PMID- 27865696
OWN - NLM
STAT- MEDLINE
DCOM- 20170703
LR  - 20181113
IS  - 1532-8511 (Electronic)
IS  - 1052-3057 (Print)
IS  - 1052-3057 (Linking)
VI  - 26
IP  - 4
DP  - 2017 Apr
TI  - Strength Training for Skeletal Muscle Endurance after Stroke.
PG  - 787-794
LID - S1052-3057(16)30420-7 [pii]
LID - 10.1016/j.jstrokecerebrovasdis.2016.10.018 [doi]
AB  - BACKGROUND AND PURPOSE: Initial studies support the use of strength training (ST) 
      as a safe and effective intervention after stroke. Our previous work shows that 
      relatively aggressive, higher intensity ST translates into large effect sizes for 
      paretic and non-paretic leg muscle volume, myostatin expression, and maximum 
      strength post-stroke. An unanswered question pertains to how our unique ST model 
      for stroke impacts skeletal muscle endurance (SME). Thus, we now report on 
      ST-induced adaptation in the ability to sustain isotonic muscle contraction. 
      METHODS: Following screening and baseline testing, hemiparetic stroke 
      participants were randomized to either ST or an attention-matched stretch control 
      group (SC). Those in the ST group trained each leg individually to muscle failure 
      (20 repetition sets, 3x per week for 3 months) on each of three pneumatic 
      resistance machines (leg press, leg extension, and leg curl). Our primary outcome 
      measure was SME, quantified as the number of submaximal weight leg press 
      repetitions possible at a specified cadence. The secondary measures included 
      one-repetition maximum strength, 6-minute walk distance (6MWD), 10-meter walk 
      speeds, and peak aerobic capacity (VO(2) peak). RESULTS: ST participants (N = 14) 
      had significantly greater SME gains compared with SC participants (N = 16) in 
      both the paretic (178% versus 12%, P < .01) and non-paretic legs (161% versus 
      12%, P < .01). These gains were accompanied by group differences for 6MWD 
      (P < .05) and VO(2) peak (P < .05). CONCLUSION: Our ST regimen had a large impact 
      on the capacity to sustain submaximal muscle contraction, a metric that may carry 
      more practical significance for stroke than the often reported measures of 
      maximum strength.
CI  - Published by Elsevier Inc.
FAU - Ivey, Frederick M
AU  - Ivey FM
AD  - Department of Veterans Affairs and Veterans Affairs Medical Center, Maryland 
      Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education 
      and Clinical Center (GRECC), University of Maryland School of Medicine, 
      Baltimore, Maryland; Department of Neurology. Electronic address: 
      fivey@grecc.umaryland.edu.
FAU - Prior, Steven J
AU  - Prior SJ
AD  - Department of Veterans Affairs and Veterans Affairs Medical Center, Maryland 
      Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education 
      and Clinical Center (GRECC), University of Maryland School of Medicine, 
      Baltimore, Maryland; Department of Medicine, Division of Gerontology and 
      Geriatric Medicine.
FAU - Hafer-Macko, Charlene E
AU  - Hafer-Macko CE
AD  - Department of Veterans Affairs and Veterans Affairs Medical Center, Maryland 
      Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education 
      and Clinical Center (GRECC), University of Maryland School of Medicine, 
      Baltimore, Maryland; Department of Neurology.
FAU - Katzel, Leslie I
AU  - Katzel LI
AD  - Department of Veterans Affairs and Veterans Affairs Medical Center, Maryland 
      Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education 
      and Clinical Center (GRECC), University of Maryland School of Medicine, 
      Baltimore, Maryland; Department of Medicine, Division of Gerontology and 
      Geriatric Medicine.
FAU - Macko, Richard F
AU  - Macko RF
AD  - Department of Veterans Affairs and Veterans Affairs Medical Center, Maryland 
      Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education 
      and Clinical Center (GRECC), University of Maryland School of Medicine, 
      Baltimore, Maryland; Department of Neurology.
FAU - Ryan, Alice S
AU  - Ryan AS
AD  - Department of Veterans Affairs and Veterans Affairs Medical Center, Maryland 
      Exercise and Robotics Center of Excellence (MERCE), Geriatric Research, Education 
      and Clinical Center (GRECC), University of Maryland School of Medicine, 
      Baltimore, Maryland; Department of Medicine, Division of Gerontology and 
      Geriatric Medicine.
LA  - eng
GR  - K23 AG040775/AG/NIA NIH HHS/United States
GR  - P30 AG028747/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20161116
PL  - United States
TA  - J Stroke Cerebrovasc Dis
JT  - Journal of stroke and cerebrovascular diseases : the official journal of National 
      Stroke Association
JID - 9111633
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/*physiology
MH  - Muscle, Skeletal/*physiopathology
MH  - Oxygen Consumption/physiology
MH  - Resistance Training/*methods
MH  - Stroke/*pathology/*physiopathology
MH  - *Stroke Rehabilitation
MH  - Treatment Outcome
MH  - Walking
PMC - PMC5947878
MID - NIHMS964697
OTO - NOTNLM
OT  - Stroke recovery
OT  - endurance
OT  - exercise
OT  - strength training
OT  - stroke rehabilitation
EDAT- 2016/11/21 06:00
MHDA- 2017/07/04 06:00
PMCR- 2018/05/11
CRDT- 2016/11/21 06:00
PHST- 2016/08/22 00:00 [received]
PHST- 2016/10/05 00:00 [revised]
PHST- 2016/10/19 00:00 [accepted]
PHST- 2016/11/21 06:00 [pubmed]
PHST- 2017/07/04 06:00 [medline]
PHST- 2016/11/21 06:00 [entrez]
PHST- 2018/05/11 00:00 [pmc-release]
AID - S1052-3057(16)30420-7 [pii]
AID - 10.1016/j.jstrokecerebrovasdis.2016.10.018 [doi]
PST - ppublish
SO  - J Stroke Cerebrovasc Dis. 2017 Apr;26(4):787-794. doi: 
      10.1016/j.jstrokecerebrovasdis.2016.10.018. Epub 2016 Nov 16.