PMID- 27876231
OWN - NLM
STAT- MEDLINE
DCOM- 20180205
LR  - 20181113
IS  - 1873-6823 (Electronic)
IS  - 0741-8329 (Print)
IS  - 0741-8329 (Linking)
VI  - 60
DP  - 2017 May
TI  - Paternal preconception alcohol exposure imparts intergenerational alcohol-related 
      behaviors to male offspring on a pure C57BL/6J background.
PG  - 169-177
LID - S0741-8329(16)30237-3 [pii]
LID - 10.1016/j.alcohol.2016.11.001 [doi]
AB  - While alcohol use disorder (AUD) is a highly heritable condition, the basis of 
      AUD in families with a history of alcoholism is difficult to explain by genetic 
      variation alone. Emerging evidence suggests that parental experience prior to 
      conception can affect inheritance of complex behaviors in offspring via 
      non-genomic (epigenetic) mechanisms. For instance, male C57BL/6J (B6) mice 
      exposed to chronic intermittent vapor ethanol (CIE) prior to mating with Strain 
      129S1/SvImJ ethanol-naive females produce male offspring with reduced 
      ethanol-drinking preference, increased ethanol sensitivity, and increased 
      brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area 
      (VTA). In the present study, we tested the hypothesis that these 
      intergenerational effects of paternal CIE are reproducible in male offspring on 
      an inbred B6 background. To this end, B6 males were exposed to 6 weeks of CIE (or 
      room air as a control) before mating with ethanol-naive B6 females to produce 
      ethanol (E)-sired and control (C)-sired male and female offspring. We observed a 
      sex-specific effect, as E-sired males exhibited decreased two-bottle free-choice 
      ethanol-drinking preference, increased sensitivity to the anxiolytic effects of 
      ethanol, and increased VTA BDNF expression; no differences were observed in 
      female offspring. These findings confirm and extend our previous results by 
      demonstrating that the effects of paternal preconception ethanol are reproducible 
      using genetically identical, inbred B6 animals.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Rompala, Gregory R
AU  - Rompala GR
AD  - Center for Neuroscience, University of Pittsburgh School of Medicine, 6068 
      Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA. 
      Electronic address: grr14@pitt.edu.
FAU - Finegersh, Andrey
AU  - Finegersh A
AD  - Department of Pharmacology & Chemical Biology, University of Pittsburgh School of 
      Medicine, 6068 Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 
      15261, USA. Electronic address: afinegersh@ucsd.edu.
FAU - Slater, Michelle
AU  - Slater M
AD  - Department of Neuroscience, University of Pittsburgh School of Medicine, 6068 
      Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA. 
      Electronic address: mas486@pitt.edu.
FAU - Homanics, Gregg E
AU  - Homanics GE
AD  - Center for Neuroscience, University of Pittsburgh School of Medicine, 6068 
      Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 15261, USA; 
      Department of Pharmacology & Chemical Biology, University of Pittsburgh School of 
      Medicine, 6068 Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 
      15261, USA; Department of Anesthesiology, University of Pittsburgh School of 
      Medicine, 6068 Biomedical Science Tower-3, 3501 Fifth Avenue, Pittsburgh, PA 
      15261, USA. Electronic address: homanicsge@anes.upmc.edu.
LA  - eng
GR  - F30 AA021632/AA/NIAAA NIH HHS/United States
GR  - F31 AA024670/AA/NIAAA NIH HHS/United States
GR  - R37 AA010422/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20161105
PL  - United States
TA  - Alcohol
JT  - Alcohol (Fayetteville, N.Y.)
JID - 8502311
RN  - 0 (Anti-Anxiety Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol Drinking/*genetics/psychology
MH  - Alcoholism/*genetics/psychology
MH  - Animals
MH  - Anti-Anxiety Agents/administration & dosage/*toxicity
MH  - Anxiety/genetics/prevention & control/psychology
MH  - Behavior, Animal/*drug effects
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Ethanol/administration & dosage/*toxicity
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Heredity
MH  - Inhalation Exposure
MH  - Male
MH  - Mice, 129 Strain
MH  - Mice, Inbred C57BL
MH  - Pedigree
MH  - Sex Factors
MH  - Time Factors
MH  - Ventral Tegmental Area/*drug effects/metabolism
PMC - PMC5419883
MID - NIHMS831161
OTO - NOTNLM
OT  - Alcohol drinking
OT  - Alcohol sensitivity
OT  - BDNF
OT  - Chronic intermittent vapor ethanol
OT  - Epigenetics
OT  - Stress
EDAT- 2016/11/24 06:00
MHDA- 2018/02/06 06:00
PMCR- 2018/05/01
CRDT- 2016/11/24 06:00
PHST- 2016/09/16 00:00 [received]
PHST- 2016/11/01 00:00 [revised]
PHST- 2016/11/03 00:00 [accepted]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2018/02/06 06:00 [medline]
PHST- 2016/11/24 06:00 [entrez]
PHST- 2018/05/01 00:00 [pmc-release]
AID - S0741-8329(16)30237-3 [pii]
AID - 10.1016/j.alcohol.2016.11.001 [doi]
PST - ppublish
SO  - Alcohol. 2017 May;60:169-177. doi: 10.1016/j.alcohol.2016.11.001. Epub 2016 Nov 
      5.