PMID- 2786362
OWN - NLM
STAT- MEDLINE
DCOM- 19890712
LR  - 20061115
IS  - 0003-0805 (Print)
IS  - 0003-0805 (Linking)
VI  - 139
IP  - 6
DP  - 1989 Jun
TI  - Pressure-volume curves in smokers. Comparison with alpha-1-antitrypsin 
      deficiency.
PG  - 1452-8
AB  - The diagnosis of emphysema has been associated with changes in the appearance of 
      the pressure-volume (P-V) curve: reduced maximal recoil pressure, increased lung 
      volume, and a shift in the position of the curve to the left. In our clinical 
      practice, we have observed that patients with chronic obstructive lung disease 
      (COPD) commonly had P-V curves with reduced maximal elastic recoil that are 
      difficult to classify according to the classic description of the P-V curve in 
      emphysema. In order to study the variability of P-V curves, we studied 39 
      cigarette smokers attending a pulmonary clinic (age, 61 +/- 1 yr; smoking 
      history, 45 +/- 3 pack-years; mean +/- SEM) and compared them with 20 patients 
      with alpha-1-antitrypsin deficiency (AATD) (age, 41 +/- 2 yr; 13 smokers with a 
      smoking history of 17 +/- 2 pack-years, and seven nonsmokers). Subjects underwent 
      spirometry, lung volume, and diffusing capacity measurements as well as static 
      deflation P-V curves. To characterize the P-V curves, we used transpulmonary 
      pressure at 90% of TLC (PL90) as a measure of overall recoil and specific 
      compliance (Csp) as a measure of the slope of the initial part of the P-V curve. 
      The curves of non-AATD smokers were classified into three groups: 13 had PL90 
      greater than or equal to 80% predicted (Group I), 13 had PL90 less than 80% 
      predicted and Csp greater than or equal to 0.08 (Group II), and 13 had PL90 less 
      than 80% predicted and Csp less than 0.08 (Group III).(ABSTRACT TRUNCATED AT 250 
      WORDS)
FAU - Eidelman, D H
AU  - Eidelman DH
AD  - Desmond Stoker Laboratories, Royal Victoria Hospital, Montreal, Quebec, Canada.
FAU - Ghezzo, H
AU  - Ghezzo H
FAU - Kim, W D
AU  - Kim WD
FAU - Hyatt, R E
AU  - Hyatt RE
FAU - Cosio, M G
AU  - Cosio MG
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Rev Respir Dis
JT  - The American review of respiratory disease
JID - 0370523
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Forced Expiratory Volume
MH  - Functional Residual Capacity
MH  - Humans
MH  - *Lung Volume Measurements
MH  - Male
MH  - Middle Aged
MH  - Pressure
MH  - Pulmonary Ventilation
MH  - Smoking/*physiopathology
MH  - Total Lung Capacity
MH  - Vital Capacity
MH  - *alpha 1-Antitrypsin Deficiency
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 10.1164/ajrccm/139.6.1452 [doi]
PST - ppublish
SO  - Am Rev Respir Dis. 1989 Jun;139(6):1452-8. doi: 10.1164/ajrccm/139.6.1452.