PMID- 27872728
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2035-3006 (Print)
IS  - 2035-3006 (Electronic)
IS  - 2035-3006 (Linking)
VI  - 8
IP  - 1
DP  - 2016
TI  - What Unrelated Hematopoietic Stem Cell Transplantation in Thalassemia Taught us 
      about Transplant Immunogenetics.
PG  - e2016048
LID - e2016048
AB  - Although the past few decades have shown an improvement in the survival and 
      complication-free survival rates in patients with beta-thalassemia major and gene 
      therapy is already at an advanced stage of experimentation, hematopoietic stem 
      cell transplantation (HSCT) continues to be the only effective and realistic 
      approach to the cure of this chronic non-malignant disease. Historically, human 
      leukocyte antigen (HLA)-matched siblings have been the preferred source of donor 
      cells owing to superior outcomes compared with HSCT from other sources. Nowadays, 
      the availability of an international network of voluntary stem cell donor 
      registries and cord blood banks has significantly increased the odds of finding a 
      suitable HLA matched donor. Stringent immunogenetic criteria for donor selection 
      have made it possible to achieve overall survival (OS) and thalassemia-free 
      survival (TFS) rates comparable to those of sibling transplants. However, acute 
      and chronic graft-versus-host disease (GVHD) remains the most important 
      complication in unrelated HSCT in thalassemia, leading to significant rates of 
      morbidity and mortality for a chronic non-malignant disease. A careful 
      immunogenetic assessment of donors and recipients makes it possible to 
      individualize appropriate strategies for its prevention and management. This 
      review provides an overview of recent insights about immunogenetic factors 
      involved in GVHD, which seem to have a potential role in the outcome of 
      transplantation for thalassemia.
FAU - La Nasa, Giorgio
AU  - La Nasa G
AD  - Bone Marrow Transplant Center, R. Binaghi Hospital - ASL 8, Cagliari, Italy; 
      Hematology Unit, Department of Medical Sciences, University of Cagliari, Italy.
FAU - Vacca, Adriana
AU  - Vacca A
AD  - Bone Marrow Transplant Center, R. Binaghi Hospital - ASL 8, Cagliari, Italy.
FAU - Littera, Roberto
AU  - Littera R
AD  - Regional Transplant Center, R. Binaghi Hospital - ASL 8, Cagliari, Italy.
FAU - Piras, Eugenia
AU  - Piras E
AD  - Bone Marrow Transplant Center, R. Binaghi Hospital - ASL 8, Cagliari, Italy.
FAU - Orru, Sandro
AU  - Orru S
AD  - Medical Genetics, Department of Medical Sciences, University of Cagliari, Italy.
FAU - Greco, Marianna
AU  - Greco M
AD  - Bone Marrow Transplant Center, R. Binaghi Hospital - ASL 8, Cagliari, Italy.
FAU - Carcassi, Carlo
AU  - Carcassi C
AD  - Medical Genetics, Department of Medical Sciences, University of Cagliari, Italy.
FAU - Caocci, Giovanni
AU  - Caocci G
AD  - Bone Marrow Transplant Center, R. Binaghi Hospital - ASL 8, Cagliari, Italy; 
      Hematology Unit, Department of Medical Sciences, University of Cagliari, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20161020
PL  - Italy
TA  - Mediterr J Hematol Infect Dis
JT  - Mediterranean journal of hematology and infectious diseases
JID - 101530512
PMC - PMC5111522
COIS- Financial and Competing Interests Disclosure. The authors have no relevant 
      affiliations or financial involvement with any organization or entity with a 
      financial interest in or financial conflict with the subject matter or materials 
      discussed in the manuscript. This includes employment, consultancies, honoraria, 
      stock ownership or options, expert testimony, grants or patents received or 
      pending, or royalties.
EDAT- 2016/11/23 06:00
MHDA- 2016/11/23 06:01
PMCR- 2016/01/01
CRDT- 2016/11/23 06:00
PHST- 2016/08/04 00:00 [received]
PHST- 2016/09/16 00:00 [accepted]
PHST- 2016/11/23 06:00 [entrez]
PHST- 2016/11/23 06:00 [pubmed]
PHST- 2016/11/23 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - mjhid-8-1-e2016048 [pii]
AID - 10.4084/MJHID.2016.048 [doi]
PST - epublish
SO  - Mediterr J Hematol Infect Dis. 2016 Oct 20;8(1):e2016048. doi: 
      10.4084/MJHID.2016.048. eCollection 2016.