PMID- 27876568
OWN - NLM
STAT- MEDLINE
DCOM- 20170830
LR  - 20171219
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 118
DP  - 2017 Feb
TI  - Design, synthesis, and biological evaluation of steroidal analogs as 
      estrogenic/anti-estrogenic agents.
PG  - 32-40
LID - S0039-128X(16)30168-4 [pii]
LID - 10.1016/j.steroids.2016.11.005 [doi]
AB  - Series of estrone based analogs were synthetically investigated at positions C-9, 
      C-11, C-16, and C-17 positions, to be biologically evaluated via assessment of 
      cell proliferation, cytotoxicity, and estrogenic/anti-estrogenic activity. LA-7 
      and LA-10 revealed their potential to exhibit inhibitory estrogenic profile. This 
      was further validated by Estrogen Receptor-alpha (ER-alpha) and Estrogen Receptor-beta 
      (ER-beta) competitive binding assays to reveal the high selective affinity of LA-7 
      towards ER-alpha at 5.49muM, while LA-10 did not show any binding affinity towards 
      neither ER-alpha nor ER-beta; suggesting another mechanism for inhibition. This was 
      validated by in silico molecular docking simulations of LA-7 to reveal the 
      optimum binding affinity of LA-7 towards ER-alpha.
CI  - Copyright (c) 2016. Published by Elsevier Inc.
FAU - Alsayari, Abdulrhman
AU  - Alsayari A
AD  - Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, 
      Saudi Arabia.
FAU - Kopel, Lucas
AU  - Kopel L
AD  - Department of Chemistry and Biochemistry, South Dakota State University, Box 
      2202, Brookings, SD 57007, USA.
FAU - Ahmed, Mahmoud Salama
AU  - Ahmed MS
AD  - Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British 
      University in Egypt, Al-Sherouk City, Cairo, Egypt.
FAU - Pay, Adam
AU  - Pay A
AD  - Department of Chemistry and Biochemistry, South Dakota State University, Box 
      2202, Brookings, SD 57007, USA.
FAU - Carlson, Taylor
AU  - Carlson T
AD  - Department of Chemistry and Biochemistry, South Dakota State University, Box 
      2202, Brookings, SD 57007, USA.
FAU - Halaweish, Fathi T
AU  - Halaweish FT
AD  - Department of Chemistry and Biochemistry, South Dakota State University, Box 
      2202, Brookings, SD 57007, USA. Electronic address: fathi.halaweish@sdstate.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20161120
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 2DI9HA706A (Estrone)
SB  - IM
MH  - Breast Neoplasms/metabolism
MH  - Cell Proliferation/drug effects
MH  - Estrogens/*chemical synthesis/*chemistry/pharmacology
MH  - Estrone/*analogs & derivatives
MH  - Female
MH  - Humans
MH  - MCF-7 Cells
MH  - Magnetic Resonance Spectroscopy
MH  - Receptors, Estrogen/metabolism
OTO - NOTNLM
OT  - Breast cancer
OT  - Breast cancer (MCF-7) cell lines
OT  - Estrogenic/anti-estrogenic activity
OT  - Estrone
EDAT- 2016/11/24 06:00
MHDA- 2017/08/31 06:00
CRDT- 2016/11/24 06:00
PHST- 2016/09/19 00:00 [received]
PHST- 2016/11/13 00:00 [revised]
PHST- 2016/11/17 00:00 [accepted]
PHST- 2016/11/24 06:00 [pubmed]
PHST- 2017/08/31 06:00 [medline]
PHST- 2016/11/24 06:00 [entrez]
AID - S0039-128X(16)30168-4 [pii]
AID - 10.1016/j.steroids.2016.11.005 [doi]
PST - ppublish
SO  - Steroids. 2017 Feb;118:32-40. doi: 10.1016/j.steroids.2016.11.005. Epub 2016 Nov 
      20.