PMID- 27864670
OWN - NLM
STAT- MEDLINE
DCOM- 20171226
LR  - 20181202
IS  - 1708-0428 (Electronic)
IS  - 0960-8923 (Linking)
VI  - 27
IP  - 5
DP  - 2017 May
TI  - Relationship Between Vitamin D Deficiency and the Components of Metabolic 
      Syndrome in Patients with Morbid Obesity, Before and 1 Year After Laparoscopic 
      Roux-en-Y Gastric Bypass or Sleeve Gastrectomy.
PG  - 1222-1228
LID - 10.1007/s11695-016-2445-0 [doi]
AB  - BACKGROUND: Vitamin D deficiency (VDD) is associated with obesity and metabolic 
      syndrome (MS). After bariatric surgery (BS), high rates of VDD often persist and 
      some patients are refractory to the resolution of comorbidities. The aim of the 
      present study is to analyse the relationship between the levels of vitamin D and 
      the persistence of MS components at 12 months after BS, according to the surgical 
      technique used. METHODS: We performed a retrospective study of 46 patients 
      undergoing BS: 23 underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP) and 23 
      laparoscopic sleeve gastrectomy (LSG). These patients had an average BMI of 
      45 kg/m(2) (34-63). Levels of vitamin D were classified as deficient (<20 ng/dl), 
      insufficient (20-30 ng/dl) or normal (>30 ng/dl) and analysed in relation to the 
      components of MS (high blood pressure (HBP), dyslipidaemia (DL) and type 2 
      diabetes mellitus (T2DM) preoperatively and 12 months after surgery. RESULTS: VDD 
      was observed in 77% of the patients prior to surgery. There were no significant 
      associations between predisposing factors and baseline vitamin D. After surgery, 
      plasma levels of vitamin D increased in both groups, but only 18% of the patients 
      achieved normal values. Both groups had achieved significant improvements in MS 
      components. Thus, 63% of all the patients achieved complete resolution of HBP, 
      54% that of DL and 77% that of T2DM. Moreover, MS was present in 11% of the 
      patients, compared to 63% at baseline, and the MS resolution rate was 83%, with 
      no significant differences between LRYGBP and LSG. CONCLUSIONS: There is a 
      relationship between VDD and persistence of MS, and particularly so with T2DM. 
      VDD could represent a predictor of MS persistence at 12 months after surgery.
FAU - Obispo Entrenas, Ana
AU  - Obispo Entrenas A
AD  - Department of Bariatric Surgery, Costa del Sol Hospital, Marbella, Malaga, Spain. 
      anabichop@hotmail.com.
FAU - Legupin Tubio, David
AU  - Legupin Tubio D
AD  - Department of Gastroenterology Surgery, Costa del Sol Hospital, Marbella, Malaga, 
      Spain.
FAU - Lucena Navarro, Fabiola
AU  - Lucena Navarro F
AD  - Department of Bariatric Surgery, Costa del Sol Hospital, Marbella, Malaga, Spain.
FAU - Martin Carvajal, Francisco
AU  - Martin Carvajal F
AD  - Department of Bariatric Surgery, Costa del Sol Hospital, Marbella, Malaga, Spain.
FAU - Gandara Adan, Norberto
AU  - Gandara Adan N
AD  - Department of Bariatric Surgery, Costa del Sol Hospital, Marbella, Malaga, Spain.
FAU - Redondo Bautista, Maximino
AU  - Redondo Bautista M
AD  - Department of Surgical Specialties, Biochemical and Immunological, Faculty of 
      Medicine, Malaga University, Malaga, Spain.
FAU - Abiles Osinaga, Jimena
AU  - Abiles Osinaga J
AD  - Department of Clinical Nutrition, Costa del Sol Hospital, Marbella, Malaga, 
      Spain.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Obes Surg
JT  - Obesity surgery
JID - 9106714
SB  - IM
EIN - Obes Surg. 2017 May;27(5):1229-1232. PMID: 28035524
MH  - Adult
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/epidemiology
MH  - Dyslipidemias/epidemiology
MH  - Female
MH  - *Gastrectomy
MH  - *Gastric Bypass
MH  - Humans
MH  - Hypertension/epidemiology
MH  - Laparoscopy
MH  - Male
MH  - Metabolic Syndrome/complications/*epidemiology
MH  - Middle Aged
MH  - Obesity, Morbid/epidemiology/*surgery
MH  - Retrospective Studies
MH  - Vitamin D Deficiency/complications/*epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Laparoscopic
OT  - Laparoscopic Roux-en-Y gastric bypass
OT  - Metabolic syndrome
OT  - Obesity
OT  - Sleeve gastrectomy
OT  - Vitamin D deficiency
EDAT- 2016/11/20 06:00
MHDA- 2017/12/27 06:00
CRDT- 2016/11/20 06:00
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/12/27 06:00 [medline]
PHST- 2016/11/20 06:00 [entrez]
AID - 10.1007/s11695-016-2445-0 [pii]
AID - 10.1007/s11695-016-2445-0 [doi]
PST - ppublish
SO  - Obes Surg. 2017 May;27(5):1222-1228. doi: 10.1007/s11695-016-2445-0.