PMID- 27867073
OWN - NLM
STAT- MEDLINE
DCOM- 20180123
LR  - 20191210
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 40
DP  - 2017 Feb
TI  - Immune status assessment in adult lung transplant candidates.
PG  - 31-34
LID - S0966-3274(16)30123-X [pii]
LID - 10.1016/j.trim.2016.11.001 [doi]
AB  - BACKGROUND: Lung transplant recipients have an increased susceptibility to a 
      variety of infections due to immunosuppressive therapy. Current guidelines 
      recommend pneumococcal and other vaccinations, prior to lung transplantation to 
      protect against post-transplant infections, but measurement of the antibody 
      response to vaccination is not advised. Immune status investigation in lung 
      transplant candidates, including the response to pneumococcal polysaccharide 
      vaccination, has not been described. METHODS: Immune status investigation, 
      including measurement of immunoglobulins, complement and the response to 
      23-valent pneumococcal polysaccharide vaccination (23vPPV) was performed in 81 
      adult lung transplant candidates. RESULTS: Eighteen patients had low IgG levels 
      and 32 patients had low IgG1 and/or IgG2 levels. After vaccination with 23vPPV 
      the median antibody concentration of all serotypes increased significantly. 
      Fifty-two patients had protective IgG-post-vaccination antibody levels to at 
      least 10 serotypes. Twenty-nine patients had an impaired response to 23vPPV. 
      CONCLUSIONS: In conclusion, a significant proportion of our cohort of lung 
      transplant candidates had one or more abnormalities in the immune status. It is 
      likely that these patients have an increased risk for infections after 
      transplantation. Revaccination, including measurement of antibody response, and 
      possibly antibody replacement therapy should be considered to minimize infection 
      risk.
CI  - Copyright (c) 2016 Elsevier B.V. All rights reserved.
FAU - van Kessel, Diana A
AU  - van Kessel DA
AD  - Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands; 
      Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The 
      Netherlands. Electronic address: d.kessel@antoniusziekenhuis.nl.
FAU - Hoffman, Thijs W
AU  - Hoffman TW
AD  - Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands.
FAU - van Velzen-Blad, Heleen
AU  - van Velzen-Blad H
AD  - Department of Medical Microbiology and Immunology, St. Antonius Hospital, 
      Nieuwegein, The Netherlands.
FAU - van de Graaf, Ed A
AU  - van de Graaf EA
AD  - Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Grutters, Jan C
AU  - Grutters JC
AD  - Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands; 
      Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The 
      Netherlands.
FAU - Rijkers, Ger T
AU  - Rijkers GT
AD  - Department of Medical Microbiology and Immunology, St. Antonius Hospital, 
      Nieuwegein, The Netherlands; Department of Science, University College Roosevelt, 
      Middelburg, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20161117
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (Immunoglobulins)
RN  - 0 (Pneumococcal Vaccines)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Immunity, Humoral
MH  - Immunocompromised Host
MH  - Immunoglobulins/*blood
MH  - Infections/etiology/*immunology
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Immunologic/methods
MH  - Pneumococcal Vaccines/*immunology
MH  - Postoperative Complications/*immunology
MH  - Risk
MH  - Transplant Recipients
MH  - Vaccination
MH  - Waiting Lists
MH  - Young Adult
OTO - NOTNLM
OT  - Immune status investigation
OT  - Lung transplant candidates
OT  - Pneumococcal polysaccharide vaccination
EDAT- 2016/11/22 06:00
MHDA- 2018/01/24 06:00
CRDT- 2016/11/22 06:00
PHST- 2016/09/21 00:00 [received]
PHST- 2016/10/27 00:00 [revised]
PHST- 2016/11/16 00:00 [accepted]
PHST- 2016/11/22 06:00 [pubmed]
PHST- 2018/01/24 06:00 [medline]
PHST- 2016/11/22 06:00 [entrez]
AID - S0966-3274(16)30123-X [pii]
AID - 10.1016/j.trim.2016.11.001 [doi]
PST - ppublish
SO  - Transpl Immunol. 2017 Feb;40:31-34. doi: 10.1016/j.trim.2016.11.001. Epub 2016 
      Nov 17.