PMID- 27865184
OWN - NLM
STAT- MEDLINE
DCOM- 20171117
LR  - 20220331
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 228
DP  - 2017 Feb 1
TI  - Changes of left ventricular mechanics after trans-catheter aortic valve 
      implantation and surgical aortic valve replacement for severe aortic stenosis: A 
      tissue-tracking cardiac magnetic resonance study.
PG  - 184-190
LID - S0167-5273(16)33677-4 [pii]
LID - 10.1016/j.ijcard.2016.11.200 [doi]
AB  - BACKGROUND: Left ventricular (LV) mechanics are impaired in patients with severe 
      aortic stenosis (AS). The aim of the present study was to assess their changes 
      early and late after trans-catheter aortic valve implantation (TAVI) and surgical 
      aortic valve replacement (AVR) using cardiac magnetic resonance (CMR) 
      tissue-tracking imaging. METHODS: In 59 patients with severe AS undergoing either 
      TAVI (n=35) or surgical AVR (n=24), CMR with late gadolinium enhancement (LGE) 
      imaging was performed before and early post-procedure to evaluate LV function and 
      mass, and presence/extent of LGE. A third CMR scan was performed in 29 patients 
      after a mean follow-up of 15+/-4months. Tissue-tracking analysis was applied to 
      cine CMR images, to assess LV global longitudinal (GLS), circumferential (GCS) 
      and radial (GRS) strains. RESULTS: The TAVI and surgical AVR groups were similar 
      with respect to baseline (p=0.14) and early post-procedure (p=0.16) LV ejection 
      fraction. However, baseline LV GLS was significantly impaired in TAVI patients 
      compared to surgical AVR patients (p=0.025). Early post-procedure, TAVI resulted 
      in a significant improvement of LV GLS (p=0.003), while a significant worsening 
      of LV GLS was observed early after surgical AVR (p=0.012). At longer term 
      follow-up, both TAVI and surgical AVR groups experienced a significant reduction 
      of LV mass and a significant improvement of LV myocardial mechanics in all the 
      three directions. CONCLUSIONS: Treatment-specific differences in the changes of 
      LV myocardial mechanics early after afterload release by TAVI and surgical AVR 
      are present. Later, both interventions are associated with an improvement of LV 
      myocardial deformation, alongside a regression of LV hypertrophy.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Nucifora, Gaetano
AU  - Nucifora G
AD  - Department of Hearth Health, South Australian Health & Medical Research 
      Institute, Adelaide, Australia; Flinders University, Bedford Park, Adelaide, 
      Australia. Electronic address: gaetano.nucifora@sahmri.com.
FAU - Tantiongco, John-Paul
AU  - Tantiongco JP
AD  - Department of Hearth Health, South Australian Health & Medical Research 
      Institute, Adelaide, Australia; Department of Cardiovascular Medicine, Flinders 
      Medical Centre, Bedford Park, Adelaide, Australia; Flinders University, Bedford 
      Park, Adelaide, Australia.
FAU - Crouch, Gareth
AU  - Crouch G
AD  - Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, 
      Adelaide, Australia; Flinders University, Bedford Park, Adelaide, Australia.
FAU - Bennetts, Jayme
AU  - Bennetts J
AD  - Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, 
      Adelaide, Australia; Flinders University, Bedford Park, Adelaide, Australia.
FAU - Sinhal, Ajay
AU  - Sinhal A
AD  - Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, 
      Adelaide, Australia; Flinders University, Bedford Park, Adelaide, Australia.
FAU - Tully, Phillip J
AU  - Tully PJ
AD  - Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, 
      Adelaide, Australia; Flinders University, Bedford Park, Adelaide, Australia.
FAU - Bradbrook, Craig
AU  - Bradbrook C
AD  - Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, 
      Adelaide, Australia.
FAU - Baker, Robert A
AU  - Baker RA
AD  - Department of Cardiovascular Medicine, Flinders Medical Centre, Bedford Park, 
      Adelaide, Australia; Flinders University, Bedford Park, Adelaide, Australia.
FAU - Selvanayagam, Joseph B
AU  - Selvanayagam JB
AD  - Department of Hearth Health, South Australian Health & Medical Research 
      Institute, Adelaide, Australia; Department of Cardiovascular Medicine, Flinders 
      Medical Centre, Bedford Park, Adelaide, Australia; Flinders University, Bedford 
      Park, Adelaide, Australia.
LA  - eng
PT  - Journal Article
DEP - 20161109
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/*diagnostic imaging/*physiopathology/surgery
MH  - Cohort Studies
MH  - Coronary Angiography
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Time Factors
MH  - *Transcatheter Aortic Valve Replacement
MH  - Treatment Outcome
MH  - Ventricular Function, Left/*physiology
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Cardiac magnetic resonance
OT  - Fibrosis
OT  - Hypertrophy
OT  - Myocardial mechanics
OT  - Tissue-tracking
EDAT- 2016/11/20 06:00
MHDA- 2017/11/29 06:00
CRDT- 2016/11/20 06:00
PHST- 2016/08/31 00:00 [received]
PHST- 2016/11/06 00:00 [accepted]
PHST- 2016/11/20 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2016/11/20 06:00 [entrez]
AID - S0167-5273(16)33677-4 [pii]
AID - 10.1016/j.ijcard.2016.11.200 [doi]
PST - ppublish
SO  - Int J Cardiol. 2017 Feb 1;228:184-190. doi: 10.1016/j.ijcard.2016.11.200. Epub 
      2016 Nov 9.