PMID- 27871787
OWN - NLM
STAT- MEDLINE
DCOM- 20171025
LR  - 20190318
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Linking)
VI  - 72
DP  - 2017 Jan
TI  - Selfish brain and selfish immune system interplay: A theoretical framework for 
      metabolic comorbidities of mood disorders.
PG  - 43-49
LID - S0149-7634(16)30511-5 [pii]
LID - 10.1016/j.neubiorev.2016.11.010 [doi]
AB  - According to the "selfish brain" theory, the brain regulates its own energy 
      supply influencing the peripheral metabolism and food intake according to its 
      needs. The immune system has been likewise "selfish" due to independent energy 
      consumption; and it may compete with the brain (another high energy-consumer) for 
      glucose. In mood disorders, stress in mood episodes or physiological stress 
      activate homeostasis mechanisms from the brain and the immune system to solve the 
      imbalance. The interaction between the selfish brain and the selfish immune 
      system may explain various conditions of medical impairment in mood disorders, 
      such as Metabolic Syndrome (MetS), obesity, type 2 diabetes mellitus (T2DM) and 
      immune dysregulation. The objective of this study is to comprehensively review 
      the literature regarding the competition between the brain and the immune system 
      for energy substrate. Targeting the energetic regulation of the brain and the 
      immune system and their cross-talk open alternative treatments and a different 
      approach in the study of general medical comorbidities in mood disorders, 
      although more investigation is needed.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Yamagata, Ana Sayuri
AU  - Yamagata AS
AD  - Institute of Biosciences University of Sao Paulo (USP). R. do Matao, 14, 321 - 
      Butanta, Sao Paulo, SP, 05508-090, Brazil,; Research Group of Behavioral and 
      Molecular Neuroscience of Bipolar Disorder, Department of Psychiatry, Federal 
      University of Sao Paulo (Unifesp). R. Pedro de Toledo, 669-3rd Floor, Vila 
      Clementino, Sao Paulo, SP, CEP 04039-032, Brazil. Electronic address: 
      ana.yamagata@usp.br.
FAU - Mansur, Rodrigo Barbachan
AU  - Mansur RB
AD  - Research Group of Behavioral and Molecular Neuroscience of Bipolar Disorder, 
      Department of Psychiatry, Federal University of Sao Paulo (Unifesp). R. Pedro de 
      Toledo, 669-3rd Floor, Vila Clementino, Sao Paulo, SP, CEP 04039-032, Brazil; 
      Mood Disorders Psychopharmachology Unit (MDPU), University of Toronto. 399 
      Bathurst Street, MP 9-325, Toronto, Ontario, M5T 2S8, Canada.
FAU - Rizzo, Lucas Bortolotto
AU  - Rizzo LB
AD  - Research Group of Behavioral and Molecular Neuroscience of Bipolar Disorder, 
      Department of Psychiatry, Federal University of Sao Paulo (Unifesp). R. Pedro de 
      Toledo, 669-3rd Floor, Vila Clementino, Sao Paulo, SP, CEP 04039-032, Brazil.
FAU - Rosenstock, Tatiana
AU  - Rosenstock T
AD  - Department of Physiological Science, Santa Casa de Sao Paulo Medical School. R. 
      Doutor Cesario Motta Junior, 61 - Vila Buarque, Sao Paulo - SP, 01221-020 Brazil.
FAU - McIntyre, Roger S
AU  - McIntyre RS
AD  - Mood Disorders Psychopharmachology Unit (MDPU), University of Toronto. 399 
      Bathurst Street, MP 9-325, Toronto, Ontario, M5T 2S8, Canada.
FAU - Brietzke, Elisa
AU  - Brietzke E
AD  - Research Group of Behavioral and Molecular Neuroscience of Bipolar Disorder, 
      Department of Psychiatry, Federal University of Sao Paulo (Unifesp). R. Pedro de 
      Toledo, 669-3rd Floor, Vila Clementino, Sao Paulo, SP, CEP 04039-032, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161118
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
SB  - IM
MH  - *Brain
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2
MH  - Humans
MH  - *Immune System
MH  - Mood Disorders/*metabolism
OTO - NOTNLM
OT  - *Bipolar disorder
OT  - *Brain energy metabolism
OT  - *Immune system energy metabolism
OT  - *Inflammation
OT  - *Major depressive disorder
OT  - *Metabolic syndrome
EDAT- 2016/11/23 06:00
MHDA- 2017/10/27 06:00
CRDT- 2016/11/23 06:00
PHST- 2016/08/29 00:00 [received]
PHST- 2016/10/06 00:00 [revised]
PHST- 2016/11/16 00:00 [accepted]
PHST- 2016/11/23 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2016/11/23 06:00 [entrez]
AID - S0149-7634(16)30511-5 [pii]
AID - 10.1016/j.neubiorev.2016.11.010 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2017 Jan;72:43-49. doi: 10.1016/j.neubiorev.2016.11.010. 
      Epub 2016 Nov 18.