PMID- 27873521
OWN - NLM
STAT- MEDLINE
DCOM- 20170217
LR  - 20181202
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 58
IP  - 1
DP  - 2017 Jan
TI  - A Case of Recurrent Urticaria Due to Formaldehyde Release from Root-Canal 
      Disinfectant.
PG  - 252-254
LID - 10.3349/ymj.2017.58.1.252 [doi]
AB  - Although formaldehyde is well known to cause type 4 hypersensitivity, 
      immunoglobulin E (IgE)-mediated hypersensitivity to formaldehyde is rare. Here, 
      we report a case of recurrent generalized urticaria after endodontic treatment 
      using a para-formaldehyde (PFA)-containing root canal sealant and present a 
      review of previous studies describing cases of immediate hypersensitivity 
      reactions to formaldehyde. A 50-year-old man visited our allergy clinic for 
      recurrent generalized urticaria several hours after endodontic treatment. Prick 
      tests to latex, lidocaine, and formaldehyde showed negative reactions. However, 
      swelling and redness at the prick site continued for several days. The level of 
      formaldehyde-specific IgE was high (class 4). Thus, the patient was deemed to 
      have experienced an IgE-mediated hypersensitivity reaction caused by the PFA used 
      in the root canal disinfectant. Accordingly, we suggest that physicians should 
      pay attention to type I hypersensitivity reactions to root canal disinfectants, 
      even if the symptoms occur several hours after exposure.
FAU - Jang, Ji Hoon
AU  - Jang JH
AD  - Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 
      Korea.
FAU - Park, Seung Hyun
AU  - Park SH
AD  - Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 
      Korea.
FAU - Jang, Hang Jea
AU  - Jang HJ
AD  - Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 
      Korea.
FAU - Lee, Sung Geun
AU  - Lee SG
AD  - Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 
      Korea.
FAU - Park, Jin Han
AU  - Park JH
AD  - Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 
      Korea.
FAU - Jeong, Jae Won
AU  - Jeong JW
AD  - Department of Internal Medicine, Inje University Ilsan Paik Hospital, Ilsan, 
      Korea.
FAU - Park, Chan Sun
AU  - Park CS
AD  - Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, 
      Korea. chansun@paik.ac.kr.
LA  - eng
PT  - Case Reports
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (Disinfectants)
RN  - 0 (Zinc Oxide-Eugenol Cement)
RN  - 0 (canals sealer)
RN  - 1HG84L3525 (Formaldehyde)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Disinfectants/*adverse effects
MH  - Formaldehyde/*adverse effects
MH  - Humans
MH  - Hypersensitivity, Immediate/*chemically induced
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Middle Aged
MH  - Recurrence
MH  - Skin Tests
MH  - Time Factors
MH  - Urticaria/*chemically induced/diagnosis
MH  - Zinc Oxide-Eugenol Cement/*chemistry
PMC - PMC5122645
OTO - NOTNLM
OT  - Formaldehyde
OT  - type 1 hypersensitivity
OT  - urticaria
COIS- The authors have no financial conflicts of interest.
EDAT- 2016/11/23 06:00
MHDA- 2017/02/18 06:00
PMCR- 2017/01/01
CRDT- 2016/11/23 06:00
PHST- 2015/07/28 00:00 [received]
PHST- 2015/12/03 00:00 [revised]
PHST- 2015/12/10 00:00 [accepted]
PHST- 2016/11/23 06:00 [entrez]
PHST- 2016/11/23 06:00 [pubmed]
PHST- 2017/02/18 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 58.252 [pii]
AID - 10.3349/ymj.2017.58.1.252 [doi]
PST - ppublish
SO  - Yonsei Med J. 2017 Jan;58(1):252-254. doi: 10.3349/ymj.2017.58.1.252.