PMID- 2787531
OWN - NLM
STAT- MEDLINE
DCOM- 19890818
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 245
IP  - 4915
DP  - 1989 Jul 21
TI  - Antibody to interleukin-5 inhibits helminth-induced eosinophilia in mice.
PG  - 308-10
AB  - When rodents are infected with the nematode Nippostrongylus brasiliensis, large 
      numbers of eosinophils appear in their blood and lungs and their serum 
      immunoglobulin E (IgE) is increased. Injection of a monoclonal antibody to 
      interleukin-5 completely suppressed the blood eosinophilia and the infiltration 
      of eosinophils in the lungs of parasitized mice but had no effect on serum IgE. 
      In contrast, an antibody to interleukin-4 inhibited parasite-induced IgE but not 
      the eosinophilia. These results show that interleukin-5 is important in 
      eosinophil production in vivo and that IgE and eosinophil production are 
      regulated by different cytokines produced by the TH2 subset of CD4-expressing T 
      cells.
FAU - Coffman, R L
AU  - Coffman RL
AD  - DNAX Research Institute, Palo Alto, CA 94304.
FAU - Seymour, B W
AU  - Seymour BW
FAU - Hudak, S
AU  - Hudak S
FAU - Jackson, J
AU  - Jackson J
FAU - Rennick, D
AU  - Rennick D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Interleukin-5)
RN  - 0 (Interleukins)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/*immunology
MH  - Eosinophilia/etiology/*immunology
MH  - Immunoglobulin E/immunology
MH  - Interleukin-4
MH  - Interleukin-5
MH  - Interleukins/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Nematode Infections/*complications/immunology
MH  - Nippostrongylus
EDAT- 1989/07/21 00:00
MHDA- 1989/07/21 00:01
CRDT- 1989/07/21 00:00
PHST- 1989/07/21 00:00 [pubmed]
PHST- 1989/07/21 00:01 [medline]
PHST- 1989/07/21 00:00 [entrez]
AID - 10.1126/science.2787531 [doi]
PST - ppublish
SO  - Science. 1989 Jul 21;245(4915):308-10. doi: 10.1126/science.2787531.