541 [pii]
AID - 10.1371/journal.pone.0166331 [doi]
PST - epublish
SO  - PLoS One. 2016 Nov 18;11(11):e0166331. doi: 10.1371/journal.pone.0166331. 
      eCollection 2016.