PMID- 27867278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240324
IS  - 0973-1296 (Print)
IS  - 0976-4062 (Electronic)
IS  - 0973-1296 (Linking)
VI  - 12
IP  - 48
DP  - 2016 Oct-Dec
TI  - Effect of Methanolic Leaf Extract of Talinum triangulare (Jacq). Willd. on 
      Biochemical Parameters in Diet induced Dyslipidemia Wistar Rats.
PG  - 333-339
AB  - OBJECTIVE: To investigate the effect of methanolic leaf extract of Talinum 
      triangulare on hematological parameters, enzymatic and non-enzymatic antioxidant 
      status, and serum lipid in Wistar rats fed standard laboratory, or 2% 
      cholesterol-enrich diet. MATERIAL AND METHODS: Wistar rats (180-210g) divided 
      into six groups of six animals (males) each were fed 2% cholesterol-enriched diet 
      and orally treated with 0.9% saline or extract of Talinum triangulare (250, 500, 
      and 1000 mg/kg per body weight) daily for eight weeks. Lipid profile, lipid 
      peroxidation (MDA), hematological parameters, and their functional indices and 
      serum antioxidant enzymes (catalase, glutathione -S-transferase, and superoxide 
      dismutase) activities and glutathione status were assessed in normal and 
      diet-induced hypercholesterolemic extract treated rats and compared with the rats 
      treated with 100 mg/kg per bwt standard drug gemfibrozil. RESULTS: A significant 
      (P < 0.05) increase in lipid profile (total glyceride, total cholestrol, 
      low-density lipoprotein, and very low-density lipoprotein), MDA and reduction (P 
      < 0.05) in enzymatic and nonenzymatic antioxidant status coupled with alterations 
      in hematological parameters was observed in the serum of hypercholesterolemic 
      rats when compared with animals on a normal diet. Coadministration of methanolic 
      leaf extracts of Talinum triangulare or gemfibrozil significantly (P < 0.05) 
      restored the elevated serum lipid profile, MDA, and the deranged hematological 
      parameters to near normal. The extract also protected against 
      hypercholesterolemic-induced diminished enzymatic and nonenzymatic antioxidant 
      status. The activities of the plant extract are dose (250, 500, and 1000 mg/kg) 
      dependent and it compared favorably with the standard drug gemfibrozil. 
      CONCLUSION: The present study suggested that the extract of Talinum triangulare 
      might protect against hypercholesterolemic-induced altered lipid profiles, 
      oxidative stress, and also improve the status of antioxidant defense system and 
      hematopoiesis. SUMMARY: Elevated lipid profile (total glyceride, total 
      cholestrol, low-density lipoprotein, and very low-density lipoprotein), lipid 
      peroxidation (MDA), and reduced enzymatic and nonenzymatic antioxidant status 
      coupled with alterations in hematological parameters was observed in the serum of 
      hypercholesterolemic rats when compared with animals on a normal 
      dietCoadministration of methanolic leaf extracts of Talinum triangulare 
      significantly (P < 0.05) restored the elevated serum lipid profile, MDA, and the 
      deranged hematological parameters to near normal.The extract also protected 
      against hypercholesterolemic-induced diminished enzymatic and bnonenzymatic 
      antioxidant status.The activities of the plant extract was dose-dependent and it 
      compared favorably with the standard drug gemfibrozil. Abbreviations used: Lipid 
      peroxidation (MDA), (catalase (CAT), glutathione-S-transferase (GST), superoxide 
      dismutase (SOD), glutathione (GSH), Thrombocytes indices (PLT), Red blood cell 
      (RBC), Packed cell volume (PVC), Mean corpuscular hemoglobin(MCH), Mean 
      corpuscular hemoglobin concentration (MCHC), Total glyceride (TG), Very low 
      density lipoprotein (VLDL), Total cholesterol (TC), Low density lipoprotein 
      (LDL), High density lipoprotein (HDL) and 3-Hydroxy-3-methyl-glutaryl-CoA 
      reductase(HMG-CoA).
FAU - Olorunnisola, Olubukola Sinbad
AU  - Olorunnisola OS
AD  - Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, 
      Oyo State, Nigeria; Medicinal Plant and Economic Development (MPED) Research 
      Center. University of Fort Hare, Alice, South Africa.
FAU - Adetutu, Adewale
AU  - Adetutu A
AD  - Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, 
      Oyo State, Nigeria.
FAU - Afolayan, Anthony Jide
AU  - Afolayan AJ
AD  - Medicinal Plant and Economic Development (MPED) Research Center. University of 
      Fort Hare, Alice, South Africa.
FAU - Owoade, Abiodun Olusoji
AU  - Owoade AO
AD  - Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, 
      Oyo State, Nigeria.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pharmacogn Mag
JT  - Pharmacognosy magazine
JID - 101300403
PMC - PMC5096282
OTO - NOTNLM
OT  - Talinum triangulare
OT  - anti-lipidemia
OT  - antioxidant
OT  - antioxidant enzymes
OT  - hematopoiesis
EDAT- 2016/11/22 06:00
MHDA- 2016/11/22 06:01
PMCR- 2016/10/01
CRDT- 2016/11/22 06:00
PHST- 2016/11/22 06:00 [entrez]
PHST- 2016/11/22 06:00 [pubmed]
PHST- 2016/11/22 06:01 [medline]
PHST- 2016/10/01 00:00 [pmc-release]
AID - PM-12-333 [pii]
AID - 10.4103/0973-1296.192194 [doi]
PST - ppublish
SO  - Pharmacogn Mag. 2016 Oct-Dec;12(48):333-339. doi: 10.4103/0973-1296.192194.