PMID- 27862163
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20210109
IS  - 1440-1681 (Electronic)
IS  - 0305-1870 (Print)
IS  - 0305-1870 (Linking)
VI  - 44
IP  - 2
DP  - 2017 Feb
TI  - Effects of high-sodium intake on systemic blood pressure and vascular responses 
      in spontaneously diabetic WBN/Kob-Lepr(fa/fa) rats.
PG  - 305-312
LID - 10.1111/1440-1681.12700 [doi]
AB  - The prevalence of type 2 diabetes mellitus (T2DM) and hypertension has markedly 
      increased worldwide. The purpose of the present study was to examine the effects 
      of a high-salt intake on the systolic blood pressure (SBP) and vascular responses 
      in WBN/Kob-Lepr(fa/fa) (WBKDF) rats, a new spontaneous animal model of T2DM. Male 
      WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into 
      two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 
      8%) diet for 14 weeks: (i) Wistar rats on NS diet (Wistar-NS); (ii) Wistar rats 
      on HS diet (Wistar-HS); (iii) WBKDF rats on NS diet (WBKDF-NS); (iv) WBKDF rats 
      on HS diets (WBKDF-HS). Neither WBKDF-NS nor Wistar-NS rats showed significant 
      changes in SBP throughout the experiment, but both WBKDF-HS and Wistar-HS 
      exhibited significant elevation of SBP, which was more prominent (P<.01) in 
      WBKDF-HS than in Wistar-HS. Phenylephrine-induced contractions of isolated 
      thoracic aortic rings were significantly (P<.01) enhanced in WBKDF-HS and 
      Wistar-HS compared with the respective strain of rats on the NS diet. In 
      contrast, acetylcholine- and nitroprusside-induced relaxation were significantly 
      (P<.01) diminished in both WBKDF-HS and Wistar-HS, and these HS diet-induced 
      changes were more profound (P<.01) in WBKDF rats than in Wistar rats. 
      Significantly (P<.05) higher plasma concentrations of 8-iso-prostaglandin F(2alpha) 
      and sodium ions were observed in WBKDF-HS than in Wistar-HS. The current study 
      demonstrated that WBKDF-HS rats developed salt-sensitive hypertension associated 
      with vascular dysfunction. The WBKDF rat may be a useful model for investigating 
      the etiology of hypertension with T2DM.
CI  - (c) 2016 The Authors. Clinical and Experimental Pharmacology and Physiology 
      Published by John Wiley & Sons Australia, Ltd.
FAU - Takagi, Yoshiichi
AU  - Takagi Y
AD  - Laboratory of Veterinary Pharmacology, Azabu University, Sagamihara, Kanagawa, 
      Japan.
FAU - Kadowaki, Haruno
AU  - Kadowaki H
AD  - Laboratory of Veterinary Pharmacology, Azabu University, Sagamihara, Kanagawa, 
      Japan.
FAU - Kobayashi, Ikumi
AU  - Kobayashi I
AD  - Laboratory of Veterinary Pharmacology, Azabu University, Sagamihara, Kanagawa, 
      Japan.
FAU - Ito, Kaoru
AU  - Ito K
AD  - Clinical Nutrition, Chiba University Hospital, Chiba, Japan.
FAU - Ito, Katsuaki
AU  - Ito K
AD  - Laboratory of Veterinary Pharmacology, Azabu University, Sagamihara, Kanagawa, 
      Japan.
FAU - Shirai, Mitsuyuki
AU  - Shirai M
AD  - Laboratory of Veterinary Pharmacology, Azabu University, Sagamihara, Kanagawa, 
      Japan.
FAU - Asai, Fumitoshi
AU  - Asai F
AD  - Laboratory of Veterinary Pharmacology, Azabu University, Sagamihara, Kanagawa, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Clin Exp Pharmacol Physiol
JT  - Clinical and experimental pharmacology & physiology
JID - 0425076
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Sodium Chloride, Dietary)
SB  - IM
MH  - Animals
MH  - Animals, Congenic
MH  - Aorta, Thoracic/drug effects/physiopathology
MH  - Blood Glucose/analysis
MH  - Blood Pressure/*drug effects
MH  - Diabetes Mellitus, Experimental/blood/complications/*physiopathology
MH  - Diabetes Mellitus, Type 2/blood/complications/*physiopathology
MH  - Hypertension/etiology
MH  - Insulin/blood
MH  - Kidney/pathology/physiopathology
MH  - Male
MH  - Obesity/blood/complications/*physiopathology
MH  - Rats, Wistar
MH  - Sodium Chloride, Dietary/*adverse effects
MH  - Vasoconstriction/*drug effects
PMC - PMC5299487
OTO - NOTNLM
OT  - WBN/Kob-Leprfa/fa rat
OT  - high-sodium diet
OT  - salt-sensitive hypertension
OT  - type 2 diabetes mellitus
EDAT- 2016/11/20 06:00
MHDA- 2017/09/14 06:00
PMCR- 2017/02/09
CRDT- 2016/11/19 06:00
PHST- 2016/05/18 00:00 [received]
PHST- 2016/11/10 00:00 [revised]
PHST- 2016/11/10 00:00 [accepted]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
PHST- 2016/11/19 06:00 [entrez]
PHST- 2017/02/09 00:00 [pmc-release]
AID - CEP12700 [pii]
AID - 10.1111/1440-1681.12700 [doi]
PST - ppublish
SO  - Clin Exp Pharmacol Physiol. 2017 Feb;44(2):305-312. doi: 10.1111/1440-1681.12700.