PMID- 27864283
OWN - NLM
STAT- MEDLINE
DCOM- 20170130
LR  - 20170130
IS  - 1745-7270 (Electronic)
IS  - 1672-9145 (Linking)
VI  - 49
IP  - 1
DP  - 2017 Jan
TI  - Tumor necrosis factor-alpha: a key contributor to intervertebral disc degeneration.
PG  - 1-13
LID - 10.1093/abbs/gmw112 [doi]
AB  - Intervertebral disc (IVD) degeneration (IDD) is the most common cause leading to 
      low back pain (LBP), which is a highly prevalent, costly, and crippling condition 
      worldwide. Current treatments for IDD are limited to treat the symptoms and do 
      not target the pathophysiology. Tumor necrosis factor-alpha (TNF-alpha) is one of the 
      most potent pro-inflammatory cytokines and signals through its receptors TNFR1 
      and TNFR2. TNF-alpha is highly expressed in degenerative IVD tissues, and it is 
      deeply involved in multiple pathological processes of disc degeneration, 
      including matrix destruction, inflammatory responses, apoptosis, autophagy, and 
      cell proliferation. Importantly, anti-TNF-alpha therapy has shown promise for 
      mitigating disc degeneration and relieving LBP. In this review, following a brief 
      description of TNF-alpha signal transduction, we mainly focus on the expression 
      pattern and roles of TNF-alpha in IDD, and summarize the emerging progress regarding 
      its inhibition as a promising biological therapeutic approach to disc 
      degeneration and associated LBP. A better understanding will help to develop 
      novel TNF-alpha-centered therapeutic interventions for degenerative disc disease.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the 
      Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological 
      Sciences, Chinese Academy of Sciences. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Wang, Cheng
AU  - Wang C
AD  - Department of Spine Surgery, The First Affiliated Hospital, University of South 
      China, Hengyang 421001, China.
FAU - Yu, Xiaohua
AU  - Yu X
AD  - Medical Research Center, University of South China, Hengyang 421001, China.
FAU - Yan, Yiguo
AU  - Yan Y
AD  - Department of Spine Surgery, The First Affiliated Hospital, University of South 
      China, Hengyang 421001, China.
FAU - Yang, Wei
AU  - Yang W
AD  - Department of Hand and Micro-surgery, The First Affiliated Hospital, University 
      of South China, Hengyang 421001, China.
FAU - Zhang, Shujun
AU  - Zhang S
AD  - Department of Spine Surgery, The First Affiliated Hospital, University of South 
      China, Hengyang 421001, China.
FAU - Xiang, Yongxiao
AU  - Xiang Y
AD  - Department of Hand and Micro-surgery, The First Affiliated Hospital, University 
      of South China, Hengyang 421001, China.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Hand and Micro-surgery, The First Affiliated Hospital, University 
      of South China, Hengyang 421001, China.
FAU - Wang, Wenjun
AU  - Wang W
AD  - Department of Spine Surgery, The First Affiliated Hospital, University of South 
      China, Hengyang 421001, China wwwwjj167@qq.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161117
PL  - China
TA  - Acta Biochim Biophys Sin (Shanghai)
JT  - Acta biochimica et biophysica Sinica
JID - 101206716
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Humans
MH  - Intervertebral Disc Degeneration/*physiopathology
MH  - Protein Conformation
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/chemistry/*physiology
OTO - NOTNLM
OT  - ECM
OT  - IDD
OT  - TNF-alpha
OT  - TNFR1
OT  - TNFR2
EDAT- 2016/11/20 06:00
MHDA- 2017/01/31 06:00
CRDT- 2016/11/20 06:00
PHST- 2016/07/05 00:00 [received]
PHST- 2016/10/13 00:00 [revised]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/01/31 06:00 [medline]
PHST- 2016/11/20 06:00 [entrez]
AID - gmw112 [pii]
AID - 10.1093/abbs/gmw112 [doi]
PST - ppublish
SO  - Acta Biochim Biophys Sin (Shanghai). 2017 Jan;49(1):1-13. doi: 
      10.1093/abbs/gmw112. Epub 2016 Nov 17.