PMID- 27864812
OWN - NLM
STAT- MEDLINE
DCOM- 20170717
LR  - 20181202
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Linking)
VI  - 16
IP  - 11
DP  - 2016 Nov
TI  - How In Vitro Assays Contribute to Allergy Diagnosis.
PG  - 82
AB  - Diagnosis of allergic disorders is based upon the clinical history of the 
      disease, the immunoglobulin E (IgE) antibody response, and the allergen exposure. 
      During the last decade, many changes have occurred in the in vitro diagnostic 
      tests used in daily practice. The most important one is the use of allergenic 
      molecules, which helps to define severe profile of allergy and/or to better 
      understand cross-reactivity. The correlation between IgE sensitization and 
      bronchial or nasal response in provocation tests is not so clear, which implies 
      that such tests are still helpful in allergy diagnosis. In order to strengthen 
      the link between a real allergen exposure and allergic symptoms, environmental 
      allergen load assessment can be performed. For clinicians, it appears obvious to 
      know the pollen count to treat their patients; however, they rarely measure the 
      allergen load in the indoor environment, while nowadays home-tests 
      (semi-quantitative or quantitative) make the assessment very easy. In the future, 
      assessment of the environmental exposure (preferably with an indoor technician) 
      of an allergic patient should take into account not only the allergens but also 
      the other indoor pollutants, which could enhance respiratory symptoms in allergic 
      patients.
FAU - Casset, Anne
AU  - Casset A
AD  - Faculty of Pharmacy, Laboratory of Conception and Application of Bioactive 
      Molecules, CNRS, University of Strasbourg, BP 60024, 67401, Illkirch Cedex, 
      France.
FAU - Khayath, Naji
AU  - Khayath N
AD  - Chest Diseases Department, Strasbourg University Hospital; Federation of 
      Translational Medicine, University of Strasbourg, BP 426, 67091, Strasbourg, 
      France.
FAU - de Blay, Frederic
AU  - de Blay F
AD  - Chest Diseases Department, Strasbourg University Hospital; Federation of 
      Translational Medicine, University of Strasbourg, BP 426, 67091, Strasbourg, 
      France. frederic.deblay@chru-strasbourg.fr.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Humans
MH  - Hypersensitivity/*diagnosis/immunology
MH  - Immunoglobulin E/*immunology
MH  - In Vitro Techniques
OTO - NOTNLM
OT  - Diagnosis
OT  - Environmental assessment
OT  - IgE
OT  - Inhalant allergens
OT  - Molecular allergology
EDAT- 2016/11/20 06:00
MHDA- 2017/07/18 06:00
CRDT- 2016/11/20 06:00
PHST- 2016/11/20 06:00 [entrez]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/07/18 06:00 [medline]
AID - 10.1007/s11882-016-0659-9 [pii]
AID - 10.1007/s11882-016-0659-9 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2016 Nov;16(11):82. doi: 10.1007/s11882-016-0659-9.