PMID- 27865040 OWN - NLM STAT- MEDLINE DCOM- 20180314 LR - 20230124 IS - 1600-6143 (Electronic) IS - 1600-6135 (Print) IS - 1600-6135 (Linking) VI - 17 IP - 5 DP - 2017 May TI - Psychological Outcomes of Living Liver Donors From a Multicenter Prospective Study: Results From the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A2ALL-2). PG - 1267-1277 LID - 10.1111/ajt.14134 [doi] AB - Although single-center and cross-sectional studies have suggested a modest impact of liver donation on donor psychological well-being, few studies have assessed these outcomes prospectively among a large cohort. We conducted one of the largest, prospective, multicenter studies of psychological outcomes in living liver donors within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A2ALL-2) consortium. In total, 271 (91%) of 297 eligible donors were interviewed at least once before donation and at 3, 6, 12, and 24 mo after donation using validated measures. We found that living liver donors reported low rates of major depressive (0-3%), alcohol abuse (2-5%), and anxiety syndromes (2-3%) at any given assessment in their first 2 years after donation. Between 4.7% and 9.6% of donors reported impaired mental well-being at various time points. We identified significant predictors for donors' perceptions of being better people and experiencing psychological growth following donation, including age, sex, relationship to recipient, ambivalence and motivation regarding donation, and feeling that donation would make life more worthwhile. Our results highlight the need for close psychosocial monitoring for those donors whose recipients died (n=27); some of those donors experienced guilt and concerns about responsibility. Careful screening and targeted, data-driven follow-up hold promise for optimizing psychological outcomes following this procedure for potentially vulnerable donors. CI - (c) 2016 The American Society of Transplantation and the American Society of Transplant Surgeons. FAU - Butt, Z AU - Butt Z AD - Departments of Medical Social Sciences, Surgery & Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL. FAU - Dew, M A AU - Dew MA AUID- ORCID: 0000-0002-4666-1870 AD - Departments of Psychiatry, Surgery, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA. FAU - Liu, Q AU - Liu Q AD - Arbor Research Collaborative for Health, Ann Arbor, MI. FAU - Simpson, M A AU - Simpson MA AD - Department of Transplantation, Lahey Hospital and Medical Center, Burlington, MA. FAU - Smith, A R AU - Smith AR AD - Arbor Research Collaborative for Health, Ann Arbor, MI. AD - Department of Biostatistics, University of Michigan, Ann Arbor, MI. FAU - Zee, J AU - Zee J AD - Arbor Research Collaborative for Health, Ann Arbor, MI. FAU - Gillespie, B W AU - Gillespie BW AD - Department of Biostatistics, University of Michigan, Ann Arbor, MI. FAU - Abbey, S E AU - Abbey SE AD - Department of Psychiatry and Transplantation, University Health Network, University of Toronto, Toronto, Ontario, Canada. FAU - Ladner, D P AU - Ladner DP AD - Departments of Medical Social Sciences, Surgery & Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL. FAU - Weinrieb, R AU - Weinrieb R AD - Department of Psychiatry, University of Pennsylvania, Philadelphia, PA. FAU - Fisher, R A AU - Fisher RA AD - Division of Transplantation, The Transplant Institute Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. FAU - Hafliger, S AU - Hafliger S AD - Department of Psychiatry, Columbia University, New York, NY. FAU - Terrault, N AU - Terrault N AD - Departments of Medicine and Surgery, University of California at San Francisco, San Francisco, CA. FAU - Burton, J AU - Burton J AD - Department of Medicine, University of Colorado, Denver, Aurora, CO. FAU - Sherker, A H AU - Sherker AH AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. FAU - DiMartini, A AU - DiMartini A AD - Departments of Psychiatry, Surgery, and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA. LA - eng GR - U01 DK062496/DK/NIDDK NIH HHS/United States GR - U01 DK062536/DK/NIDDK NIH HHS/United States GR - U01 DK062531/DK/NIDDK NIH HHS/United States GR - U01 DK062498/DK/NIDDK NIH HHS/United States GR - U01 DK062444/DK/NIDDK NIH HHS/United States GR - U01 DK085515/DK/NIDDK NIH HHS/United States GR - U01 DK062505/DK/NIDDK NIH HHS/United States GR - U01 DK062484/DK/NIDDK NIH HHS/United States GR - U01 DK062494/DK/NIDDK NIH HHS/United States GR - U01 DK062483/DK/NIDDK NIH HHS/United States GR - U01 DK062467/DK/NIDDK NIH HHS/United States GR - U01 DK085587/DK/NIDDK NIH HHS/United States GR - U01 DK085563/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Multicenter Study DEP - 20170103 PL - United States TA - Am J Transplant JT - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JID - 100968638 SB - IM MH - Adult MH - Cross-Sectional Studies MH - Depressive Disorder, Major/epidemiology/*psychology MH - Female MH - Follow-Up Studies MH - Graft Survival MH - Humans MH - Liver Transplantation/*psychology MH - Living Donors/*psychology MH - Male MH - Prognosis MH - Prospective Studies MH - *Quality of Life MH - Surveys and Questionnaires PMC - PMC5612366 MID - NIHMS905990 OTO - NOTNLM OT - clinical research/practice OT - depression OT - donors and donation OT - donors and donation: donor evaluation OT - donors and donation: donor follow-up OT - donors and donation: living OT - liver transplantation/hepatology EDAT- 2016/11/20 06:00 MHDA- 2018/03/15 06:00 PMCR- 2018/05/01 CRDT- 2016/11/20 06:00 PHST- 2016/09/16 00:00 [received] PHST- 2016/10/21 00:00 [revised] PHST- 2016/11/08 00:00 [accepted] PHST- 2016/11/20 06:00 [pubmed] PHST- 2018/03/15 06:00 [medline] PHST- 2016/11/20 06:00 [entrez] PHST- 2018/05/01 00:00 [pmc-release] AID - S1600-6135(22)24977-6 [pii] AID - 10.1111/ajt.14134 [doi] PST - ppublish SO - Am J Transplant. 2017 May;17(5):1267-1277. doi: 10.1111/ajt.14134. Epub 2017 Jan 3.